Suppression of alcohol dependence using high-dose baclofen: An observational study;Suppression de la dépendance à l'alcool et de la consommation d'alcool par le baclofène à haute dose : un essai en ouvert

Annales Medico-Psychologiques

Volumn 168, Issue 2, 2010, Pages 159-162

  Ameisen, O ^a   de Beaurepaire, R ^b  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b Centre Hospitalier Paul Guiraud   (France)

Author keywords

Alcohol dependence; Alcoholism; Baclofen; Motivation to drink

Indexed keywords

BACLOFEN;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; BEHAVIOR CHANGE; CLINICAL TRIAL; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG DOSE ESCALATION; DRUG MEGADOSE; HUMAN; MOTIVATION; OBSERVATIONAL STUDY;

EID: 77249160641     PISSN: 00034487     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amp.2009.12.008     Document Type: Article

References (20)

1. Addolorato G., Caputo F., Capristo E., Colombo G., Gessa G.L., and Gasbarrini G. Ability of baclofen in reducing alcohol craving and intake: II-preliminary clinical evidence. Alcohol Clin Exp Res 24 (2000) 67-71
2. Addolorato G., Leggio L., Ferrulli A., Cardone S., Vonghia L., Mirijello A., et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: Randomised, double-blind controlled study. Lancet 370 (2007) 1915-1922
3. Agabio R., Marras P., Addolorato G., Carpiniello B., and Gessa G.L. Baclofen suppresses alcohol intake and craving for alcohol in a schizophrenic alcohol-dependent patient: A case report. J Clin Psychopharmacol 27 (2007) 319-320
4. Ameisen O. Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: A self case-report of a physician. Alcohol Alcohol 40 (2005) 147-150
5. Ameisen O. Naltrexone treatment for alcohol dependency. JAMA 294 (2005) 899-900
6. Ameisen O. Le dernier verre (2008), Denoël, Paris
7. Bankole A., and Johnson B.A. Update on neuropharmacological treatments for alcoholism: Scientific basis and clinical findings. Biochem Pharmacol 75 (2008) 34-56
8. Bucknam W. Suppression of symptoms of alcohol dependence and craving using high-dose baclofen. Alcohol Alcohol 42 (2007) 158-160
9. Colombo G., Vacca G., Serra S., Brunetti G., Carai M.A., and Gessa G.L. Baclofen suppresses motivation to consume alcohol in rats. Psychopharmacology (Berl) 167 (2003) 221-224
10. Flannery B.A., Garbutt J.C., Cody M.W., Renn W., Grace K., Osborne M., et al. Baclofen for alcohol dependence: A preliminary open-label study. Alcohol Clin Exp Res 28 (2004) 1517-1523
11. Heinz A., Beck A., Grüsser S.M., Grace A.A., and Wrase J. Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14 (2009) 108-118
12. Greene P. Baclofen in the treatment of dystonia. Clin Neuropharmacol 15 (1992) 276-288
13. Krupitsky E.M., Burakov A.M., Ivanov V.B., Krandashova G.F., Lapin I.P., Grinenko AJa, et al. Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug Alcohol Depend 33 (1993) 157-163
14. Leung N.Y., Whyte I.M., and Isbister G.K. Baclofen overdose: Defining the spectrum of toxicity. Emerg Med Australas 18 (2006) 77-82
15. Mason B.J., and Ownby R.L. Acamprosate for the treatment of alcohol dependence: A review of double-blind, placebo-controlled trials. CNS Spectr 5 (2000) 58-69
16. O'Malley S.S., Jaffe A.J., Chang G., Schottenfeld R.S., Meyer R.E., and Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatry 49 (1992) 881-887
17. Paoletti O. La prescription hors AMM. Neurologies 6 (2003) 46-49
18. Roberts D.C., and Andrews M.M. Baclofen suppression of cocaine self-administration: Demonstration using a discrete trials procedure. Psychopharmacology (Berl) 131 (1997) 271-277
19. Smith C.R., LaRocca N.G., Giesser B.S., and Scheinberg L.C. High-dose oral baclofen: Experience in patients with multiple sclerosis. Neurology 41 (1991) 1829-1831
20. Volpicelli J.R., Alterman A.I., Hayashida M., and O'Brien C.P. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49 (1992) 876-880