Solvent-induced virus inactivation by acidic arginine solution

International Journal of Molecular Medicine

Volumn 25, Issue 3, 2010, Pages 433-437

  Tsujimoto, Kazuko ^a   Uozaki, Misao ^a   Ikeda, Keiko ^a   Yamazaki, Hisashi ^a   Utsunomiya, Hirotoshi ^b   Ichinose, Masao ^a   Koyama, A Hajime ^a   Arakawa, Tsutomu ^c  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b Department of Strategic Surveillance for Functional Food and Comprehensive Traditional Medicine ^*  (Japan)

^c ALLIANCE PROTEIN LABORATORIES   (United States)

Author keywords

Arginine; Herpes simplex virus; Solvent; Temperature; Virus inactivation

Indexed keywords

ACIDIC ARGININE; ARGININE; CITRIC ACID; SODIUM CHLORIDE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HERPES SIMPLEX VIRUS 2; IONIC STRENGTH; MODEL; NONHUMAN; PH; PRIORITY JOURNAL; SOLVENT EFFECT; SOLVENT INDUCED VIRUS INACTIVATION; TEMPERATURE SENSITIVITY; VIRUS INACTIVATION; VIRUS INFECTIVITY; VIRUS PARTICLE;

ANIMALS; ANTIVIRAL AGENTS; ARGININE; CERCOPITHECUS AETHIOPS; HERPESVIRUS 2, HUMAN; HYDROGEN-ION CONCENTRATION; SOLUTIONS; SOLVENTS; TEMPERATURE; VERO CELLS; VIRUS INACTIVATION;

EID: 76949100418     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000362     Document Type: Article

References (21)

1. Preuss T, Kamstrup S, Kyvsgaard NC, Nansen P, Miller A and Lei JC: Comparison of two different methods for inactivation of viruses I serum. Clin Diagn Lab Immunol 4: 504-508, 1997.
2. Brorson K and Norling L: Current and future approaches to ensure the viral safety of biopharmaceuticals. Dev Biol 118: 17-29, 2004.
3. Lee JC and Timasheff SN: Partial specific volumes and interactions with solvent components of proteins in guanidine hydrochloride. Biochemistry 13: 257-265, 1974.
4. Kita Y, Arakawa T, Lin TY and Timasheff SN: Contribution of the surface free energy perturbation to protein-solvent interactions. Biochemistry 33: 15178-15189, 1994.
5. Gekko K and Timasheff SN: Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures. Biochemistry 20: 4667-4676, 1981.
6. Schellman JA: Selective binding and solvent denaturation. Biopolymers 26: 549-559, 1987.
7. Arakawa T, Ejima D, Tsumoto K, Obeyama N, Tanaka Y, Kita Y and Timasheff SN: Suppression of protein interactions by arginine: a proposed mechanism of the arginine effects. Biophys Chem 127: 1-8, 2007.
8. Arakawa T, Kita Y and Timasheff SN: Protein precipitation and denaturation by dimethyl sulfoxide. Biophys Chem 131: 62-70, 2007.
9. Yamasaki H, Tsujimoto K, Koyama AH, Ejima D and Arakawa T: Arginine facilitates inactivation of enveloped viruses. J Pharm Sci 97: 3067-3073, 2008.
10. Katsuyama Y, Yamasaki H, Tsujimoto K, Koyama AH, Ejima D and Arakawa T: Butyroyl-arginine as a potent virus inactivation agent. Int J Pharm 361: 92-98, 2008.
11. Utsunomiya H, Ichinose M, Tsujimoto K, Katsuyama Y, Yamasaki H, Koyama AH, Ejima D and Arakawa T: Co-operative thermal inactivation of herpes simplex virus and influenza virus by arginine and NaCl. Int J Pharm 366: 99-102, 2009.
12. Arakawa T, Kita Y and Koyama AH: Synergistic virus inactivation effects of arginine. Biotech J 4: 174-178, 2009.
13. Keller MJ, Tuyama A, Carlucci MJ and Herold BC: Topical microbicides for the prevention of genital herpes infection. J Antimicrob Chemother 55: 420-423, 2005.
14. Koyama AH and Uchida T: The effect of ammonium chloride on the multiplication of herpes simplex virus type 1 in Vero cells. Virus Res 13: 271-282, 1989.
15. Tsumoto K, Ejima D, Kita Y and Arakawa T: Review: why is arginine effective in suppressing aggregation? Protein Pept Lett 12: 613-619, 2005.
16. Arakawa T and Tsumoto K: The effects of argnine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation. Biochem Biophys Res Commun 304: 148-152, 2003.
17. Hegardt FG and Pië A: Sodium citrate salting-out of the human blood serum proteins. Rev Esp Fisiol 24: 161-168, 1968.
18. Arakawa T and Timasheff SN: Preferential interactions of proteins with salts in concentrated solutions. Biochemistry 21: 6545-6552, 1982.
19. Kaushik JK and Bhat R: A mechanistic analysis of the increase in the thermal stability of proteins in aqueous carboxylic acid salt solutions. Protein Sci 8: 222-233, 1999.
20. Hayashi K, Hayashi T and Tomoda A: Phenoxazine derivatives inactivate human cytomegalovirus, herpes simplex virus-1, and herpes simplex virus-2 in vitro. J Pharmacol Sci 106: 369-375, 2008.
21. Kratz JM, Andrighetti-Fröhner CR, Leal PC, Nunes RJ, Yunes RA, Trybala E, Bergström T, Barardi CRM and Simöes CMO: Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate. Biol Pharm Bull 31: 903-907, 2008.