The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning

RNA

Volumn 12, Issue 8, 2006, Pages 1463-1467

  Christian, Eric L ^a   Smith, Kari M J ^a   Perera, Nicholas ^a   Harris, Michael E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Catalysis; Metal ion; RNase P; Substrate recognition

Indexed keywords

MAGNESIUM ION; RIBONUCLEASE P; RIBOZYME; RNA; TRANSFER RNA;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; METAL BINDING; POSITION EFFECT; PRIORITY JOURNAL; RNA CLEAVAGE; RNA STRUCTURE;

BINDING SITES; CADMIUM; CALCIUM; CATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNESIUM; METALS; MODELS, MOLECULAR; MUTATION; NUCLEIC ACID CONFORMATION; PHOSPHATES; RIBONUCLEASE P; RNA PRECURSORS; RNA, CATALYTIC; SUBSTRATE SPECIFICITY; TEMPERATURE;

EID: 33746538312     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.158606     Document Type: Article

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