Alveolar stability under different combinations of positive end-expiratory pressure and tidal volume: Alveolar microscopy in isolated injured rat lungs

Chinese Medical Journal

Volumn 123, Issue 4, 2010, Pages 406-411

  Liu, Hui ^a,b   Stahl, Claudius A ^b   Moeller, Knut ^c   Schneider, Matthias ^b   Ganzert, Steven ^b   Zhao, Zhan Qi ^c   Tong, Xiao Wen ^d   Guttmann, Josef ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF FREIBURG   (Germany)

^c FURTWANGEN UNIVERSITY   (Germany)

^d TONGJI UNIVERSITY   (China)

Author keywords

Alveolar mechanics; Alveolar microscopy; Positive end expiratory pressure; Tidal volume

Indexed keywords

ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; FEMALE; ISOLATED LUNG; LUNG ALVEOLUS; LUNG INJURY; LUNG VENTILATION; MICROSCOPY; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; RAT; TIDAL VOLUME;

ANIMALS; FEMALE; LUNG; LUNG INJURY; MICROSCOPY; PULMONARY ALVEOLI; RATS; RATS, WISTAR; TIDAL VOLUME;

EID: 77149171157     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.04.005     Document Type: Article

References (18)

1. Tschumperlin DJ, Oswari J, Margulies AS. Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am J Respir Crit Care Med 2000; 162: 357-362.
2. Hubmayr RD. Perspective on lung injury and recruitment. A skeptical look at the opening and collapse story. Am J Respir Crit Care Med 2002; 165: 1647-1653.
3. Lachmann B. Open the lung and keep the lung open. Intensive Care Med 1992; 18: 319-321.
4. Ricard JD, Dreyfuss D, Saumon G. Ventilator-induced lung injury. Eur Respir J Suppl 2003; 42: 2-9.
5. Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 1998; 157: 1159-1164.
6. Slutsky AS. Mechanical ventilation. American College of Chest Physicians' Consensus Conference. Chest 1993; 104: 1833-1859.
7. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338: 347-354.
8. Halter JM, Steinberg JM, Gatto LA, DiRocco JD, Pavone LA, Schiller HJ, et al. Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability. Crit Care 2007; 11: 20-32.
9. Stahl C, Schumann S, Knorpp H, Schneider M, Möller K, Guttmann J. Intravital endoscopy of alveoli: a new method to visualize the mechanical alveolar dynamics. J Biomech 2006; 39 (Suppl 1): 598.
10. DiRocco JD, Pavone LA, Carney DE, Lutz CJ, Gatto LA, Landas SK, et al. Dynamic alveolar mechanics in four models of lung injury. Intensive Care Med 2006; 32: 140-148.
11. Steinberg J, Schiller HJ, Halter JM, Gatto LA, Dasilva M, Amato M, et al. Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation. Crit Care Med 2002; 30: 2675-2683.
12. Gatto LA, Fluck RR Jr. Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury. Respir Care 2004; 49: 1045-1055.
13. Kitaoka H, Nieman GF, Fujino Y, Carney D, Dirocco J, Kawase I. A 4-dimensional model of the alveolar structure. J Physiol Sci 2007; 57: 175-185.
14. Hickling KG, Henderson SJ, Jackson R. Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. Intensive Care Med. 1990; 16: 372-377.
15. The Acute Respiratory Distress Syndrome Network: ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
16. Schiller HJ, McCann UG 2nd, Carney DE, Gatto LA, Steinberg JM, Nieman GF. Altered alveolar mechanics in the acutely injured lung. Crit Care Med 2001; 29: 1049-1055.
17. Nieman GF, Bredenberg CE, Clark WR, West NR. Alveolar function following surfactant deactivation. J Appl Physiol 1981; 51: 895-904.
18. Perlman CE, Bhattacharya J. Alveolar expansion imaged by optical sectioning microscopy. J Appl Physiol 2007; 103: 1037-1044.