Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-μl capillary blood samples dried on sampling paper

Journal of Chromatography B: Biomedical Applications

Volumn 719, Issue 1-2, 1998, Pages 141-149

  Bergqvist, Y ^a,b   Funding, L ^c   Kaneko, A ^d   Krysen B ^a   Leek, T ^a  

^a DALARNA UNIVERSITY   (Sweden)

^b Div Clin Pharmacol Karolinska I   (Sweden)

^c FALUN HOSPITAL   (Sweden)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

4 Chlorophenylbiguanide; Cycloguanil; Proguanil

Indexed keywords

AMMONIUM COMPOUNDS; BLOOD; CELLULOSE; DRUG PRODUCTS; ENZYMES; EXTRACTION; ION EXCHANGE; METABOLITES; SOLID SOLUTIONS;

CAPILLARY BLOOD; CHLOROPHENYLBIGUANIDE; CYCLOGUANIL; ELUTION RECOVERY; PROGUANIL; QUARTERNARY AMMONIUM COMPOUND; SAMPLING PAPER; VENOUS BLOOD;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CYCLOGUANIL; PROGUANIL;

ARTICLE; CAPILLARY BLOOD; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; METABOLITE; NORMAL HUMAN; PAPER; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TECHNIQUE; TEMPERATURE;

ANTIMALARIALS; BIGUANIDES; CAPILLARIES; CHLOROGUANIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PAPER; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TRIAZINES;

EID: 0032553395     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00382-X     Document Type: Article

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