메뉴 건너뛰기




Volumn 23, Issue 3, 2010, Pages 639-645

Overexpression of EGFR pathway-related genes in the circulation is highly correlated with EGFR mutations and overexpression in paired cancer tissue from patients with non-small cell lung cancer

Author keywords

Epidermal growth factor receptor; Non small cell lung cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 77349083210     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000679     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 1842471336 scopus 로고    scopus 로고
    • Signaling through the epidermal growth factor receptor during the development of malignancy
    • Grandis JR and Sok JC: Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther 102: 37-46, 2004.
    • (2004) Pharmacol Ther , vol.102 , pp. 37-46
    • Grandis, J.R.1    Sok, J.C.2
  • 2
    • 0025093825 scopus 로고
    • Developmental activities of the epidermal growth factor receptor
    • Adamson ED: Developmental activities of the epidermal growth factor receptor. Curr Top Dev Biol 24: 1-29, 1990.
    • (1990) Curr Top Dev Biol , vol.24 , pp. 1-29
    • Adamson, E.D.1
  • 3
    • 34548404210 scopus 로고    scopus 로고
    • Mechanisms for oncogenic activation of the epidermal growth factor receptor
    • Zandi R, Larsen AB, Andersen P, Stockhausen MT and Poulsen HS: Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal 19: 2013-2023, 2007.
    • (2007) Cell Signal , vol.19 , pp. 2013-2023
    • Zandi, R.1    Larsen, A.B.2    Andersen, P.3    Stockhausen, M.T.4    Poulsen, H.S.5
  • 5
    • 34247882824 scopus 로고    scopus 로고
    • Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory nonsmall cell lung cancer (NSCLC)
    • Gadgeel SM, Ruckdeschel JC, Heath EI, Heilbrun LK, Venkatramanamoorthy R and Wozniak A: Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory nonsmall cell lung cancer (NSCLC). J Thorac Oncol 2: 299-305, 2007.
    • (2007) J Thorac Oncol , vol.2 , pp. 299-305
    • Gadgeel, S.M.1    Ruckdeschel, J.C.2    Heath, E.I.3    Heilbrun, L.K.4    Venkatramanamoorthy, R.5    Wozniak, A.6
  • 6
    • 43549105662 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) targeted therapies in non-small cell lung cancer (NSCLC)
    • Metro G, Finocchiaro G, Toschi L, et al: Epidermal growth factor receptor (EGFR) targeted therapies in non-small cell lung cancer (NSCLC). Rev Recent Clin Trials 1: 1-13, 2006.
    • (2006) Rev Recent Clin Trials , vol.1 , pp. 1-13
    • Metro, G.1    Finocchiaro, G.2    Toschi, L.3
  • 7
    • 1542503756 scopus 로고    scopus 로고
    • Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: How do we go from INTACT to impact?
    • Baselga J: Combining the anti-EGFR agent gefitinib with chemotherapy in non-small-cell lung cancer: how do we go from INTACT to impact? J Clin Oncol 22: 759-761, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 759-761
    • Baselga, J.1
  • 8
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
    • Matar P, Rojo F, Cassia R, et al: Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res 10: 6487-6501, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3
  • 9
    • 34547410311 scopus 로고    scopus 로고
    • Cellular responses to EGFR inhibitors and their relevance to cancer therapy
    • Dutta PR and Maity A: Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer Lett 254: 165-177, 2007.
    • (2007) Cancer Lett , vol.254 , pp. 165-177
    • Dutta, P.R.1    Maity, A.2
  • 10
    • 33744832399 scopus 로고    scopus 로고
    • Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer
    • Dziadziuszko R, Witta SE, Cappuzzo F, et al: Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res 12: 3078-3084, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 3078-3084
    • Dziadziuszko, R.1    Witta, S.E.2    Cappuzzo, F.3
  • 11
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch FR, Varella-Garcia M, McCoy J, et al: Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 23: 6838-6845, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3
  • 12
    • 24344441905 scopus 로고    scopus 로고
    • Detection of circulating cancer cells with K-ras oncogene using membrane array
    • Chen YF, Wang JY, Wu CH, Chen FM, Cheng TL and Lin SR: Detection of circulating cancer cells with K-ras oncogene using membrane array. Cancer Lett 229: 115-122, 2005.
    • (2005) Cancer Lett , vol.229 , pp. 115-122
    • Chen, Y.F.1    Wang, J.Y.2    Wu, C.H.3    Chen, F.M.4    Cheng, T.L.5    Lin, S.R.6
  • 13
    • 34548008404 scopus 로고    scopus 로고
    • Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing
    • Chong IW, Chang MY, Sheu CC, et al: Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing. Oncol Rep 18: 17-24, 2007.
    • (2007) Oncol Rep , vol.18 , pp. 17-24
    • Chong, I.W.1    Chang, M.Y.2    Sheu, C.C.3
  • 14
    • 33750109222 scopus 로고    scopus 로고
    • Different responses to gefitinib in lung adenocarcinoma coexpressing mutant- and wild-type epidermal growth factor receptor genes
    • Chou WC, Huang SF, Yeh KY, et al: Different responses to gefitinib in lung adenocarcinoma coexpressing mutant- and wild-type epidermal growth factor receptor genes. Jpn J Clin Oncol 36: 523-526, 2006.
    • (2006) Jpn J Clin Oncol , vol.36 , pp. 523-526
    • Chou, W.C.1    Huang, S.F.2    Yeh, K.Y.3
  • 15
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J and Haber DA: Epidermal growth factor receptor mutations in lung cancer. Nat Rev 7: 169-181, 2007.
    • (2007) Nat Rev , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 16
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinibsensitizing EGFR mutations in lung cancer activate antiapoptotic pathways
    • Sordella R, Bell DW, Haber DA and Settleman J: Gefitinibsensitizing EGFR mutations in lung cancer activate antiapoptotic pathways. Science 305: 1163-1167, 2004.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 17
