Molecular modeling and affinity determination of scFv antibody: Proper linker peptide enhances its activity

Annals of Biomedical Engineering

Volumn 38, Issue 2, 2010, Pages 537-549

  Gu, Xin ^a   Jia, Xiaoling ^b   Feng, Jiannan ^a,c   Shen, Beifen ^a   Huang, Ying ^a   Geng, Shusheng ^a   Sun, Yingxun ^a   Wang, Yugang ^a   Li, Yan ^a,c   Long, Mian ^b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b INSTITUTE OF MECHANICS   (China)

^c HENAN UNIVERSITY   (China)

Author keywords

Binding affinity; Linker peptide; Micropipette adhesion frequency; Molecular modeling; Scatchard analysis

Indexed keywords

BINDING AFFINITIES; LINKER PEPTIDE; MICRO-PIPETTE; MICROPIPETTE ADHESION FREQUENCY; SCATCHARD ANALYSIS;

ADHESION; BINDING ENERGY; MOLECULAR MODELING; PEPTIDES;

ANTIBODIES;

PEPTIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ARTICLE; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; ULTRASTRUCTURE;

BINDING SITES; MODELS, CHEMICAL; MODELS, IMMUNOLOGICAL; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SINGLE-CHAIN ANTIBODIES;

EID: 77249135786     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-009-9810-2     Document Type: Article

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