Two novel HLA-A*0201 T-cell epitopes in avian H5N1 viral nucleoprotein induced specific immune responses in HHD mice

Veterinary Research

Volumn 41, Issue 2, 2010, Pages

  Cheung, Ying Kit ^a   Cheng, Samuel Chak Sum ^a   Ke, Yan ^a   Xie, Yong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

0201 T cell epitope; H5N1 nucleoprotein; HHD transgenic mouse model; HLA A; Influenza A virus; Single chain trimer

Indexed keywords

ANIMALIA; AVES; FLU VACCINE; INFLUENZA A VIRUS; INFLUENZAVIRUS A; MUS; MUS MUSCULUS;

DNA VACCINE; EPITOPE; HLA A ANTIGEN; INFLUENZA VACCINE; VIRUS PROTEIN;

ANIMAL; ARTICLE; BIOLISTIC TRANSFORMATION; CHEMISTRY; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; INFLUENZA VIRUS A H5N1; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; ORTHOMYXOVIRUS INFECTION; TRANSGENIC MOUSE;

ANIMALS; BIOLISTICS; EPITOPES, T-LYMPHOCYTE; HLA-A ANTIGENS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC; ORTHOMYXOVIRIDAE INFECTIONS; SPECIFIC PATHOGEN-FREE ORGANISMS; VACCINES, DNA; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77249148325     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1051/vetres/2009071     Document Type: Article

References (29)

1. Bednarek M.A., Sauma S.Y., Gammon M.C., Porter G., Tamhankar S., Williamson A.R., Zweerink H.J., The minimum peptide epitope from the influenza virus matrix protein: extra and intracellular loading of HLA-A2, J. Immunol. (1991) 147: 4047-4053.
2. Cheung Y.K., Cheng S.C.S., Sin F.W.Y., Chan K.T., Xie Y., Induction of T-cell response by a DNA vaccine encoding a novel HLA-A*0201 severe acute respiratory syndrome coronavirus epitope, Vaccine (2007) 25:6070-6077.
3. Cinatl J. Jr., Michaelis M., Doerr H.W., The threat of avian influenza A (H5N1) part IV: Development of vaccines, Med. Microbiol. Immunol. (2007) 196: 213-225. (Pubitemid 350105929)
4. Cresswell P., Ackerman A.L., Giodini A., Peaper D.R., Wearsch P.A., Mechanisms of MHC class I-restricted antigen processing and cross-presentation, Immunol. Rev. (2005) 207:145-157.
5. Dutoit V., Taub R.N., Papadopoulos K.P., Talbot S., Keohan M.L., Brehm M., et al., Multiepitope CD8(+) T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting, J. Clin. Invest. (2002) 110:1813-1822.
6. Epstein S.L., Tumpey T.M., Misplon J.A., Lo C.Y., Cooper L.A., Subbarao K., et al., DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice, Emerg. Infect. Dis. (2002) 8:796-801.
7. Epstein S.L., Kong W.P., Misplon J.A., Lo C.Y., Tumpey T.M., Xu L., Nabel G.J., Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein, Vaccine (2005) 23:5404-5410.
8. Gnjatic S., Atanackovic D., Matsuo M., Jäger E., Lee S.Y., Valmori D., et al., Cross-presentation of HLA class IU epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APC, J. Immunol. (2003) 170:1191-1196.
9. Heiny A.T., Miotto O., Srinivasan K.N., Khan A.M., Zhang G.L., Brusic V., et al., Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets, PLoS ONE (2007) 2:e1190.
10. Hiromoto Y., Yamazaki Y., Fukushima T., Saito T., Lindstrom S.E., Omoe K., et al., Evolutionary characterization of the six internal genes of H5N1 human influenza A virus, J. Gen. Virol. (2000) 81:1293-1303.
11. Horimoto T., Kawaoka Y., Strategies for developing vaccines against H5N1 influenza A viruses, Trends Mol. Med. (2006) 12:506-514.
12. Huang C.H., Peng S., He L., Tsai Y.C., Boyd D.A., Hansen T.H., et al., Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope, Gene Ther. (2005) 12:1180-1186.
13. Kodihalli S., Goto H., Kobasa D.L., Krauss S., Kawaoka Y., Webster R.G., DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice, J. Virol. (1999) 73:2094-2098.
14. Kodihalli S., Kobasa D.L., Webster R.G., Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines, Vaccine (2000) 18:2592-2599.
15. Laddy D.J., Yan J., Corbitt N., Kobasa D., Kobinger G.P., Weiner D.B., Immunogenicity of novel consensus-based DNA vaccines against avian influenza, Vaccine (2007) 25:2984-2989.
16. Leclerc D., Beauseigle D., Denis J., Morin H., Paré C., Lamarre A., Lapointe R., Proteasome-independent major histocompatibility complex class I cross-presentation mediated by papaya mosaic viruslike particles leads to expansion of specific human T cells, J. Virol. (2007) 81:1319-1326.
17. Li K.S., Guan Y., Wang J., Smith G.J., Xu K.M., Duan L., et al., Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia, Nature (2004) 430:2009-2013.
18. Middleton D., Menchaca L., Rood H., Komerofsky R., New allele frequency database: http://www.allelefre quencies.net, Tissue Antigens (2003) 61:403-407.
19. Nicholson K.G., Wood J.M., Zambon M., Influenza, Lancet (2003) 362:1733-1745.
20. Parida R., Shaila M.S., Mukherjee S., Chandra N.R., Nayak R., Computational analysis of proteome of H5N1 avian influenza virus to define T cell epitopes with vaccine potential, Vaccine (2007) 25: 7530-7539.
21. Pascolo S., Bervas N., Ure J.M., Smith A.G., Lemonnier F.A., Pérarnau B., HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice, J. Exp. Med. (1997) 185:2043-2051.
22. Rimmelzwaan G.F., Fouchier R.A., Osterhaus A.D., Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development, Curr. Opin. Biotechnol. (2007) 18:529-536.
23. Roy S., Kobinger G.P., Lin J., Figueredo J., Calcedo R., Kobasa D., Wilson J.M., Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein, Vaccine (2007) 25:6845-6851.
24. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., et al., Heterologous protection against influenza by injection of DNA encoding a viral protein, Science (1993) 259:1745-1749.
25. Wang M., Lamberth K., Harndahl M., Røder G., Stryhn A., Larsen M.V., et al., CTL epitopes for influenza A including the H5N1 bird flu: genomepathogen-, and HLA-wide screening, Vaccine (2007) 25:2823-2831.
26. Webster R.G., Bean W.J., Gorman O.T., Chambers T.M., Kawaoka Y., Evolution and ecology of influenza Aviruses, Microbiol. Rev. (1992) 56:152-179.
27. Wilson N.S., Villadangos J.A., Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications, Adv. Immunol. (2005) 86: 241-305.
28. Xie L.H., Sin F.W.Y., Cheng S.C.S., Cheung Y.K., Chan K.T., Xie Y., Xie Y., Activation of cytotoxic T lymphocytes against CML28-bearing tumors by dendritic cells transduced with a recombinant adenoassociated virus encoding the CML28 gene, Cancer Immunol. Immunother. (2008) 57:1029-1038.
29. Yu Y.Y., Netuschi N., Lybarger L., Connolly J.M., Hansen T.H., Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells, J. Immunol. (2002) 168:3145-3149.