MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody

Contrast Media and Molecular Imaging

Volumn 5, Issue 1, 2010, Pages 18-22

  Kinoshita, Manabu ^a   Yoshioka, Yoshichika ^b   Okita, Yoshiko ^a   Hashimoto, Naoya ^a   Yoshimine, Toshiki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Affibody; Magnetic resonance imaging (MRI); Molecular imaging; Superparamagnetic iron oxide (SPIO)

Indexed keywords

ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HER 2 TARGETING AFFIBODY; SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR IMAGING; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; FERROSOFERRIC OXIDE; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MICE; MOLECULAR IMAGING; NEOPLASMS; RATS; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; STAINING AND LABELING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77449090882     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.363     Document Type: Article

References (16)

1. 11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clin Cancer Res 2004; 10(21): 7163-7170.
2. Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced highfrequency ultrasonography. J Ultrasound Med 2007; 26(11): 1575-1586.
3. Kato T, Kamei A, Takashima S, Ozaki T. Human visual cortical function during photic stimulation monitoring by means of near-infrared spectroscopy. J Cereb Blood Flow Metab 1993; 13(3): 516-520.
4. Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T. Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors. Neuroimage 2008; 43(1): 29-35.
5. Engel SA. Looking into the black box: new directions in neuroimaging. Neuron 1996; 17(3): 375-378.
6. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med 2005; 11(4): 450-454.
7. Valable S, Barbier EL, Bernaudin M, Roussel S, Segebarth C, Petit E, Remy C. In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma. Neuroimage 2007; 37(suppl 1): S47-58.
8. Zurkiya O, Chan AW, Hu X. MagA is sufficient for producing magnetic nanoparticles in mammalian cells, making it an MRI reporter. Magn Reson Med 2008; 59(6): 1225-1231.
9. Takehara Y, Sakahara H, Masunaga H, Isogai S, Kodaira N, Sugiyama M, Takeda H, Saga T, Nakajima S, Sakata I. Assessment of a potential tumor-seeking manganese metalloporphyrin contrast agent in a mouse model. Magn Reson Med 2002; 47(3): 549-553.
10. McAteer MA, Sibson NR, von Zur Muhlen C, Schneider JE, Lowe AS, Warrick N, Channon KM, Anthony DC, Choudhury RP. In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide. Nat Med 2007; 13(10): 1253-1258.
11. Lee SB, Hassan M, Fisher R, Chertov O, Chernomordik V, Kramer-Marek G, Gandjbakhche A, Capala J. Affibody molecules for in vivo characterization of HER2-positive tumors by near-infrared imaging. Clin Cancer Res 2008; 14(12): 3840-3849.
12. Orlova A, Magnusson M, Eriksson TL, Nilsson M, Larsson B, Hoiden-Guthenberg I, Widstrom C, Carlsson J, Tolmachev V, Stahl S, Nilsson FY. Tumor imaging using a picomolar affinity HER2 binding affibody molecule. Cancer Res 2006; 66(8): 4339-4348.
13. Orlova A, Tolmachev V, Pehrson R, Lindborg M, Tran T, Sandstrom M, Nilsson FY, Wennborg A, Abrahmsen L, Feldwisch J. Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors. Cancer Res 2007; 67(5): 2178-2186.
14. Orlova A, Wallberg H, Stone-Elander S, Tolmachev V. On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft model. J Nucl Med 2009; 50(3): 417-425.
15. Tran T, Engfeldt T, Orlova A, Sandstrom M, Feldwisch J, Abrahmsen L, Wennborg A, Tolmachev V, Karlstrom AE. (99m)Tc-maEEE-Z(HER2: 342), an Affibody molecule-based tracer for the detection of HER2 expression in malignant tumors. Bioconjug Chem 2007; 18(6): 1956-1964.
16. Kinoshita M, Yamada K, Hashimoto N, Kato A, Izumoto S, Baba T, Maruno M, Nishimura T, Yoshimine T. Fiber-tracking does not accurately estimate size of fiber bundle in pathological condition: initial neurosurgical experience using neuronavigation and subcortical white matter stimulation. Neuroimage 2005; 25(2): 424-429.