Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia

High Altitude Medicine and Biology

Volumn 10, Issue 4, 2009, Pages 373-381

  Lopez, Vasthi ^a   Siques, Patricia ^a   Brito, Julio ^a   Vallejos, Carmen ^a   Naveas, Nelson ^a   Carvallo, Claudia ^a   León Velarde, Fabiola ^b   Carvajal, Nelson ^c  

^a UNIVERSIDAD ARTURO PRAT   (Chile)

^b UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^c UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Arginase; Hypobaria; Intermittent hypoxia; Systemic hypertension; Tolerance to high altitude

Indexed keywords

ARGINASE; ARGINASE 1; ARGINASE 2; BIOLOGICAL MARKER; ISOENZYME; UNCLASSIFIED DRUG;

ALTITUDE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE OVEREXPRESSION; HEMATOCRIT; HYPERTENSION; HYPOBARISM; HYPOXIA; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMULATION; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION; WISTAR RAT;

ACCLIMATIZATION; ALTITUDE; ANIMALS; ANOXIA; ARGINASE; ATMOSPHERIC PRESSURE; BLOOD PRESSURE; BODY WEIGHT; HEART RATE; HEMATOCRIT; HYPERTENSION; LUNG; MALE; MYOCARDIUM; NITRATES; NITRITES; RATS; RATS, WISTAR; UP-REGULATION;

EID: 77049122292     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2008.1072     Document Type: Article

References (42)

