Synthesis, metabolism and in vitro cytotoxicity studies on novel lavendamycin antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1899-1909

  Cai, Wen ^a   Hassani, Mary ^b   Karki, Rajesh ^a   Walter, Ervin D ^a   Koelsch, Katherine H ^b   Seradj, Hassan ^a   Lineswala, Jayana P ^a   Mirzaei, Hamid ^a   York, Jeremy S ^a   Olang, Fatemeh ^a   Sedighi, Minoo ^a   Lucas, Jennifer S ^a   Eads, Thomas J ^a   Rose, Anthony S ^a   Charkhzarrin, Sahba ^a   Hermann, Nicholas G ^a   Beall, Howard D ^b   Behforouz, Mohammad ^a  

^a BALL STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MONTANA   (United States)

Author keywords

Antitumor; Cytotoxicity; Lavendamycin analogues; NQO1; Quinoline 5,8 diones

Indexed keywords

2 FORMYLQUINOLINE 5,8 DIONE DERIVATIVE; 6 CHLORODEMETHYLLAVENAMYCIN ETHYL ESTER; 7 N (2 FURYL) CARBONYLLAVENDAMYCIN METHYLESTER; 7 N (3 CARBOXYPROPIONYL) DEMETHYLLAVENDAMYCIN N BUTYLESTER; 7 N ACETYL 110 HYDROXYDEMETHYLLAVENDAMYCIN ETHYLESTER; 7 N ACETYL 110 HYDROXYDEMETHYLLAVENDAMYCIN ISOAMYLESTER; 7 N ACETYL 110 HYDROXYLAVENDAMYCIN METHYLESTER; 7 N ACETYLDEMETHYLLAVENDAMYCIN 2,3 DIHYDROXYPROPANAMIDE; 7 N ACETYLDEMETHYLLAVENDAMYCIN N PROPYLESTER; 7 N ACETYLDEMETHYLLAVENDMYCIN N BENZYLPIPERAZINE AMIDE; 7 N CHLOROACETYLDEMETHYLLAVENDAMYCIN AMIDE; 7 N CHLOROACETYLDEMETHYLLAVENDAMYCIN PYRROLIDINE AMIDE; 7 N DEMETHYLLAVENDAMYCIN 2 HYDROXYETHANAMIDE; 7 N FORMYLDEMETHYLLAVENDAMYCIN METHYLESTER; ANTINEOPLASTIC AGENT; LAVENDAMYCIN; N ACETYLDEMETHYLLAVENDAMYCIN SEC BUTYLESTER; NADPH QUINONE OXIDOREDUCTASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; POLYMERIZATION; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; NAD(P)H DEHYDROGENASE (QUINONE); RECOMBINANT PROTEINS; STREPTONIGRIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249092993     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.037     Document Type: Article

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