EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas

Cancer Letters

Volumn 290, Issue 1, 2010, Pages 36-42

  Magrassi, Lorenzo ^a,b   Marziliano, Nicola ^a   Inzani, Frediano ^a   Cassini, Pamela ^a   Chiaranda, Ilaria ^a   Skrap, Miran ^c   Pizzolito, Stefano ^c   Arienta, Cesare ^a   Arbustini, Eloisa ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b CNR   (Italy)

^c SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

Author keywords

Choroid plexus papilloma; EDG3; Ependymoma; Gene amplification; SHC3

Indexed keywords

CHROMOSOME PROTEIN; GLYCOSIDASE; PROTEIN EDG3; PROTEIN SCH3; PROTEIN SHC; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 9Q; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM; EPENDYMOMA; GENE AMPLIFICATION; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION;

BLOTTING, WESTERN; CHROMOSOMES, HUMAN, PAIR 9; EPENDYMOMA; GENE AMPLIFICATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION, FLUORESCENCE; POLYMERASE CHAIN REACTION; RECEPTORS, LYSOSPHINGOLIPID; SHC SIGNALING ADAPTOR PROTEINS;

EID: 77249100197     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.023     Document Type: Article

References (23)

1. R.E. McLendon, O.D. Wiestler, J.M. Kros, A. Korshunov, H.K. Ng, Ependymoma, in: D.N. Louis, H. Ohgaki, O.D. Wiestler, W.K. Cavanee, (Eds.), WHO classification of Tumours of the Central Nervous System, International Agency for Research on Cancer, Lyon, 2007, pp. 74-78.
2. Zheng P.P., Pang J.C., Hui A.B., and Ng H.K. Comparative genomic hybridization detects losses of chromosomes 22 and 16 as the most common recurrent genetic alterations in primary ependymomas. Cancer Genet. Cytogenet. 122 (2000) 18-25
3. Mahler-Araujo M.B., Sanoudou D., Tingby O., Liu L., Coleman N., Ichimura K., et al. Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomas. J. Neuropathol. Exp. Neurol. 62 (2003) 927-935
4. Rickert C.H., Wiestler O.D., and Paulus W. Chromosomal imbalances in choroid plexus tumors. Am. J. Pathol. 160 (2002) 1105-1113
5. Magrassi L., Conti L., Lanterna A., Zuccato C., Marchionni M., Cassini P., et al. Shc3 affects human high-grade astrocytomas survival. Oncogene 24 (2005) 5198-5206
6. Nigro J.M., Takahashi M.A., Ginzinger D.G., Law M., Passe S., Jenkins R.B., et al. Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay. Am. J. Pathol. 158 (2001) 1253-1262
7. Heid C.A., Stevens J., Livak K.J., and Williams P.M. Real time quantitative PCR. Genome Res. 6 (1996) 986-994
8. Schofield D., West D.C., Anthony D.C., Marshal R., and Sklar J. Correlation of loss of heterozygosity at chromosome 9q with histological subtype in medulloblastomas. Am. J. Pathol. 146 (1995) 472-480
9. Kohono T., and Igarashi Y. Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. Glycoconj. J. 21 (2004) 497-501
10. Garcia J.G., Liu F., Verin A.D., Birukova A., Dechert M.A., Gerthoffer W.T., et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest. 108 (2001) 689-701
11. Conti L., Sipione S., Magrassi L., Bonfanti L., Rigamonti D., Pettirossi V., et al. Shc signaling in differentiating neural progenitor cells. Nat. Neurosci. 4 (2001) 579-586
12. Tanimoto T., Lungu A.O., and Berk B.C. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res. 94 (2004) 1050-1058
13. Means C.K., Xiao C.Y., Li Z., Zhang T., Omens J.H., Ishii I., et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H2944-H2951
14. Miyamoto Y., Chen L., Sato M., Sokabe M., Nabeshima T., Pawson T., et al. Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J. Neurosci. 25 (2005) 1826-1835
15. Tarr P.E., Roncarati R., Pelicci G., Pelicci P.G., and D'Adamio L. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277 (2002) 16798-16804
16. Pelicci G., Troglio F., Bodini A., Melillo R.M., Pettirossi V., Coda L., et al. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. Mol. Cell. Biol. 22 (2002) 7351-7363
17. Miyake I., Hakomori Y., Misu Y., Nakadate H., Matsuura N., Sakamoto M., et al. Domain-specific function of ShcC docking protein in neuroblastoma cells. Oncogene 24 (2005) 3206-3215
18. Mendrzyk F., Korshunov A., Benner A., Toedt G., Pfister S., Radlwimmer B., et al. Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. Clin. Cancer Res. 12 (2006) 2070-2079
19. Modena P., Lualdi E., Facchinetti F., Veltman J., Reid J.F., Minardi S., et al. Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics. J. Clin. Oncol. 24 (2006) 5223-5233
20. Rousseau E., Palm T., Scaravilli F., Ruchoux M.M., Figarella-Branger D., Salmon I., et al. Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. Mol. Cancer 6 (2007) 47
21. Taylor M.D., Poppleton H., Fuller C., Su X., Liu Y., Jensen P., et al. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 8 (2005) 323-335
22. Scheil S., Bruderlein S., Eicker M., Herms J., Herold-Mende C., Steiner H.H., et al. Low frequency of chromosomal imbalances in anaplastic ependymomas as detected by comparative genomic hybridization. Brain Pathol. 11 (2001) 133-143
23. Huang B., Starostik P., Schraut H., Krauss J., Sörensen N., and Roggendorf W. Human ependymomas reveal frequent deletions on chromosomes 6 and 9. Acta Neuropathol. 106 (2003) 357-362