Tailored total lymphoid irradiation in heart transplant patients: 10-years experience of one center

Radiation Oncology

Volumn 5, Issue 1, 2010, Pages

  Ghadjar, Pirus ^a   Joos, Daniela ^a   Martinelli, Michele ^b   Hullin, Roger ^b   Zwahlen, Marcel ^c,d   Lössl, Kristina ^a   Carrel, Thierry ^b   Aebersold, Daniel M ^a   Mohacsi, Paul ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b BERN UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d NONE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; COBALT 60; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; BONE MARROW SUPPRESSION; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; EPIGASTRIC PAIN; FATIGUE; FEMALE; HEART GRAFT; HEART MUSCLE BIOPSY; HERPES ZOSTER; HUMAN; HUMAN TISSUE; LEUKOCYTE COUNT; LEUKOPENIA; LONG TERM CARE; LYMPH NODE IRRADIATION; LYMPHOPROLIFERATIVE DISEASE; MAINTENANCE THERAPY; MALE; OUTCOME ASSESSMENT; PATIENT SAFETY; PNEUMOCYSTIS PNEUMONIA; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RADIATION SAFETY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; UROSEPSIS; FOLLOW UP; GRAFT REJECTION; HEART TRANSPLANTATION; MIDDLE AGED; RADIOTHERAPY; RETROSPECTIVE STUDY; TREATMENT OUTCOME;

ADULT; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; LYMPHATIC IRRADIATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 76949085730     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-5-3     Document Type: Article

References (25)

