Zinc(II) complexes of 2-acetyl pyridine 1-(4-fluorophenyl)-piperazinyl thiosemicarbazone: Synthesis, spectroscopic study and crystal structures - Potential anticancer drugs

Journal of Inorganic Biochemistry

Volumn 104, Issue 4, 2010, Pages 467-476

  Stanojkovic, Tatjana P ^b   Kovala Demertzi, Dimitra ^a   Primikyri, Alexandra ^a   Garcia Santos, Isabel ^c   Castineiras, Alfonso ^c   Juranic, Zorica ^b   Demertzis, Mavroudis A ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Biological evaluation; Complexes; Crystal structure; In vitro antitumor activity; Thiosemicarbazone; Zn(II)

Indexed keywords

2 ACETYLPYRIDINE N4 1 (4 FLUOROPHENYL)PIPERAZINYL THIOSEMICARBAZONE; ANTINEOPLASTIC AGENT; BIS[2 ACETYLPYRIDINE N4 1 (4 FLUOROPHENYL)PIPERAZINYL THIOSEMICARBAZONATO]ZINC COMPLEX; BIS[MU ACETATO[2 ACETYLPYRIDINE N4 1 (4 FLUOROPHENYL)PIPERAZINYL THIOSEMICARBAZONATO]]ZINC COMPLEX; CISPLATIN; UNCLASSIFIED DRUG; ZINC COMPLEX;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; SPECTRUM ANALYSIS; THIOSEMICARBAZONES; ZINC;

EID: 77049103056     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.12.021     Document Type: Article

References (31)

1. Finch R.A., Liu M.-C., Grill S.P., Rose W.C., Loomis R., Vasquez K.M., Cheng Y.-C., Sartorelli A.C. Biochem. Pharm. 2000, 59:983-991. and references therein.
2. Liberta A.E., West D.X. Biometals 1992, 5:121-126.
3. Beraldo H., Gambino D. Mini Rev. Med. Chem. 2004, 4:159-165.
4. Gomez Quiroga A., Navarro Ranninger C. Coord. Chem. Rev. 2004, 248:119-133.
5. Halder S., Peng S-M., Lee G-H., Chatterjee T., Mukherjee A., Dutta S., Sanyald U., Bhattacharya S. New J. Chem. 2008, 32:105-114.
6. Belicchi-Ferrari M., Bisceglie F., Casoli C., Durot S., Morgenstern-Badara I., Pelosi G., Pilotti E., Pinelli S., Tarasconi P. J. Med. Chem. 2005, 48:1671-1675.
7. Walkup G.K., Burdette S.C., Lippard S.J., Tsien R.Y. J. Am. Chem. Soc. 2000, 122/23:5644-5645.
8. Hellmich H.L., Frederickson C.J., DeWitt D.S., Saban R., Parsley M.O., Stephenson R., Velasco M., Uchida T., Shimamura M., Prough D.S. Neurosci. Lett. 2004, 355/3:221-225.
9. Casas J.S., García-Tasende M.S., Sordo J. Coord. Chem. Rev. 2000, 209:197-261.
10. Chikaraishi Kasuga N., Sekino K., Ishikawa M., Honda A., Yokoyama M., Nakano S., Shimada N., Koumo C., Nomiya K. J. Inorg. Biochem. 2003, 96:298-310.
11. Kovala-Demertzi D., Alexandratos A., Papageorgiou A., Nath Yadav P., Dalezis P., Demertzis M.A. Polyhedron 2008, 27:2731-2738.
12. Kovala-Demertzi D., Nath Yadav P., Wiecek J., Skoulika S., Varadinova T., Demertzis M.A. J. Inorg. Biochem. 2006, 100/9:1558-1567.
13. Scovill J.P., Klayman D.L., Franchino C.F. J. Med. Chem. 1982, 25:1261-1264.
14. Bruker, APEX2 Software, Bruker AXS Inc., V2.0-1, Madison, Wisconsin, USA, 2005.
15. Sheldrick G.M. SADABS, Program for Empirical Absorption Correction of Area Detector Data 1997, University of Goettingen, Germany.
16. Sheldrick G.M. Acta Crystallogr. 1990, A46:467-473.
17. G.M. Sheldrick, SHELXL-97, Program for the Refinement of Crystal Structures, University of Goettingen, Germany, 1997.
18. Wilson A.J.C. International Tables for Crystallography 1995, vol. C. Kluwer Academic Publishers, Dordrecht, The Netherlands.
19. A.L. Spek, PLATON, A Multipurpose Crystallographic Tool, Utrecht University, Utrecht, The Netherlands, 2003.
20. Mosmann T. J. Immunol. Methods 1983, 65:55-63.
21. Ohno M., Abe T. J. Immunol. Methods 1991, 145:199-203.
22. Clothier R.H. Methods Mol. Biol. 1995, 43:109-118.
23. Kovala-Demertzi D., Nath Yadav P., Demertzis M.A., Coluccia M. J. Inorg. Biochem. 2000, 78/4:347-354.
24. Kovala-Demertzi D., Demertzis M.A., Miller J.R., Papadopoulou C., Dodorou C., Filousis G. J. Inorg. Biochem. 2001, 86:555-563.
25. West D.X., Bain G.A., Butcher R.J., Jasinski J.P., Li Y., Pozdniakiv R.Y., Valdes-Marti{dotless}nez J., Toscano R.A., Hernandez-Ortega S. Polyhedron 1996, 15:665-674.
26. Bermejo E., Castineiras A., Garci{dotless}a-Santos Isabel, West D.X. Z. Anorg. Allg. Chem. 2004, 630:1096-1109.
27. Kovala-Demertzi D., Kourkoumelis N., Demertzis M.A., Miller J.R., Frampton C.S., Swearingen J.K., West D.X. Eur. J. Inorg. Chem. 2000, 727-734.
28. Addison A., Nageswara R.T., Reedijk J., Van Rijn J., Verschoor G.C. J. Chem. Soc. Dalton Trans. 1984, 1349-1356.
29. Kovala-Demertzi D., Boccarelli A., Demertzis M.A., Coluccia M. Chemotherapy 2007, 53:148-152.
30. Shao J., Zhou B., Chu B., Yen Y. Curr. Cancer Drug Targets 2006, 6:409-431.
31. Mueller S., Schittenhelm M., Honecker F., Malenke E., Lauber K., Wesselborg S., Hartmann J.T., Bokemeyer C., Mayer F. Int. J. Oncol. 2006, 29:471-479.