Cell-based screening and validation of human novel gene TMEM9B activated nuclear factor κB signaling pathway;Cell-based screening and validation of human novel gene TMEM9B activated nuclear factor κB signaling pathway

Progress in Biochemistry and Biophysics

Volumn 36, Issue 11, 2009, Pages 1423-1428

  Liu, Yu Ming ^a,c   Peng, Zhi ^a   Deng, Wei Wei ^a   Shi, Tai Ping ^a,b   Ma, Da Long ^a,b  

^a CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c INNER MONGOLIA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Cell apoptosis; Cell based screening; NF B; TMEM9B

Indexed keywords

EID: 77149158803     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2009.00256     Document Type: Article

References (19)

1. Giese K, Kaufmann J, Pronk G J, et al. Unravelling novel intracellular pathways in cell-based assays. Drug Discovery Today, 2002, 7(3): 179-186
2. Karin M, Yamamoto Y, Wang Q M. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov, 2004, 3 (1): 17-26
3. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF- [kappa]B activity. Annu Rev Immunol, 2000, 18: 621-663
4. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol, 2002, 3(3): 221-227
5. Dutta J, Fan Y, Gupta N, et al. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene, 2006, 25(51): 6800-6816
6. Bian X, McAllister-Lucas LM, Shao F, et al. NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J Biol Chem, 2001, 276(52): 48921-48929
7. Hettmann T, DiDonato J, Karin M, et al. An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med, 1999, 189(1): 145-158
8. Campbell K J, Rocha S, Perkins N D. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell, 2004, 13(6): 853-865
9. Bessho R, Matsubara K, Kubota M, et al. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor kappa B (NF-kappa B) activation, prevents apoptosis in human promyelocyte leukemia HL-60 cells and thymocytes. Biochem Pharmacol, 1994,48(10): 1883-1889
10. Zingarelli B, Sheehan M, Hector R. et al. Nuclear factor-kappaB as a therapeutic target in critical care medicine. Crit Care Med, 2003, 31 (1 Suppl): S105-S111
11. Richmond A. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol, 2002,2(9): 664-674
12. Karin M, Cao Y, Greten F R, et al. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer, 2002, 2(4): 301-310
13. Sonnhammer E L, von Heijne G, Krogh A. A hidden Markov model for predicting transmembrane helices in protein sequences. Proc Int Conf Intell SystMol Biol, 1998, 6: 175-182
14. Lukashin A V, Borodovsky M. GeneMark.hmm: new solutions for gene finding. Nucleic Acids Res, 1998, 26(4): 1107-1115
15. Su A I, Wiltshire T, Batalov S, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA, 2004, 101(16): 6062-6067
16. Dodeller F, Gottar M, Huesken D, et al. the lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. J Biol Chem, 2008, 283(31): 21487-21494
17. Calzado M A, Bacher S, Schmitz M L. NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem, 2007,14(3): 367-376
18. Camandola S, Mattson M P. NF-kappa B as a therapeutic target in neurodegenerative diseases. Expert Opin Ther Targets, 2007, 11(2): 123-132
19. O'Sullivan B, Thompson A, Thomas R. NF-kappa B as a therapeutic target in autoimmune disease. Expert Opin Ther Targets, 2007, 11 (2): 111-122