1. Kirklin JK, Naftel DC, McGiffin DC, McVay RF, Blackstone EH, Karp RB. Analysis of morbid events and risk factors for death after cardiac transplantation. J Am Coll Cardiol 1988, 11:917-924.
2. Lim TS, O Driscoll G, Freund J, Peterson V, Hayes H, Heywood J. Short-course of total lymphoid irradiation for refractory cardiac transplantation rejection. J Heart Lung Transplant 2007, 26:1249-54. 10.1016/j.healun.2007.09.002, 18096475.
3. Frist W, Winterland A, Gerhardt EB, Merrill WH, Atkinson JB, Eastburn TE, Stewart JR, Eisert DR. Total lymphoid irradiation in heart transplantation: adjunctive treatment for recurrent rejection. Ann Thorac Surg 1989, 48:863-4.
4. Macoviak JA, Darrell J, Simmons J, et al. Low dose total lymphoid irradiation for recalcitrant myocardial rejection. J Heart Lung Transplant 1990, 9:76.
5. Hunt SA, Strober S, Hoppe RT, Strinson EB. Total lymphoid irradiation for treatment of intractable cardiac allograft rejection. J Heart Lung Transplant 1991, 10:211-6.
6. Salter MM, Kirklin JK, Bourge RC, Naftel DC. Total lymphoid irradiation in the treatment of early or recurrent heart rejection. J Heart Lung Transplant 1992, 11:902-12.
7. Evans MA, Schomberg PJ, Rodeheffer RJ, Katzmann JA, Schnell WA, Tazelaar HD, McGregor CG, Edwards BS. Total lymphoid irradiation: a novel and successful therapy for resistant cardiac allograft rejection. Mayo Clin Poc 1992, 67:785-90.
8. Kirklin JK, George JF, McGiffin DC, Naftel DC, Salter MM, Bourge RC. Total lymphoid irradiation: is there a role in pediatric heart transplantation?. J Heart Lung Transplant 1993, 12:S293-300.
9. Salter SP, Salter MM, Kirklin JK, Bourge RC, Naftel DC. Total lymphoid irradiation in the treatment of early or recurrent heart rejection. Int J Radiat Oncol Biol Phys 1995, 33:83-8.
10. Keogh A, Morgan G, MacDonald P, Spratt P, Mundy J, McCosker C. Clinical heart transplantation. Total lymphoid irradiation for resistant rejection after heart transplantation: only moderate success medium-term. J Heart Lung Tranplant 1996, 15:231-3.
11. Madden BP, Backhouse L, McClosky D, Reynolds L, Tait D, Murday A. Total lymphoid irradiation as rescue therapy after heart transplantation. J Heart Lung Transplant 1996, 15:234-8.
12. Wolden SL, Tate DL, Hunt SA, Strober S, Hoppe R. Long term results of total lymphoid irradiation in the treatment of cardiac allograft rejection. Int J Radiat Oncol Biol Phys 1997, 39:953-60.
13. Ross HJ, Gullestad L, Pak J, Slauson S, Valantine HA, Hunt SA. Methotrexate or total lymphoid radiation for treatment of persistent or recurrent allograft cellular rejection: a comparative study. J Heart Lung Transplant 1997, 16:179-89.
14. Trachiotis GD, Johnston TS, Vega JD, Crocker IR, Chesnut N, Lutz JF, Smith AL, Kanter KR. Single field total lymphoid irradiation in the treatment of refractory rejection after heart transplantation. J Heart Lung Transplant 1998, 17:1045-8.
15. Madden BP, Barros J, Backhouse L, Stamenkovic S, Tait D, Murday A. Intermediate term results of total lymphoid irradiation for the treatment of non-specific graft dysfunction after heart transplantation. Eur J Cardiothorac Surg 1999, 15:663-6. 10.1016/S1010-7940(99)00042-1, 10386414.
16. Keogh AM, Arnold RH, MacDonald PS, Hawkins RC, Morgan GW, Spratt PM. A randomized trial of tacrolimus versus total lymphoid irradiation for the control of repetitive rejection after cardiac transplantation. J Heart Lung Transplant 2001, 20:1331-4. 10.1016/S1053-2498(01)00329-1, 11744418.
17. Chin C, Hunt S, Robbins R, Hoppe R, Reitz B, Bernstein D. Long term follow-up after total lymphoid irradiation in pediatric heart transplant recipients. J Heart Lung Transplant 2002, 21:667-73. 10.1016/S1053-2498(01)00772-0, 12057700.
18. Asano M, Gundry SR, Razzouk AJ, del Rio MJ, Thomas M, Chinnock RE, Bailey LL. Total lymphoid irradiation for refractory rejection in pediatric heart transplantation. Ann Thorac Surg 2002, 74:1979-85. 10.1016/S0003-4975(02)04065-1, 12643383.
19. Billingham ME, Cary NR, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A. A working formulation for the standarization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Lung Transplant 1990, 9:587-93.
20. Koestner SC, Kappeler A, Schaffner T, Carrel TP, Nydegger UE, Mohacsi P. Histo-blood group type change of the graft from B to 0 after AB0 mismatched heart transplantation. Lancet 2004, 363:1523-25. 10.1016/S0140-6736(04)16179-5, 15135601.
21. Swinnen LJ, Costanzo-Nordin MR, Fisher SG, O'Sullivan EJ, Johnson MR, Heroux AL, Dizikes GJ, Pifarre R, Fisher RI. Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med 1990, 323:1723-28.
22. Constanzo-Nordin MR, O'Sullivan EJ, Hubbell EA, Zucker MJ, Pifarre R, McManus BM, Winters GL, Scanlon PJ, Robinson JA. Long-term follow-up of heart transplant recipients treated with murine antihuman mature T-cell monoclonal antibody (OKT3): the Loyola experience. J Heart Transplant 1989, 8:288-95.
23. Bourge RC, Kirklin JK, McGriffin DC, et al. Total lymphoid irradiation after cardiac transplantation: is there a risk of late leukaemia [abstract]. J Heart Lung Transpl Program Issue 1998,
24. Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008, 5:659-68.
25. Murphy JD, Spalding AC, Somnay YR, Markwart S, Ray ME, Hamstra DA. Inhibition of mTOR radiosensitizes soft tissue sarcoma and tumor vasculature. Clin Cancer Res 2009, 15:589-96. 10.1158/1078-0432.CCR-08-1019, 19147764.