Psychotropic drug use among icelandic children: A nationwide population-based study

Journal of Child and Adolescent Psychopharmacology

Volumn 19, Issue 6, 2009, Pages 757-764

  Zoëga, Helga ^a,c   Baldursson, Gísli ^b   Hrafnkelsson, Birgir ^a   Almarsdóttir, Anna Birna ^a   Valdimarsdóttir, Unnur ^a   Halldórsson, Matthías ^c  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c Diractorate of Health in Iceland ^*  (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; ARIPIPRAZOLE; ATOMOXETINE; CENTRAL STIMULANT AGENT; FLUOXETINE; HYPNOTIC SEDATIVE AGENT; MELATONIN; METHYLPHENIDATE; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT; QUETIAPINE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADOLESCENT; ARTICLE; CHILD; DRUG USE; FEMALE; GROUPS BY AGE; HUMAN; ICELAND; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL SPECIALIST; OFF LABEL DRUG USE; PRESCHOOL CHILD; PRESCRIPTION; PREVALENCE; SCHOOL CHILD; SEX DIFFERENCE;

ADOLESCENT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; ICELAND; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; MEDICINE; MENTAL DISORDERS; OFF-LABEL USE; PHYSICIAN'S PRACTICE PATTERNS; POPULATION SURVEILLANCE; PREVALENCE; PSYCHOTROPIC DRUGS; SEX FACTORS;

EID: 77049095146     PISSN: 10445463     EISSN: None     Source Type: Journal    
DOI: 10.1089/cap.2009.0003     Document Type: Article

References (49)

