Development of high performance liquid chromatography for paclitaxel purification from plant cell cultures

Journal of Microbiology and Biotechnology

Volumn 11, Issue 2, 2001, Pages 204-210

  Kim, Jin Hyun ^a   Choi, Hyung Kyoon ^a   Hong, Seung Suh ^a   Lee, Hyun Soo ^a  

^a Samyang Corporation   (South Korea)

Author keywords

High performance liquid chromatography; Paclitaxel; Plant cell culture; Purification; Taxus chinensis

Indexed keywords

PACLITAXEL; SOLVENT; TAXOID;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CONTROLLED STUDY; COST; DEVELOPMENT; DRUG IMPURITY; DRUG MANUFACTURE; DRUG PURIFICATION; ENVIRONMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; NONHUMAN; PLANT; PLANT CELL; REVERSED PHASE LIQUID CHROMATOGRAPHY; STAGING; TAXUS CHINENSIS;

TAXUS CHINENSIS;

EID: 6644225244     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Cardellina II, J. H. 1991. HPLC separation of taxol and cephalomannine. J Liq. Chromatogr. 14: 659-665.
2. Carver, D. R., T. R. Prout, C. T. Workman, and C. L. Hughes. 1996. Reverse osmosis and ultrafiltration methods for solutions to isolate desired solutes including Taxane. U.S. Patent 5,549,830.
3. Castor, T. P. and T. A. Tyler. 1993. Determination of taxol in taxus media needles in the presence of interfering compounds. J Liq. Chromatogr. 16: 723-731.
4. Castor, T. P. 1998. Method and apparatus for isolating therapeutic compositions from source materials. U.S. Patent 5,750,709.
5. Choi, H. K., T. L. Adams, R. W. Stahlhut, S. I. Kim, J. H. Yun, B. K. Song, J. H. Kim, S. S. Hong, and H. S. Lee. 1999. Method for mass production of taxol by semi-continuous culture with Taxus chinensis cell culture. U.S. Patent, 5,871,979.
6. Choi, Y. S., S. Y. Lee, and D. I. Kim. 1999. Cultivation of Digitalis lanata cell suspension in an aqueous two-phase system. J. Microbiol. Biotechnol. 9: 589-592.
7. ElSohly, H. N., E. M. Jr. Croom, M. A. ElSohly, and J. D. McChesney. 1997. Methods and compositions for isolating taxanes. U.S. Patent 5,618,538.
8. Hong, S. S., B. K. Song, J. H. Kim, C. B. Lim, H. S. Lee, K. W. Kim, I. S. Kang, and H. B. Park. 1999. Method for purifying taxol from Taxus biomass. U.S. Patent, 5,900,979.
9. Ma, W., G. L. Park, G. A. Gomez, M. H. Nieder, T. L. Adams, J. S. Aynsley, O. P. Sahai, R. J. Smith, R. W. Stahlhut, and P. J. Hylands. 1994. New bioactive taxoids from cell cultures of Taxus baccata. J. Nat. Prod. 57: 116-122.
10. Nair, M. G. 1995. Process for the isolation and purification of taxol and taxanes from Taxus using methanol or acetone. U.S. Patent 5,478,736.
11. Rao, K. V. 1997. Method for the isolation and purification of taxol and its natural analogues. U.S. Patent 5,670,673.
12. Rao, K. V., J. B. Hanuman, C. Alvarez, M. Stoy, J. Juchum, R. M. Davies, and R. Baxley. 1995. A new large-scale process for taxol and related taxanes from Taxus brevifolia. Pharm. Res. 12: 1003-1010.
13. Sohn, H. and M. R. Okos. 1998. Paclitaxel (Taxol): From nutt to drug. J. Microbiol. Biotechnol. 8: 427-440.
14. Stull, D. P., T. A. Scales, R. Daughenbaugh, N. A. Jans, and D. T. Bailey. 1995. Taxol (Paclitaxel), strategies to increase the supply of a new anticancer drug. Appl. Biochem. Biotechnol. 54: 133-140.
15. Vanhaelen-Fastre, R., B. Diallo, M. Jaziri, M. L. Faes, J, Homes, and M. Vanhaelen. 1992. High-speed countercurrent chromatography separation of taxol and related diterpenoids from Taxus baccata. J. Liq. Chromatogr. 15: 697-706.
16. Witherup, K. M., S. A. Look, M. W. Stasko, T. J. Ghiorzi, and G. M. Muschik. 1990. Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: Analysis and isolation. J. Nat. Prod. 53: 1249-1255.
17. Wu, D. J., Z. Ma, and N.-H. L. Wang. 1999. Optimization of throughput and desorbent in SMB chromatography for paclitaxel purification. J. Chromatogr. A 855: 71-89.
18. Zhang, Z. and Z. Jia. 1991. Taxanes from Taxus chinensis. Phytochem. 30: 2345-2348.