Clinically driven diagnostic antifungal approach in neutropenic patients: A prospective feasibility study

Journal of Clinical Oncology

Volumn 28, Issue 4, 2010, Pages 667-674

  Girmenia, Corrado ^a   Micozzi, Alessandra ^a   Gentile, Giuseppe ^a   Santilli, Stefania ^a   Arleo, Eva ^a   Cardarelli, Luisa ^a   Capria, Saveria ^a   Minotti, Clara ^a   Cartoni, Claudio ^a   Brocchieri, Simonetta ^a   Guerrisi, Vito ^a   Meloni, Giovanna ^a   Foà, Robin ^a   Martino, Pietro ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; CASPOFUNGIN; CIPROFLOXACIN; FLUCONAZOLE; GALACTOMANNAN; ITRACONAZOLE; VORICONAZOLE; ANTIFUNGAL AGENT;

ADULT; AGED; ARTICLE; ASPERGILLOSIS; BLOOD CULTURE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIAGNOSTIC TEST; FEASIBILITY STUDY; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCORMYCOSIS; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; SCREENING TEST; SURVIVAL RATE; THORAX RADIOGRAPHY; ADOLESCENT; ASPERGILLUS; BLOOD DISEASE; CANCER STAGING; MICROBIOLOGY; MIDDLE AGED; NEUTROPENIA; PATHOGENICITY; PROGNOSIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HEMATOLOGIC NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEUTROPENIA; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77449124531     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2009.21.8032     Document Type: Article

References (25)

1. Maschmeyer G, Haas A, Cornely OA. Invasive aspergillosis: Epidemiology, diagnosis and management in immunocompromised patients. Drugs 67: 1567-1601, 2007 (Pubitemid 47267298)
2. Pagano L, Caira M, Candoni A, et al: The epidemiology of fungal infections in patients with hematologic malignancies: The SEIFEM-2004 study. Haematologica 91:1068-1075, 2006
3. Vento S, Cainelli F: Infections in patients with cancer undergoing chemotherapy: Aetiology, prevention, and treatment. Lancet Oncol 4:595-604, 2003 (Pubitemid 37258400)
4. Sipsas NV, Bodey GP, Kontoyiannis DP: Perspectives for the management of febrile neutropenic patients with cancer in the 21st century. Cancer 103:1103-1113, 2005 (Pubitemid 40328079)
5. Segal BH, Almyroudis NG, Battiwalla M, et al: Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. Clin Infect Dis 44:402-409, 2007 (Pubitemid 46147624)
6. Klastersky J, Paesmans M: Antifungal therapy in febrile neutropenic patients: Review of treatment choices and strategies for aspergillar infection. Support Care Cancer 15:137-141, 2007 (Pubitemid 46332929)
7. Wingard JR: New approaches to invasive fungal infections in acute leukemia and hematopoietic stem cell transplant patients. Best Pract Res Clin Haematol 20:99-107, 2007 (Pubitemid 46300057)
8. Hughes WT, Armstrong D, Bodey GP, et al: 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730-751, 2002
9. Corey L, Boeckh M: Persistent fever in patients with neutropenia. N Engl J Med 346:222-224, 2002
10. Mahfouz T, Anaissie E: Prevention of fungal infections in the immunocompromised host. Curr Opin Investig Drugs 4:974-990, 2003 (Pubitemid 37168186)
11. Cherif H, Kalin M, Björkholm M: Antifungal therapy in patients with hematological malignancies: How to avoid overtreatment? Eur J Haematol 77: 288-292, 2006
12. Maertens J, Theunissen K, Verhoef G, et al: Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: A prospective feasibility study. Clin Infect Dis 41:1242-1250, 2005
13. Maertens J, Deeren D, Dierickx D, et al: Preemptive antifungal therapy: Still a way to go. Curr Opin Infect Dis 19:551-556, 2006 (Pubitemid 44665460)
14. Penack O, Rempf P, Graf B, et al: Aspergillus galactomannan testing in patients with long-term neutropenia: Implications for clinical management. Ann Oncol 19:984-989, 2008 (Pubitemid 351627318)
15. Ascioglu S, Rex JH, de Pauw B, et al: Defining opportunistic invasive fungal infections in immuno-compromised patients with cancer and hematopoietic stem cell transplants: An international consensus. Clin Infect Dis 34:7-14, 2002
16. De Pauw B, Walsh TJ, Donnelly JP, et al: Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/ MSG) Consensus Group. Clin Infect Dis 46:1813-1821, 2008
17. Herbrecht R, Denning DW, Patterson TF, et al: Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408-415, 2002 (Pubitemid 34851833)
18. Cornely OA, Maertens J, Bresnik M, et al: Liposomal amphotericin B as initial therapy for invasive mold infection: A randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial). Clin Infect Dis 44:1289-1297, 2007
19. Shaukat A, Bakri F, Young P, et al: Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: Clinical, radiologic, and pathologic characteristics. Mycopathologia 159:181-188, 2005
20. Cornillet A, Camus C, Nimubona S: Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: A 6-year survey. Clin Infect Dis 43:577-584, 2006
21. Greene RE, Schlamm HT, Oestmann JW, et al: Imaging findings in acute invasive pulmonary aspergillosis: Clinical significance of the halo sign. Clin Infect Dis 44:373-379, 2007
22. Weisser M, Rausch C, Droll A, et al: Galactomannan does not precede major signs on a pulmonary computerized tomographic scan suggestive of invasive aspergillosis in patients with hematological malignancies. Clin Infect Dis 41:1143-1149, 2005
23. Marr KA, Balajee SA, McLaughlin L, et al: Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: Variables that affect performance. J Infect Dis 190:641-649, 2004 (Pubitemid 38982107)
24. Walsh TJ, Anaissie EJ, Denning DW, et al: Treatment of aspergillosis: Clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46:327-360, 2008 (Pubitemid 351265310)
25. Cordonnier C, Pautas C, Maury S, et al: Empirical versus preemptive antifungal therapy for highrisk, febrile, neutropenic patients: A randomized, controlled trial. Clin Infect Dis 48:1042-1051, 2009