Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats

Journal of the International Society of Sports Nutrition

Volumn 7, Issue , 2010, Pages

  Roschel, Hamilton ^a   Gualano, Bruno ^a   Marquezi, Marcelo ^a   Costa, André ^a   Lancha Jr, Antonio H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 77349084203     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-7-6     Document Type: Article

References (34)

1. Gualano B, Novaes RB, Artioli GG, Freire TO, Coelho DF, Scagliusi FB, Rogeri PS, Roschel H, Ugrinowitsch C, Lancha AH. Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training. Amino Acids 2008, 34:245-250. 10.1007/s00726-007-0508-1, 17396216.
2. Greenhaff PL. The creatine-phosphocreatine system: there's more than one song in its repertoire. J Physiol 2001, 537:657. 10.1113/jphysiol.2001.013478, 2278982, 11744744.
3. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond) 1992, 83:367-374.
4. Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJ, Williams MH. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000, 32:706-717. 10.1097/00005768-200003000-00024, 10731017.
5. Robinson TM, Sewell DA, Hultman E, Greenhaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J Appl Physiol 1999, 87:598-604.
6. Nelson AG, Arnall DA, Kokkonen J, Day R, Evans J. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc 2001, 33:1096-1100.
7. Derave W, Eijnde BO, Verbessem P, Ramaekers M, Van Leemputte M, Richter EA, Hespel P. Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans. J Appl Physiol 2003, 94:1910-1916.
8. van Loon LJ, Murphy R, Oosterlaar AM, Cameron-Smith D, Hargreaves M, Wagenmakers AJ, Snow R. Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci (Lond) 2004, 106:99-106. 10.1042/CS20030116, 14507259.
9. Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertrophy. Med Sci Sports Exerc 2006, 38:1918-1925. 10.1249/01.mss.0000233790.08788.3e, 17095924.
10. Tsintzas K, Williams C, Constantin-Teodosiu D, Hultman E, Boobis L, Clarys P, Greenhaff P. Phosphocreatine degradation in type I and type II muscle fibres during submaximal exercise in man: effect of carbohydrate ingestion. J Physiol 2001, 537:305-311. 10.1111/j.1469-7793.2001.0305k.x, 2278942, 11711582.
11. Sewell DA, Robinson TM, Greenhaff PL. Creatine supplementation does not affect human skeletal muscle glycogen content in the absence of prior exercise. J Appl Physiol 2008, 104:508-512. 10.1152/japplphysiol.00787.2007, 18032580.
12. Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK. Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise. J Appl Physiol 1996, 80:876-884.
13. Gaitanos GC, Williams C, Boobis LH, Brooks S. Human muscle metabolism during intermittent maximal exercise. J Appl Physiol 1993, 75:712-719.
14. Hargreaves M, McKenna MJ, Jenkins DG, Warmington SA, Li JL, Snow RJ, Febbraio MA. Muscle metabolites and performance during high-intensity, intermittent exercise. J Appl Physiol 1998, 84:1687-1691.
15. Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation. Amino Acids 2009,
16. Marquezi ML, Roschel HA, dos Santa Costa A, Sawada LA, Lancha AH. Effect of aspartate and asparagine supplementation on fatigue determinants in intense exercise. Int J Sport Nutr Exerc Metab 2003, 13:65-75.
17. Gallo M, Gordon T, Syrotuik D, Shu Y, Tyreman N, MacLean I, Kenwell Z, Putman CT. Effects of long-term creatine feeding and running on isometric functional measures and myosin heavy chain content of rat skeletal muscles. Pflugers Arch 2006, 452:744-755. 10.1007/s00424-006-0079-0, 16688465.
18. Op't Eijnde B, Jijakli H, Hespel P, Malaisse WJ. Creatine supplementation increases soleus muscle creatine content and lowers the insulinogenic index in an animal model of inherited type 2 diabetes. Int J Mol Med 2006, 17:1077-1084.
19. Passonneau JV, Lowry OH. Enzymatic Analysis: A Practical Guide 1993, New Jersey: Human Press.
20. Ugrinowitsch C, Fellingham GW, Ricard MD. Limitations of Ordinary Least Squares Models in Analyzing Repeated Measures Data. Med Sci Sports Exerc 2004, 36:2144-2148. 10.1249/01.MSS.0000147580.40591.75, 15570152.
21. Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 1994, 266:E725-730.
22. Op 't Eijnde B, Richter EA, Henquin JC, Kiens B, Hespel P. Effect of creatine supplementation on creatine and glycogen content in rat skeletal muscle. Acta Physiol Scand 2001, 171:169-176. 10.1046/j.1365-201x.2001.00786.x, 11350277.
23. Brannon TA, Adams GR, Conniff CL, Baldwin KM. Effects of creatine loading and training on running performance and biochemical properties of rat skeletal muscle. Med Sci Sports Exerc 1997, 29:489-495.
24. Yquel RJ, Arsac LM, Thiaudiere E, Canioni P, Manier G. Effect of creatine supplementation on phosphocreatine resynthesis, inorganic phosphate accumulation and pH during intermittent maximal exercise. J Sports Sci 2002, 20:427-437. 10.1080/026404102317366681, 12043832.
25. Ceddia RB, Sweeney G. Creatine supplementation increases glucose oxidation and AMPK phosphorylation and reduces lactate production in L6 rat skeletal muscle cells. J Physiol 2004, 555:409-421. 10.1113/jphysiol.2003.056291, 1664837, 14724211.
26. Sewell DA, Harris RC. Effect of creatine supplementation in the thoroughbred horse. Equine Vet J 1995, 18:239-242.
27. Tarnopolsky MA, Bourgeois JM, Snow R, Keys S, Roy BD, Kwiecien JM, Turnbull J. Histological assessment of intermediate- and long-term creatine monohydrate supplementation in mice and rats. Am J Physiol Regul Integr Comp Physiol 2003, 285:R762-769.
28. Pederson BA, Cope CR, Schroeder JM, Smith MW, Irimia JM, Thurberg BL, DePaoli-Roach AA, Roach PJ. Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise. J Biol Chem 2005, 280:17260-17265. 10.1074/jbc.M410448200, 15711014.
29. Freire TO, Gualano B, Leme MD, Polacow VO, Lancha Junior AH. Effects of creatine supplementation on glucose uptake in rats submitted to exercise training. Braz J Sports Med 2008, 14:431-435.
30. Armstrong RB, Saubert C, Sembrowich WL, Shepherd RE, Gollnick PD. Glycogen depletion in rat skeletal muscle fibers at different intensities and durations of exercise. Pflugers Arch 1974, 352:243-256. 10.1007/BF00590489, 4475410.
31. Clark JH, Conlee RK. Muscle and liver glycogen content: diurnal variation and endurance. J Appl Physiol 1979, 47:425-428.
32. Conlee RK, Rennie MJ, Winder WW. Skeletal muscle glycogen content: diurnal variation and effects of fasting. Am J Physiol 1976, 231:614-618.
33. Conlee RK, McLane JA, Rennie MJ, Winder WW, Holloszy JO. Reversal of phosphorylase activation in muscle despite continued contractile activity. Am J Physiol 1979, 237:R291-296.
34. Hickson RC, Rennie MJ, Conlee RK, Winder WW, Holloszy JO. Effects of increased plasma fatty acids on glycogen utilization and endurance. J Appl Physiol 1977, 43:829-833.