Preparation and characterization of paclitaxel from plant cell culture

Korean Journal of Chemical Engineering

Volumn 21, Issue 4, 2004, Pages 816-820

  Gi, Un Sook ^a   Min, Bumchan ^a   Lee, Jeong Hoon ^a   Kim, Jin Hyun ^b  

^a Samyang Corporation   (South Korea)

^b Kongju National University   (South Korea)

Author keywords

Amorphous Paclitaxel; Dihydrated Paclitaxel; Physicochemical Property; Spray Drying; Thermo Gravimetric Analysis; X ray Powder Diffraction

Indexed keywords

ACETONITRILE; DIFFERENTIAL SCANNING CALORIMETRY; MORPHOLOGY; PLANT CELL CULTURE; SOLUBILITY; THERMOGRAVIMETRIC ANALYSIS; X RAY POWDER DIFFRACTION;

AMORPHOUS PACLITAXEL; SPRAY DRYING; VACUUM OVENS;

DRUG PRODUCTS;

EID: 7744239557     PISSN: 02561115     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02705526     Document Type: Article

References (16)

1. Angell, C. A., Monnerie, L. and Torell, L. M., "Strong and Fragile Behavior in Liquid Polymers," Mat. Res. Soc. Sym. Proc., 215, 3 (1991).
2. Chiou, W. L. and Riegelman, S., "Pharmaceutical Applications of Solid Dispersion Systems," J. Pharm. Sci., 60, 1281 (1971).
3. Choi, H. K., Yun, J. H., Kim, S. I., Son, J. S., Kim, H. R., Kim, J. H., Choi, H. J. and Hong, S.S., "Enhanced Production of Paclitaxel by Semi-Continuous Batch Process (SCBP) in Suspension Culture of Taxus chinensis," Enzyme Microb. Technol., 29, 583 (2001).
4. Gi, U. S., Min, B., Hong, S. S., Lee, H. S. and Kim, J. H., "Isolation and Identification of Non-Polar Taxane Derivatives from the Plant Cell Culture of Taxus chinensis," Agri. Chem. Biotech., 43, 176 (2000).
5. Hancock, B. C., Shamblin, S. L. and Zografi, G., "Molecular Mobility of Amorphous Pharmaceutical Solids below Their Glass Transition Temperatures," Pharm. Res., 12, 799 (1995).
6. ICH guidance Q3C impurities: Residual Solvents, Federal register, 62(247), 67378 (1997).
7. Kim, J. H. and Hong, S. S., "Optimization of Extraction Process for Mass Production of Paclitaxel from Plant Cell Cultures," Korean J. Biotechnol. Bioeng., 15, 346 (2000).
8. Kim, J. H., Choi, H. K., Hong, S. S. and Lee, H. S., "Development of High Performance Liquid Chromatography for Paclitaxel Purification from Plant Cell Cultures," J. Microbiol. Biotechnol., 11, 204 (2002).
9. Kim, J. H., Kang, I. S., Choi, H. K., Hong, S. S. and Lee, H. S., "A Novel Prepurification for Paclitaxel from Plant Cell Cultures," Process Biochem., 37, 679 (2002).
10. Kwon, I. C., Yoo, Y. J., Lee, J. H. and Hyun, J. O., "Enhancement of Taxol Production by in situ Recovery of Product," Process Biochem., 33, 701 (1998).
11. Liggins, R. T., Hunter, W. L. and Burt, H. M., "Solid-State Characterization of Paclitaxel," J. Pharm. Sci., 86, 1458 (1997).
12. Martin, A., Swarbrick, J. and Cammarata, A., "Physical Pharmacy," Lea and Febiger, Philadelphia (1983).
13. Mathew, A. E., Mejillano, M. R., Nath, J. P., Himes, R. H. and Stella, V. J., "Synthesis and Evaluation of Some Water-Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity," J. Med. Chem., 35, 145 (1992).
14. Nicolaou, K. C., Yang, Z., Liu, J. J., Ueno, H., Nantermet, P. G., Guy, R. K., Claiborne, C. F., Renaud, J., Couladouros, E. A., Paulvannan, K. and Sorensen, E. J., "Total Synthesis of Taxol," Nature, 367, 640 (1994).
15. Sharma, U. S., Baulausbramanaian, S. V. and Straubinger, R. M., "Pharmaceutical and Physical Properties of Paclitaxel Complexes with Cyclodextrins," J. Pharm. Sci., 84, 1223 (1995).
16. Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P. and Mcphail, A. T., "Plant Antitumor Agents, VI. The Isolation and the Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus brevifolia," J. Am. Chem. Soc., 93, 2325 (1971).