    • 27144454933 scopus 로고    scopus 로고
    • Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII
    • Pedersen MW, Pedersen N, Ottesen LH and Poulsen HS: Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer 93: 915-923, 2005.
    • (2005) Br J Cancer , vol.93 , pp. 915-923
    • Pedersen, M.W.1    Pedersen, N.2    Ottesen, L.H.3    Poulsen, H.S.4
  • 18
    • 0034758726 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors - ZD1839 (Iressa)
    • Arteaga CL and Johnson DH: Tyrosine kinase inhibitors - ZD1839 (Iressa). Curr Opin Oncol 13: 491-498, 2001.
    • (2001) Curr Opin Oncol , vol.13 , pp. 491-498
    • Arteaga, C.L.1    Johnson, D.H.2
  • 19
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) (corrected)
    • Fukuoka M, Yano S, Giaccone G, et al: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) (corrected). J Clin Oncol 21: 2237-2246, 2003.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 20
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290: 2149-2158, 2003.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 21
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350: 2129-2139, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 22
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497-1500, 2004.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 23
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101: 13306-13311, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 24
    • 4444332925 scopus 로고    scopus 로고
    • Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
    • Cappuzzo F, Magrini E, Ceresoli GL, et al: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 96: 1133-1141, 2004.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1133-1141
    • Cappuzzo, F.1    Magrini, E.2    Ceresoli, G.L.3
  • 25
    • 19944426858 scopus 로고    scopus 로고
    • High frequency of epidermal growth factor receptor mutations with complex patterns in nonsmall cell lung cancers related to gefitinib responsiveness in Taiwan
    • Huang SF, Liu HP, Li LH, et al: High frequency of epidermal growth factor receptor mutations with complex patterns in nonsmall cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res 10: 8195-8203, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 8195-8203
    • Huang, S.F.1    Liu, H.P.2    Li, L.H.3
  • 26
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
    • Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T and Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 64: 8919-8923, 2004.
    • (2004) Cancer Res , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6
  • 27
    • 33750381018 scopus 로고    scopus 로고
    • Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L
    • Asahina H, Yamazaki K, Kinoshita I, Yokouchi H, Dosaka-Akita H and Nishimura M: Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. Lung Cancer 54: 419-422, 2006.
    • (2006) Lung Cancer , vol.54 , pp. 419-422
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3    Yokouchi, H.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 28
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • Kosaka T, Yatabe Y, Endoh H, et al: Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 12: 5764-5769, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3
  • 29
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97: 339-346, 2005.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 30
    • 26644465742 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression status in lung cancer correlates with its mutation
    • Suzuki M, Shigematsu H, Hiroshima K, et al: Epidermal growth factor receptor expression status in lung cancer correlates with its mutation. Hum Pathol 36: 1127-1134, 2005.
    • (2005) Hum Pathol , vol.36 , pp. 1127-1134
    • Suzuki, M.1    Shigematsu, H.2    Hiroshima, K.3
  • 31
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in nonsmall-cell lung cancer patients treated with gefitinib
    • Han SW, Kim TY, Hwang PG, et al: Predictive and prognostic impact of epidermal growth factor receptor mutation in nonsmall-cell lung cancer patients treated with gefitinib. J Clin Oncol 23: 2493-2501, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3
  • 32
    • 33750962024 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib in a phase III placebocontrolled study in advanced non-small-cell lung cancer
    • Hirsch FR, Varella-Garcia M, Bunn PA Jr, et al: Molecular predictors of outcome with gefitinib in a phase III placebocontrolled study in advanced non-small-cell lung cancer. J Clin Oncol 24: 5034-5042, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 5034-5042
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr, P.A.3
  • 33
    • 34250161814 scopus 로고    scopus 로고
    • Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL Trial
    • Cappuzzo F, Ligorio C, Janne PA, et al: Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL Trial. J Clin Oncol 25: 2248-2255, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 2248-2255
    • Cappuzzo, F.1    Ligorio, C.2    Janne, P.A.3
  • 34
    • 85184385018 scopus 로고    scopus 로고
    • Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer
    • In press
    • Hosokawa S, Toyooka S, Fujiwara Y, et al: Comprehensive analysis of EGFR signaling pathways in Japanese patients with non-small cell lung cancer. Lung Cancer (In press).
    • Lung Cancer
    • Hosokawa, S.1    Toyooka, S.2    Fujiwara, Y.3
  • 35
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-smallcell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E, et al: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-smallcell lung cancer. J Natl Cancer Inst 97: 643-655, 2005.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.