Testosterone selectively affects aromatase and 5α-reductase activities in the green anole lizard brain

General and Comparative Endocrinology

Volumn 166, Issue 1, 2010, Pages 128-133

  Cohen, Rachel E ^a   Wade, Juli ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Seasonal difference; Sexual dimorphism; Steroid hormone; Steroid metabolism

Indexed keywords

AROMATASE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ARTICLE; BREEDING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; LIZARD; MALE; NONHUMAN; PRIORITY JOURNAL; SEXUAL BEHAVIOR; UPREGULATION;

EID: 77349127307     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2009.11.006     Document Type: Article

References (46)

1. Bakker J., Honda S., Harada N., Bathazart J. Restoration of male sexual behavior by adult exogenous estrogens in male aromatase knockout mice. Horm. Behav. 2004, 46:1-10.
2. Balthazart J., Foidart A. Brain aromatase and the control of male sexual behavior. J. Steroid Biochem. Mol. Biol. 1993, 44(4-6):521-540.
3. Balthazart J., Schumacher M., Evrard L. Sex differences and steroid control of testosterone-metabolizing enzyme activity in the quail brain. J. Neuroendocrinol. 1990, 2(5):675-683.
4. Balthazart J., Foidart A., Houbart M., Prins G.S., Ball G.F. Distribution of androgen receptor-immunoreactive cells in the quail forebrain and their relationship with aromatase-immunoreactivity. J. Neurobiol. 1998, 35:323-340.
5. Balthazart J. Testosterone metabolism in the avian hypothalamus. J. Steroid Biochem. Mol. Biol. 1991, 40:557-570.
6. Baum M.J., Vreeburg J.T. Copulation in castrated male rats following combined treatment with estradiol and dihydrotestosterone. Science 1973, 182:283-285.
7. Canoine V., Fusiani L., Schlinger B., Hau M. Low sex steroids, high steroid receptors: increasing the sensitivity of the nonreproductive brain. J. Neurobiol. 2007, 67:57-67.
8. Celotti F., Negri-Cesi P., Poletti A. Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization. Brain Res. Bull. 1997, 44(4):365-375.
9. Crews D. Interrelationships among ecological, behavioral, and neuroendocrine processes in the reproductive cycle of Anolis carolinensis and other reptiles. Advances in the Study of Behavior 1980, vol. 2:1-73. Academic Press, New York.
10. Fadem B.H., Walters M., MacLusky N.J. Neural aromatase activity in a marsupial, the gray short-tailed opossum (Monodelphis domestica): ontogeny during postnatal development and androgen regulation in adulthood. Dev. Brain Res. 1993, 74:199-205.
11. Forlano P.M., Bass A.H. Steroid regulation of brain aromatase expression in glia: female preoptic and vocal motor nuclei. J. Neurobiol. 2005, 65:50-58.
12. Forlano P.M., Schlinger B.A., Bass A.H. Brain aromatase: new lessons from non-mammalian model systems. Front. Neuroendocrinol. 2006, 27:247-274.
13. Fusani L., Hutchison J.B., Gahr M. Testosterone regulated the activity and expression of aromatase in the canary neostriatum. J. Neurobiol. 2001, 49:1-8.
14. Garcia-Segura L.M. Aromatase in the brain: not just for reproduction anymore. J. Neuroendocrinol. 2008, 20:705-712.
15. Gelinas D., Callard D.V. Immunolocalization of aromatase and androgen-positive neurons in the goldfish brain. Gen. Comp. Endocrinol. 1997, 106:155-168.
16. Holmes M.M., Wade J. Seasonal plasticity in the copulatory neuromuscular system of green anole lizards: a role for testosterone in muscle but not motoneuron morphology. J. Neurobiol. 2004, 60:1-11.
17. Holmes M.M., Wade J. Testosterone regulates androgen receptor in the copulatory, but not courtship, neuromuscular system in adult male green anoles. J. Neuroendocrinol. 2005, 17:560-569.
18. Lephart E.D., Lund T.D., Horvath T.L. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Res. Rev. 2001, 37:25-37.
19. Lovern M.B., Wade J. Maternal plasma and egg yolk testosterone concentrations during embryonic development in green anoles (Anolis carolinensis). Gen. Comp. Endocrinol. 2001, 124:226-235.
20. Lovern M.B., McNabb F.M.A., Jenssen T.A. Developmental effects of testosterone on behavior in male and female green anoles (Anolis carolinensis). Horm. Behav. 2001, 39:131-143.