1. Asheim H, Nilsen KB, Johansen K, Furu K: [Prescribing of stimulants for ADHD in Nordland County]. Tidsskr Nor Laegeforen 127:2360-2362, 2007.
2. Baldursson G, Magnusson P, Gudmundsson OO: [Medication use and treatment characteristics of children referred to the outpatient ADHD-clinic at the Department of Child and Adolescent Psychiatry, the National University Hospital.]. Laeknabladid 86:337-342, 2000.
3. Bramness JG, Engeland A, Furu K: [Use of antidepressants among children and adolescents-did the warnings lead to fewer prescriptions?]. Tidsskr Nor Laegeforen 127:2653-2655, 2007.
4. Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, Ren L, Brent DA: Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: A meta-analysis of randomized controlled trials. JAMA 297:1683-1696, 2007.
5. Castle L, Aubert RE, Verbrugge RR, Khalid M, Epstein RS: Trends in medication treatment for ADHD. J Atten Disord 10:335-342, 2007.
6. Clavenna A, Rossi E, Derosa M, Bonati M: Use of psychotropic medications in Italian children and adolescents. Eur J Pediatr 166:339-347, 2007.
7. Danish Medicines Agency. Statistik for lægemidler og lægemiddelgrupper 2003-2007 [database on the Internet] 2008. Available at: http://www.medstat.dk/MedStatDataViewer.php/. Accessed October 20, 2008.
8. Dean AJ, Hendy A, McGuire T: Antidepressants in children and adolescents- changes in utilisation after safety warnings. Pharmacoepidemiol Drug Saf 16:10s48-1053, 2007.
9. Directorate of Health Iceland: Dreifibréf Landlæ knisembættisins nr. 9/2004: Notkun sérhæf0n ra serótónín endurupptöku hemla (SSRI) vi0n •unglyndi hjá börnum og unglingum. June 29, 2004. Available at: http://landlaeknir.is/?PageID=234/. Accessed on November 12, 2008.
10. Faber A, de Jong-van den Berg LT, van den Berg PB, Tobi H: Psychotropic co-medication among stimulant-treated children in The Netherlands. J Child Adolesc Psychopharmacol 15:38-43, 2005.
11. Fegert JM, Kolch M, Zito JM, Glaeske G, Janhsen K: Antidepressant use in children and adolescents in Germany. J Child Adolesc Psychopharmacol 16:197-206, 2006.
12. Gibbons RD, Brown CH, Hur K, Marcus SM, Bhaumik DK, Erkens JA, Herings RM, Mann JJ: Early evidence on the effects of regulators' suicidality warnings on SSRI prescriptions and suicide in children and adolescents. Am J Psychiatry 164:1356-1363, 2007.
13. Gudmundsson O, Skarphedinss G, Saemundsen E, Baldursson G, Lauth B, Magnusson P: Prevalence of psychiatric disorders of 5 year olds in Iceland: A pilot study. Poster presented at the XIII ESCAP Congress, Florence, August 25-29, 2007.
14. Hazell P, O'Connell D, Heathcote D, Robertson J, Henry D: Efficacy of tricyclic drugs in treating child and adolescent depression: A meta-analysis. BMJ 310:897-901, 1995.
15. Hazell P, O'Connell D, Heathcote D, Henry D: Tricyclic drugs for depression in children and adolescents. Cochrane Database Syst Rev (2):CD002317, 2002.
16. Iceland Medicines Controls Agency. Summary of Product Characteristics (SPC). Available at: http://www.imca.is/Licences- for-Medicinal-Products/ Medicinal-Product-Information-(SPC)/. Accessed July-November, 2008.
17. Iceland Social Insurance: Kostnadnur TR 2007: ö rvandi lyf, lyf notudn vidn ADHD og lyf sem efla heilastarfsemi. 2008. Available at: http://www.tr.is/heilsa-og-sjukdomar/lyf/utgafuefni/. Accessed on October 19, 2008.
18. Jureidini JN, Doecke CJ, Mansfield PR, Haby MM, Menkes DB, Tonkin AL: Efficacy and safety of antidepressants for children and adolescents. BMJ 328:879-883, 2004.
19. Lehmann EL, Romano JP: Testing Statistical Hypotheses, 3rd ed. New York: Wiley, 2005.
20. Martin A, Leslie D: Trends in psychotropic medication costs for children and adolescents, 1997-2000. Arch Pediatr Adolesc Med 157:997-1004, 2003.
21. Murray ML, Thompson M, Santosh PJ, Wong IC: Effects of the Committee on Safety of Medicines advice on antidepressant prescribing to children and adolescents in the UK. Drug Saf 28:1151-1157, 2005.
22. Nemeroff CB, Kalali A, Keller MB, Charney DS, Lenderts SE, Cascade EF, Stephenson H, Schatzberg AF: Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Arch Gen Psychiatry 64:466-472, 2007.
23. Norwegian Institute of Public Health. Norwegian Prescription Database [database on the Internet] 2008. Available at http://www. norpd.no/. Accessed October 20 2008.
24. Olfson M, Marcus SC, Weissman MM, Jensen PS: National trends in the use of psychotropic medications by children. J Am Acad Child Adolesc Psychiatry 41:514-521, 2002. (Pubitemid 38338129)
25. Olfson M, Blanco C, Liu L, Moreno C, Laje G: National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Arch Gen Psychiatry 63:679-685, 2006.
26. Olfson M, Marcus SC, Druss BG: Effects of Food and Drug Administration warnings on antidepressant use in a national sample. Arch Gen Psychiatry 65:94-101, 2008.
27. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA: The worldwide prevalence of ADHD: A systematic review and metaregression analysis. Am J Psychiatry 164:942-948, 2007.
28. Ramchandani P: Treatment of major depressive disorder in children and adolescents. BMJ 328:3-4, 2004.
29. Rani F, Murray ML, Byrne PJ, Wong IC: Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom. Pediatrics 121:1002-1009, 2008.
30. Scheffler RM, Hinshaw SP, Modrek S, Levine P: The global market for ADHD medications. Health Aff (Millwood) 26:450-457, 2007.
31. Schirm E, Tobi H, Zito JM, de Jong-van den Berg LT: Psychotropic medication in children: A study from the Netherlands. Pediatrics 108:E25, 2001.
32. Schirm E, Tobi H, de Jong-van den Berg LT: Risk factors for unlicensed and off-label drug use in children outside the hospital. Pediatrics 111:291-295, 2003.
33. Sevilla-Dedieu C, Kovess-Masfety V: Psychotropic medication use in children and adolescents: A study from France. J Child Adolesc Psychopharmacol 18:281-289, 2008.
34. Simon G: Antidepressants and suicide. BMJ 336:515-516, 2008.
35. Statistics Iceland: Population by age and sex 1841-2007. 2008. Available at: http://www.statice.is/Statistics/Population/Overview/. Accessed July 15, 2008.
36. Ufer M, Rane A, Karlsson A, Kimland E, Bergman U: Widespread off-label prescribing of topical but not systemic drugs for 350,000 paediatric outpatients in Stockholm Eur J Clin Pharmacol 58:779-783, 2003.
37. U.S. Food and Drug Administration: Public Health Advisory, Reports of Suicidality in Pediatric Patients being Treated with Antidepressant Medications for Major Depressive Disorder. October 27, 2003. Available at http://www.fda.gov/cder/drug/advisory/mdd. htm/. Accessed November 18, 2008.
38. Vitiello B: Research in child and adolescent psychopharmacology: Recent accomplishments and new challenges. Psychopharmacology (Berl) 191:5-13, 2007.
39. Vitiello B, Swedo S: Antidepressant medications in children. N Engl J Med 350:1489-1491, 2004.
40. Vitiello B, Zuvekas SH, Norquist GS: National estimates of antidepressant medication use among U.S. children, 1997-2002. J Am Acad Child Adolesc Psychiatry 45:271-279, 2006.
41. Volkers AC, Heerdink ER, van Dijk L: Antidepressant use and off-label prescribing in children and adolescents in Dutch general practice (2001-2005). Pharmacoepidemiol Drug Saf 16:1054-1062, 2007.
42. Wheeler BW, Gunnell D, Metcalfe C, Stephens P, Martin RM: The population impact on incidence of suicide and non-fatal self harm of regulatory action against the use of selective serotonin reuptake inhibitors in under 18s in the United Kingdom: Ecological study. BMJ 336:542-545, 2008.
43. Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E: Selective serotonin reuptake inhibitors in childhood depression: Systematic review of published versus unpublished data. Lancet 363:1341-1345, 2004.
44. World Health Organization. WHO Collaborating Centre for Drug Statistics Methodology: ATC/DDD Index. Available at: http:// www.whocc.no/atcddd/. Accessed May-November, 2008.
45. Zito JM, Safer DJ, dosReis S, Magder LS, Riddle MA: Methylphenidate patterns among Medicaid youths. Psychopharmacol Bull 33:143-147, 1997.
46. Zito JM, Safer DJ, DosReis S, Gardner JF, Magder L, Soeken K, Boles M, Lynch F, Riddle MA: Psychotropic practice patterns for youth: A 10-year perspective. Arch Pediatr Adolesc Med 157:17-25, 2003.
47. Zito JM, Safer DJ, Valluri S, Gardner JF, Korelitz JJ, Mattison DR: Psychotherapeutic medication prevalence in Medicaid-insured preschoolers. J Child Adolesc Psychopharmacol 17:195-203, 2007.
48. Zoega H, Baldursson G, Halldorsson M: [Use of methylphenidate among children in Iceland 1989-2006]. Laeknabladid 93:825-832, 2007.
49. Zuvekas SH, Vitiello B, Norquist GS: Recent trends in stimulant medication use among U.S. children. Am J Psychiatry 163:579-585, 2006.