NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 6, 2010, Pages 2479-2484

  Koutmou, Kristin S ^a   Casiano Negroni, Anette ^a   Getz, Melissa M ^a   Pazicni, Samuel ^a   Andrews, Andrew J ^b   Penner Hahn, James E ^a   Al Hashimia, Hashim M ^a   Fierke, Carol A ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Manganese; Ribozyme; RNase P; X ray absorption spectroscopy; Zinc

Indexed keywords

RIBONUCLEASE P; TRANSFER RNA; ZINC;

ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; METAL BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROENTGEN SPECTROSCOPY;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; GLYCINE; MAGNETIC RESONANCE SPECTROSCOPY; METALS; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RIBONUCLEASE P; SPECTROMETRY, X-RAY EMISSION; ZINC;

EID: 77249135842     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906319107     Document Type: Article

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