21. Mason P., Adkins E.K. Hormones and social behavior in the lizard, Anolis carolinensis. Horm. Behav. 1976, 7:75-86.
22. McNicol D., Crews D. Estrogen/progesterone energy in the control of female sexual receptivity in the lizard, Anolis carolinensis. Gen. Comp. Endocrinol. 1979, 38:68-74.
23. Neal J.K., Wade J. Courtship and copulation in the adult male green anole: effects of season, hormone and female contact on reproductive behavior and morphology. Behav. Brain Res. 2007, 177:177-185.
24. Negri-Cesi P., Poletti A., Celotti F. Metabolism of steroids in the brain: a new insight into the role of 5α-reductase and aromatase in brain differentiation and functions. Steroid Biochem. Mol. Biol. 1996, 58(5/6):455-466.
25. Negri-Cesi P., Colciago A., Pravettoni A., Casati L., Conti L., Celotti F. Sexual differentiation of the rodent hypothalamus: hormonal and environmental influences. J. Steroid Biochem. Mol. Biol. 2008, 109:294-299.
26. Orrell K.S., Jenssen T.A. Heterosexual signaling by the lizard Anolis carolinensis, with intersexual comparisons across contexts. Behaviour 2003, 140:603-634.
27. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 1992, 6:2311-2322.
28. Rissman E.F. Evidence that neuronal aromatization of androgen regulates the expression of sexual behavior in female musk shrews. J. Neuroendocrinol. 1991, 3(4):441-448.
29. Romeo R.D., Wade J., Venier J.E., Sisk C.L. Androgenic regulation of hypothalamic aromatase activity in prepubertal and postpubertal male golden hamsters. Endocrinology 1999, 140(1):112-117.
30. Romeo R.D., Cook-Weins E., Richardson H.N., Sisk C.L. Dihydrotestosterone activates sexual behavior in adult male hamsters but not in juveniles. Physiol. Behav. 2001, 73:579-584.
31. Roselli C.E., Resko J.A. Androgens regulate brain aromatase activity in adult male rats through a receptor mechanism. Endocrinology 1984, 114:2183-2189.
32. Roselli C.E., Resko J.A. Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain. J. Steroid Biochem. Mol. Biol. 1997, 61(3-6):365-374.
33. Roselli C.E., Klosterman S.A., Fasasi T.A. Sex differences in androgen responsiveness in the rat brain: regional differences in the induction of aromatase activity. Neuroendocrinology 1996, 64:139-145.
34. Roselli C.F. Brain aromatase: roles in reproduction and neuroprotection. J. Steroid Biochem. Mol. Biol. 2007, 106:143-150.
35. Rosen G.J., Wade J. The role of 5α-reductase activity in sexual behaviors of the green anole lizard. Physiol. Behav. 2000, 69:487-498.
36. Rosen G.J., Wade J. Androgen metabolism in the brain of the green anole lizard (Anolis carolinensis): effects of sex and season. Gen. Comp. Endocrinol. 2001, 122:40-47.
37. Sawilowsky S.S. Nonparametric tests of interaction in experimental design. Rev. Educ. Res. 1990, 60(1):91-126.
38. Schlinger B.A. The activity and expression of aromatase in songbirds. Brain Res. Bull. 1997, 44(4):359-364.
39. Schlinger B.A. Sex steroids and their actions on the birdsong system. J. Neurobiol. 1997, 33:619-631.
40. Soma K.K., Schlinger B.A., Wingfield J.C., Saldanha C.J. Brain aromatase, 5-reductase, and 5-reductase change seasonally in wild male song sparrows: relationship to aggressive and sexual behavior. J. Neurobiol. 2003, 56:209-221.
41. Timonin M.E., Wynne-Edwards K.E. Aromatase inhibition during adolescence reduces adult sexual and paternal behavior in the biparental dwarf hamster Phodopus campbelli. Horm. Behav. 2008, 54:748-757.
42. Torres J.M., Ortega E. Differential regulation of steroid 5α-reductase isozymes expression by androgens in the adult rat brain. FASEB J. 2003, 17:1428-1433.
43. Torres J.M., Ortega E. Steroid 5α-reductase in the adult female rat brain: central role of dihydrotestosterone. J. Mol. Endocrinol. 2006, 36:239-245.
44. Veney S.L., Rissman E.F. Immunolocalization of androgen receptors and aromatase enzyme in the adult musk shrew. Neuroendocrinology 2000, 72:29-36.
45. Wade J. Androgen metabolism in the brain of the green anole lizard (Anolis carolinensis). Gen. Comp. Endocrinol. 1997, 106:127-137.
46. Winkler S.M., Wade J. Aromatase activity and regulation of sexual behaviors in the green anole lizard. Physiol. Behav. 1998, 64(5):723-731.