1. Albina J.E., Mahoney E.J., Daley J.M., Wesche D.E., Morris S.M. Jr., and Reichner J.S. 2005 Macrophage arginase regulation by CCAAT=enhancer-binding protein beta. Shock 23 168-172.
2. Amano H., Maruyama K., Naka M., and Tanaka T. 2003 Target validation in hypoxia-induced vascular remodeling using transcriptome=metabolome analysis. Pharmacogenomics J. 3 183-188.
3. Archibald R.M. 1957 Colorimetric measurement of uric acid. Clin. Chem. 3102-105.
4. Bagnost T., Berthelot A., Bouhaddi M., Laurant P., André C., Guillaume Y., and Demougeot C. 2008 Treatment with the arginase inhibitor Nomega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. J. Hypertens. 261110-1118.
5. Bradford M.M. 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 7248-254.
6. Brito J., Siques P., León-Velarde F., De la Cruz J., Barlaro T., López V., and Herruzo R. 2008 Varying exposure to long chronic intermittent hypoxia exert different outcomes and morphological effects on Wister rats at 4600 m. Toxicol. Environ. Chem. 90169-179.
7. Brito J., Siques P., Leon-Velarde F., De La Cruz J.J., Lopez V., and Herruzo R. 2007 Chronic intermittent hypoxia at high altitude exposure for over 12 years assessment of hematological, cardiovascular, and renal effects. High Alt. Med. Biol. 8236-244.
8. Chowdhury S., Gotoh T., Mori M., and Takiguchi M. 1996 CCAAT=enhancer-binding protein beta C=EBP beta) binds and activates while hepatocyte nuclear factor-4 HNF-4) does not bind but represses the liver-type arginase promoter. Eur. J. Biochem. 236500-509.
9. Costa L.E., Boveris A., Koch O.R., and Taquini A.C. 1988 Liver and heart mitochondria in rats submitted to chronic hypobaric hypoxia. Am. J. Physiol. Cell Physiol. 255C123-C129.
10. Demougeot C., Prigent-Tessier A., Bagnost T., Andre C., Guillaume Y., Bouhaddi M., Marie C., and Berthelot A. 2007 Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Life Sci. 801128-1134.
11. Demougeot C., Prigent-Tessier A., Marie C., and Berthelot A. 2005 Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. J. Hypertens. 23971-978.
12. Durante W., Johnson F.K., and Johnson R.A. 2007 Arginase a critical regulator of nitric oxide synthesis and vascular function. Clin. Exp. Pharmacol. Physiol. 34906-911.
13. Fagan K.A., Morrissey B., Fouty B.W., Sato K., Harral J.W., Morris K.G., Jr., Hoedt-Miller M., Vidmar S., McMurtry I.F., and Rodman D.M. 2001 Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir. Res. 2306-313.
14. Franko A., Mayer S., Thiel G., Mercy L., Arnould T., Hornig-Do H., Wiesner R.J., and Goffart S. 2008 CREB-1 is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol. Cell. Biol. 28 2446-2459.
15. Germack R., León-Velarde F., Valdes De La Barra R., Farias J., Soto G., and Richalet J.P. 2002 Effect of intermittent hypoxia on cardiovascular function, adrenoceptors and muscarinic receptors in Wistar rats. Exp. Physiol. 87453-460.
16. Grover R.F., Vogel J.H., Averil K.H., and Blount S.G. 1963 Pulmonary hypertension individual and species variability relative to vascular reactivity. Am. Heart J. 661-3.
17. Gutsaeva D.R., Carraway M.S., Suliman H.B., Demchenko I.T., Shitara H., Yonekawa H., and Piantadosi C.A. 2008 Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J. Neurosci. 282015-2024.
18. Holowatz L.A., and Kenney W.L. 2007 Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans. J. Physiol. 1863-872.
19. Iyamu E.W., Ekekezie C., and Woods G.M. 2007 In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes. Brit. J. Haematol. 139337-343.
20. Jhons C., Gavras I., Handy D.E., Salomao A., and Gavras H. 1996 Model of experimental hypertension in mice. Hypertension. 281064-1069.
21. Johnson F.K., Johnson R.A., Peyton K.J., and Durante W. 2005 Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288R1057-R1062.
22. Laursen B.E., Dam M.Y., Mulvany M.J., and Simonsen U. 2008 Hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy is unaltered by long-term oral Larginine administration. Vascul. Pharmacol. 4971-76.
23. León-Velarde F., Gamboa A., Chuquiza J.A., Esteba W.A., Rivera-Chira M., and Monge C.C. 2000 Hematological parameters in high altitude residents living at 4,355, 4,660, and 5,500 meters above sea level. High Alt. Med. Biol. 197-104.
24. Louis C.A., Reichner J.S., Henry W.L., Jr., Mastrofrancesco B., Gotoh T., Mori M., and Albina J.E. 1998 Distinct arginase isoforms expressed in primary and transformed macrophages regulation by oxygen tension. Am. J. Physiol. 274 775-782.
25. Maarsingh H., Pera T., and Meurs H. 2008 Arginase and pulmonary diseases. Naunyn Schmiedebergs. Arch. Pharmacol. 378171-184.
26. Maggiorini M., and León-Velarde F. 2003 High-altitude pulmonary hypertension a pathophysiological entity to different disease. Eur. Respir. J. 221019-1025.
27. Morris C.R. 2006 New strategies for the treatment of pulmonary hypertension in sickle cell disease. The rationale for arginine therapy. Treat. Respir. Med. 531-45.
28. Nishio M.L., Ornatsky O.I., Craig E.E., and Hood D.A. 1995 Mitochondrial biogenesis during pressure overload induced cardiac hypertrophy in adult rats. Can. J. Physiol. Pharmacol. 573630-637.
29. Peñaloza D., and Arias-Stella J. 2007 The heart and pulmonary circulation at high altitudes healthy highlanders and chronic mountain sickness. Circulation .1151132-1146.
30. Radomski M.W., Vallance P., Whitley G., Foxwell N., and Moncada S. 1993 Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide. Cardiovasc. Res. 271380-1382. (Pubitemid 23250924)
31. Richalet J.P., Donoso M.V., Jimenez D., Antezana A.M., Hudson C., Cortes G., Osorio J., and León A. 2002 Chilean miners commuting from sea level to 4500 m a prospective study. High Alt. Med. Biol. 3159-166.
32. Said H.M., Hagemann C., Stojic J., Schoemig B., Vince G.H., Flentje M., Roosen K., and Vordermark D. 2007 GAPDH is not regulated in human glioblastoma under hypoxic conditions. BMC Mol. Biol. 27855.
33. Sarybaev A.S., Palasiewicz G., Usupbaeva D.A., Plywaczewski R., Maripov A.M., Sydykov A.S., Mirrakhimov M.M., Le Roux H., Kadyrov T., and Zielinski J. 2003 Effects of intermittent exposure to high altitude on pulmonary hemodynamics a prospective study. High Alt. Med. Biol. 4455-463.
34. Sasaki A., Doi S., Mizutani S., and Azuma H. 2007 Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 292L1480-L1487.
35. Siques P., Brito J., León-Velarde F., Barrios L., Cruz J.J., and López V. 2006 Time course of cardiovascular and hematological responses in rats exposed to chronic intermittent hypobaric hypoxia 4600 m High Alt. Med. Biol. 772-80.
36. Topal G., Brunet A., Walch L., Boucher J.L., and David-Dufilho M. 2006 Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. J. Pharmacol. Exp. Ther. 3181368-1374.
37. Vanhoutte P.M., and Mombouli J.V. 1996 Vascular endothelium vasoactive mediators. Prog. Cardiovasc. Dis. 39229-238.
38. Vijayasarathy C., Damle S., Prabu S.K., Otto C.M., and Avadhani N.G. 2003 Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia. Eur. J. Biochem. 270871-879.
39. Xu W., Kaneko F.T., Zheng S., Comhair S.A., Janocha A.J., Goggans T., Thunnissen F.B., Farver C., Hazen S.L., Jennings C., Dweik R.A., Arroliga A.C., and Erzurum S.C. 2004 Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J. 181746-1758.
40. Yin W., Signore A., Iwai M., Cao G., Yanqin G., and Chen J. 2008 Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. Stroke. 393057.
41. Zhang C., Hein T.W., Wang W., Miller M.W., Fossum T.W., McDonald M.M., Humphrey J.D., and Kuo L. 2004 Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension. 44935-943.
42. Zhong H., and Simons J.W. 1999 Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia. Biochem. Biophys. Res. Commun. 259523-526.