Viral vectors for the treatment of alcoholism: Use of metabolic flux analysis for cell cultivation and vector production

Metabolic Engineering

Volumn 12, Issue 2, 2010, Pages 129-137

  Martinez, V ^a   Gerdtzen, Z P ^a   Andrews, B A ^a   Asenjo, J A ^a  

^a Centre for Biochemical Engineering and Biotechnology   (Chile)

Author keywords

Adenovirus equation; Media design; Metabolic flux analysis

Indexed keywords

ACCUMULATION RATES; ADENOVIRUS VECTOR; AQUEOUS TWO PHASE SYSTEM; CELL CONCENTRATIONS; CELL CULTIVATION; CULTURE MEDIA; DESIGN TOOL; GLUCOSE CONSUMPTION; GROWTH PHASE; HEK293 CELLS; INHIBITORY EFFECT; MEDIA DESIGN; METABOLIC DEMANDS; METABOLIC FLUX ANALYSIS; METABOLIC STATE; SCALE-UP; SERUM-FREE MEDIA; STOICHIOMETRIC EQUATION; VIRAL VECTORS; VIRUS PURIFICATION;

AMINO ACIDS; CELL GROWTH; CHROMATOGRAPHIC ANALYSIS; CULTIVATION; GENE THERAPY; GENETIC ENGINEERING; GLUCOSE; GROWTH KINETICS; METABOLISM; OPTIMIZATION; VIRUSES;

CELL CULTURE;

ADENOVIRUS VECTOR;

ALCOHOLISM; ARTICLE; CELL GROWTH; CELL STRAIN HEK293; GENE THERAPY; HUMAN; HUMAN CELL; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; PRIORITY JOURNAL; STOICHIOMETRY;

ADENOVIRIDAE; CELL CULTURE TECHNIQUES; CELL LINE; CULTURE MEDIA, SERUM-FREE; EMBRYO, MAMMALIAN; GENETIC VECTORS; GLUCOSE; GLUTAMINE; HUMANS; KIDNEY; LACTATES; MODELS, BIOLOGICAL; TIME FACTORS; VIRUS CULTIVATION;

ADENOVIRIDAE;

EID: 77049107316     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.09.003     Document Type: Article

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