Connective tissue growth factor knockdown attenuated matrix protein production and vascular endothelial growth factor expression induced by transforming growth factor-β1 in cultured human peritoneal mesothelial cells

Therapeutic Apheresis and Dialysis

Volumn 14, Issue 1, 2010, Pages 27-34

  Xiao, Li ^a   Sun, Lin ^a   Liu, Fu You ^a   Peng, You Ming ^a   Duan, Shao Bin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Connective tissue growth factor; Human peritoneal mesothelial cell; Peritoneal fibrosis; Short hairpin RNA; Transforming growth factor 1

Indexed keywords

COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CONNECTIVE TISSUE GROWTH FACTOR SHORT HAIRPIN RNA; FIBRONECTIN; LAMININ; MATRIX PROTEIN; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; EXPRESSION VECTOR; EXTRACELLULAR MATRIX; GENE CONSTRUCT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INCUBATION TIME; MESOTHELIUM CELL; PERITONEUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; VIRUS PARTICLE; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DOWN-REGULATION; EPITHELIUM; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; PERITONEUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77149157488     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2009.00701.x     Document Type: Article

References (25)

1. Lin CY, Chen WP, Yang LY et al. Persistent transforming growth factor-beta 1 expression may predict peritoneal fibrosis in CAPD patients with frequent peritonitis occurrence. Am J Nephrol 1998 18 : 513 519.
2. Margetts PJ, Kolb M, Galt T et al. Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J Am Soc Nephrol 2001 12 : 2029 2039.
3. Margetts PJ, Oh KH, Kolb M. Transforming growth factor-beta: importance in long-term peritoneal membrane changes. Perit Dial Int 2005 25 (Suppl. 3) S15 7.
4. Hung KY, Chen CT, Huang JW et al. Dipyridamole inhibits TGF-beta-induced collagen gene expression in human peritoneal mesothelial cells. Kidney Int 2001 60 : 1249 1257.
5. Imai H, Nakamoto H, Fucshima R et al. Glucocorticoid protects against the development of encapsulating peritoneal sclerosis on peritoneal dialysis. Adv Perit Dial 2002 18 : 124 130.
6. Liu FY, Ling GH, Liu H et al. Inhibiting effect of short hairpin RNA on expression of transforming growth factor-beta1 in human peritoneal mesothelial cells induced by peritoneal dialysis solution. Chin Med J 2005 118 : 1552 1556.
7. Border WA, Noble NA. TGF-β in kidney fibrosis: a target for gene therapy. Kidney Int 1997 51 : 1388 1396.
8. Lawrence DA. Transforming growth factor-beta: an overview. Kidney Int Suppl 1995 49 : S19 23.
9. Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J 2004 18 : 816 827.
10. Kobayashi T, Inoue T, Okada H et al. Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose. Clin Exp Nephrol 2005 9 : 114 121.
11. Chujo S, Shirasaki F, Kawara S et al. Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. J Cell Physiol 2005 203 : 447 456.
12. Zarrinkalam KH, Stanley JM, Gray J et al. Connective tissue growth factor and its regulation in the peritoneal cavity of peritoneal dialysis patients. Kidney Int 2003 64 : 331 338.
13. Sakamoto N, Sugimura K, Kawashima H et al. Influence of glucose and inflammatory cytokines on TGF-beta1 and CTGF mRNA expressions in human peritoneal mesothelial cells. Int J Mol Med 2005 15 : 907 911.
14. Zhang H, Liu FY, Liu YH. Effect of TGF-beta1 stimulation on the smad signal transduction pathway of human peritoneal mesothelial cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2004 29 : 142 147.
15. Szeto CC, Lai KB, Chow KM et al. Differential effects of transforming growth factor-beta on the synthesis of connective tissue growth factor and vascular endothelial growth factor by peritoneal mesothelial cell. Nephron Exp Nephrol 2005 99 : e95 104.
16. Chen W, Fu X, Sheng Z. Review of current progress in the structure and function of Smad proteins. Chin Med J 2002 115 : 446 450.
17. Kothapalli D, Grotendorst GR. CTGF modulates cell cycle progression in cAMP-arrested NRK fibroblasts. J Cell Physiol 2000. 182 : 111 126.
18. Jedsadayanmata A, Chen CC, Kireeva ML et al. Activation dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha (IIb) beta. J Biol Chem 1999 274 : 24321 24327.
19. Gunal AI, Celiker H, Akpolat N et al. By reducing production of vascular endothelial growth factor octreotide improves the peritoneal vascular alterations induced by hypertonic peritoneal dialysis solution. Perit Dial Int 2002 22 : 301 306.
20. Motomura Y, Kanbayashi H, Khan WI et al. The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta type II receptor gene transfer. Am J Physiol Gastrointest Liver Physiol 2005 288 : G143 50.
21. Yoshio Y, Miyazaki M, Abe K et al. TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. Kidney Int 2004 66 : 1677 1685.
22. Brigstock DR. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 2002 5 : 153 165.
23. Chang CC, Lin MT, Lin BR et al. Effect of connective tissue growth factor on hypoxia-inducible factor lalpha degradation and tumor angiogenesis. J Natl Cancer Inst 2006 98 : 984 995.
24. Watanabe D, Takagi H, Suzuma K et al. Expression of connective tissue growth factor and its potential role in choroidal neovascularization. Retina 2005 25 : 911 918.
25. Kita T, Hata Y, Miura M et al. Functional characteristics of connective tissue growth factor on vitreoretinal cells. Diabetes 2007 56 : 1421 1428.