High performance liquid chromatographic determination of proguanil after derivatisation with sodium benzoxazole-2-sulphonate

African Journal of Biotechnology

Volumn 9, Issue 6, 2010, Pages 900-905

  Adewuyi, G O ^a   Olubomehin, O ^b   Ayanniyi, A W ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b OLABISI ONABANJO UNIVERSITY   (Nigeria)

Author keywords

Biquanide; Derivatisation; Endogeneous; Fluorensced; Proguanil

Indexed keywords

BENZOXAZOLE DERIVATIVE; CHLOROFORM; INORGANIC SALT; METHANOL; PROGUANIL; SODIUM BENZOXAZOLE 2 SULPHONATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; [(N1 (4 CHLOROPHENYL) N5 (1 METHYL ETHYL) IMIDOCARBONIMIDEAMIDE N BENZOXAZOLE;

ANALYTIC METHOD; ARTICLE; CALIBRATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHEMISTRY; CORRELATION ANALYSIS; DERIVATIZATION; EVAPORATION; EXTRACTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET RADIATION; URINALYSIS;

EID: 77249148458     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: 10.5897/ajb09.1491     Document Type: Article

References (20)

1. Bergqvist Y, Hopstadius C (2000). Simultaneous Separation of Atovaquone, Proguanil and Its Metabolites on A Mixed Mode High Performance Liquid Chromatography Column. J. Chromatogr. B. 741: 189-193.
2. Bergqvist Y, Funding L, Kaneko A, Krysen B, Leek T (1998). Improved Method for the Simultaneous Determination of Proguanil and Its Metabolites by High Performance Liquid Chromatography and Solid Phase Extraction of 100mL Capillary Blood Samples Dried on Sampling Paper. J. Chromatogr. B. 719: 141-149.
3. Bouchaud O, Monlum E, Munanza K, Fontamet A, Scott T, Goetschel A, Chulay JD, Le Bras J, Davis M, Le Bras M, Coulad JP, Gentilini M (2000). Atovaquone Plus Proguanil versus Halofantrine for the Treatment of Imported Acute Uncomplicated Plasmodium Falciparum Malaria in Non-Immune Adults: Randomised Comparative Trial. Am. J. Trop Med. Hyg. 63. 5, 6: 274-270.
4. Curd FHS, Davey DG, Rose FL (1945). Studies on Synthetic Anti-Malaria Drugs X - Some Biguanide Derivatives as New Types of Anti-Malarial Substances with both Therapeutic and Causal Prophylactic Activity. Ann. Trop. Med. Parasitol. 39: 208-216.
5. Ebeshi UB, Obodozie OO, Bolaji OO, Ogunbona AF (2005). Sensitive High Performance Liquid Chromatographic Method for the Determination of Proguanil and Its Metabolites, Cycloguanil and 4-Chlorophenyl Biguanide in Biological Fluids. Afr. J. Biotechnol. 4(8): 856-861.
6. Edstein MD (1986). Simultaneous Measurement of Proguanil and Cycloguamil in Human Plasma by High-Performance Liquid Chromatography. J. Chromatogr. 380: 184-189.
7. Gallo U, Nastasi A, Novocic L (1955). Determination of Proguanil in Non-aqueous Solvents. Bull-Chim. Farm. 94: 85-89
8. Gozal D, Hengy C, Fadat G (1991). Prolonged Malaria Prophylaxis with Chloroquine and Proguanil (Chrologuanide) in a non-immune resident population of an endemic area with high prevalence of chloroquine resistance. Antimicrob. Agents Chemother. 35(2): 373-376.
9. Green I, Barbu S (1972). The Dosage of chloroguanidine HCl. Farmacia (Bucharest). 15(1): 1-6.
10. Idowu OR, Adewuyi GO (1993). Sodium benzoxazole-2-sulphonate: A Derivatisation reagent for the analysis of amines and amino acids by HPLC with fluorescence and UV detection. J. Liquid Chromatogr. 17: 3773-3791.
11. Kelly JA, Fletcher KA (1986). High Performance Liquid Chromatographic Method for the Determination of Proguanil and Cycloguanil in Biological Fluids. J. Chromatogr. 381: 464-471.
12. Kolawole JA, Taylor RB, Moody RR (1995). Determination of Proguanil and its Metabolites in Small Sample Volumes of Whole Blood Stored on Filter Paper by High Performance Liquid Chromatography. J. Chromatogr. B. 674: 149-154.
13. Meagraith BG, Tottey MM, Adams ARD, Horner Andrews WH, King JD (1946). The Absorption and Excretion of Paludrine In The Human Subject. Ann. Trop. Med. Parasitol. 40: 495-506
14. Moody RR, Selkirk AB, Taylor RB (1982). High performance liquid chromatograph of proguanil, cycloguanil and 4-chlorophynylbiguanide using hydrophobic pairing-ion and its application to serum assay. J. Chromatogr. 182: 359-367.
15. Smith CC, Ihrig J, Menne T (1961). Anti-Malarial activity and metabolism of biguanides I.; metabolism of chlorguanide triazine in rhesus monkeys and man. Am. J. Trop. Med. 10: 694-703.
16. Stagg H (1947). Determination of N-(p-Chloro)-N-Isopropyl Biguanide. J. Pharm. Pharmacol. 1: 391-394.
17. Taylor RB, Behrens R, Moody RR, Wangbooskul J (1990). Assay method for simultaneous determination of proguanil, chloroquine and other major metabolites in biological fluids J. Chromatogr. 527: 490-497.
18. Taylor RB, Moody RR, Ochekpe NA (1987). Determination of proguanil and its metabolites cycloguanil and 4-chlorophenyl biguanide in plasma, whole blood and urine by high performance liquid chromatography. J. Chromatogr. 416: 384-399.
19. Wattanagoon Y, Taylor RB, Moody RR, Ochckpe NA, Looareesuwan S, White NJ (1987). Single dose pharmacokinetics of proguanil and its metabolites in healthy subjects. Br. J. Clin. Phamacol. 24: 175-780.
20. World Health Organization (2001). Report of WHO informal consultation on the use of antimalarial drugs.