Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A2 expression through MAPK/NF-κB inactivation

Biochemical Pharmacology

Volumn 79, Issue 8, 2010, Pages 1149-1155

  Raymond, Benoit ^a,b   Ravaux, Lucas ^c   Mémet, Sylvie ^a,d   Wu, YongZheng ^a,b   Sturny Leclère, Aude ^a,d   Leduc, Dominique ^a,b   Denoyelle, Chantal ^c   Goossens, Pierre L ^a,d   Payá, Miguel ^e   Raymondjean, Michel ^c   Touqui, Lhousseine ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Anthrax; Macrophages; MAPK kinase; NF B; Phospholipase A2

Indexed keywords

ANTHRAX TOXIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NUCLEAR PROTEIN; SECRETORY PHOSPHOLIPASE A2;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CELL NUCLEUS; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENETIC TRANSFECTION; GUINEA PIG; HOST RESISTANCE; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TOXIN SYNTHESIS; TRANSACTIVATION; WESTERN BLOTTING;

EID: 77249083561     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.11.023     Document Type: Article

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