Payment to healthy volunteers in clinical research: The research subject's perspective

Clinical Pharmacology and Therapeutics

Volumn 87, Issue 3, 2010, Pages 286-293

  Czarny, M J ^a   Kass, N E ^b,c   Flexner, C ^a   Carson, K A ^c   Myers, R K ^d   Fuchs, E J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL RESEARCH; COMPENSATION; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; INTERVIEW; MALE; NORMAL HUMAN; PERCEPTION; PRIORITY JOURNAL; RISK ASSESSMENT;

ADOLESCENT; ADULT; BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; DATA COLLECTION; FEMALE; HUMAN EXPERIMENTATION; HUMANS; MALE; MIDDLE AGED; PATIENT SELECTION; RESEARCH SUBJECTS; YOUNG ADULT;

EID: 77149150004     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.222     Document Type: Article

References (20)

1. McNeill, P. Paying people to participate in research: why not? a response to Wilkinson and Moore. Bioethics 11, 390-396 (1997).
2. Latterman, J. & Merz, J.F. how much are subjects paid to participate in research? Am. J. Bioeth. 1, 45-46 (2001).
3. Macklin, R. On paying money to research subjects: 'due' and 'undue' inducements. IRB 3, 1-6 (1981).
4. Dickert, N. & Grady, C. What's the price of a research subject? approaches to payment for research participation. N. Engl. J. Med. 341, 198-203 (1999).
5. Ackerman, T.F. An ethical framework for the practice of paying research subjects. IRB 11, 1-4 (1989).
6. Lemmens, T. & Elliott, c. Guinea pigs on the payroll: the ethics of paying research subjects. Account. Res. 7, 3-20 (1999).
7. Chaput de Saintonge, D.M., Crane, G.J., Rust, N.D., Karadia, S. & Whittam, L.R. Modelling determinants of expected rewards in healthy volunteers. Pharmaceut. Med. 3, 45-54 (1988).
8. Kass, N.E., Myers, R., Fuchs, E.J., Carson, K.A. & Flexner, C. Balancing justice and autonomy in Clinical research with healthy volunteers. Clin. Pharmacol. Ther. 82, 219-227 (2007).
9. Institutional Review Board, Johns hopkins Medicine. Organization Policy on Payment or Remuneration to human Subjects (policy no. 111.2). accessed 2 april 2009.
10. Institutional Review Board, University of Washington. Subject Payment Guidance. accessed 2 april 2009.
11. Office for Protection of Research Subjects, University of california, Los angeles. Payment for Participation in Research. accessed 2 april 2009.
12. Office of Regulatory afairs, University of Pennsylvania. Guidance on Payment to Subjects Participating in Research. accessed 2 april 2009.
13. Committee on human Research, University of california, San Francisco. Guidelines for Payment of Research Subjects. accessed 2 april 2009.
14. Sibille, M., Deigat, N., Janin, a., Kirkesseli, S. & Durand, D.V. adverse events in phase-I studies: a report in 1015 healthy volunteers. Eur. J. Clin. Pharmacol. 54, 13-20 (1998).
15. Zarafonetis, c.J. et al. Clinically significiant adverse efects in a Phase 1 testing program. Clin. Pharmacol. Ther. 24; 127-132 (1978).
16. Verheggen, F.W., Nieman, F. & Jonkers, R. Determinants of patient participation in Clinical studies requiring informed consent: why patients enter a Clinical trial. Patient Educ. Couns. 35, 111-125 (1998).
17. Dunn, L.B. & Gordon, N.E. Improving informed consent and enhancing recruitment for research by understanding economic behavior. JAMA 293, 609-612 (2005).
18. Bigorra, J. & Baños, J.E. Weight of fnancial reward in the decision by medical students and experienced healthy volunteers to participate in Clinical trials. Eur. J. Clin. Pharmacol. 38, 443-446 (1990).
19. Cunny, K.A. & Miller, H.W. Participation in Clinical drug studies: motivations and barriers. Clin. Ther. 16, 273-82; discussion 271 (1994).
20. van Gelderen, C.E., Savelkoul, T.J., van Dokkum, W. & Meulenbelt, J. Motives and perception of healthy volunteers who participate in experiments. Eur. J. Clin. Pharmacol. 45, 15-21 (1993).