Deep Brain Stimulation for Intractable Obsessive Compulsive Disorder: Pilot Study Using a Blinded, Staggered-Onset Design

Biological Psychiatry

Volumn 67, Issue 6, 2010, Pages 535-542

  Goodman, Wayne K ^a   Foote, Kelly D ^b   Greenberg, Benjamin D ^d   Ricciuti, Nikki ^b   Bauer, Russell ^c   Ward, Herbert ^b   Shapira, Nathan A ^b   Wu, Sam S ^b   Hill, Candy L ^b   Rasmussen, Stephen A ^d   Okun, Michael S ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Arousal; deep brain stimulation; major depression; obsessive compulsive disorder; ventral capsule; ventral striatum

Indexed keywords

ADULT; ARTICLE; BRAIN DEPTH STIMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORPUS STRIATUM; DEPRESSION; DISEASE SEVERITY; ELECTRODE; FEMALE; HUMAN; MALE; NEUROLOGIC EXAMINATION; OBSESSIVE COMPULSIVE DISORDER; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SHAM PROCEDURE; TREATMENT RESPONSE; YALE BROWN OBSESSIVE COMPULSIVE SCALE;

ANALYSIS OF VARIANCE; DEEP BRAIN STIMULATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERNAL CAPSULE; LIMBIC SYSTEM; MALE; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 76849110186     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.11.028     Document Type: Article

References (35)

1. Goodman W.K., Ward H.E., Kablinger A.S., and Murphy T.K. Biological approaches to treatment-resistant obsessive compulsive disorder. In: Goodman W.K., Rudorfer M.V., and Maser J. (Eds). Obsessive Compulsive Disorder: Contemporary Issues in Treatment (2000), Lawrence Erlbaum Associates, New York
2. Baer L., Rauch S.L., Ballantine Jr. H.T., Martuza R., Cosgrove R., Cassem E., et al. Cingulotomy for intractable obsessive-compulsive disorder. Prospective long-term follow-up of 18 patients. Arch Gen Psychiatry 52 (1995) 384-392
3. Goodman W.K., and Insel T.R. Deep brain stimulation in psychiatry: Concentrating on the road ahead. Biol Psychiatry 65 (2009) 263-266
4. Rezai A.R., Machado A.G., Deogaonkar M., Azmi H., Kubu C., and Boulis N.M. Surgery for movement disorders. Neurosurgery 62 suppl 2 (2008) 809-838
5. Nuttin B., Cosyns P., Demeulemeester H., Gybels J., and Meyerson B. Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder. Lancet 354 (1999) 1526
6. Greenberg B.D., Price L.H., Rauch S.L., Friehs G., Noren G., Malone D., et al. Neurosurgery for intractable obsessive-compulsive disorder and depression: Critical issues. Neurosurg Clin North Am 14 (2003) 199-212
7. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM IV Axis I Disorders-Clinician Version (SCID-CV) (1997), American Psychiatric Publishing, Washington, DC
8. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Part II. Validity. Arch Gen Psychiatry 46 (1989) 1012-1016
9. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown obsessive Compulsive Scale (Y-BOCS). Part I. Development, use, and reliability. Arch Gen Psychiatry 46 (1989) 1006-1011
10. Greenberg B.D., Gabriels L.A., Malone Jr. D.A., Rezai A.R., Friehs G.M., Okun M.S., et al. Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: Worldwide experience. [published online ahead of print May 20]. Mol Psychiatry (2008)
11. Okun M.S., Mann G., Foote K.D., Shapira N.A., Bowers D., Springer U., et al. Deep brain stimulation in the internal capsule and nucleus accumbens region: Responses observed during active and sham programming. J Neurol Neurosurg Psychiatry 78 (2007) 310-314
12. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
13. Guy W. ECDEU Assessment Manual for Psychopharmacology (1976), US Department of Health, Education, and Welfare, Rockville, MD DHEW Publication (ADM) 76-338
14. McNair D.M., Lorr M., and Droppleman L.F. Profile of Mood States (1971), Multi-Health Systems, North Tonawanda, NY
15. Ware J.E., Snow K.K., Kosinski M., and Gandek B. SF-36 Health Survey Manual and Interpretation Guide (1993), New England Medical Center, The Health Institute, Boston
16. Heaton R.K., Chelune G.J., Talley J.L., Kay C.G., and Curtis G. Wisconsin Card Sorting Test Manual (1993), Psychological Resources, Odessa, FL
17. Ortet G., Ibáñez M.I., Llerena A., and Torrubia R. The underlying traits of the Karolinska Scales of Personality (KSP). Eur J Psychol Assess 18 (2002) 139-148
18. Benton A.L., Hamsher K., and Sivan A.B. Multilingual Aphasia Examination. 3rd ed. (1994), AJA Associates, Iowa City
19. Shapiro A.M., Benedict R.H., Schretlen D., and Brandt J. Construct and concurrent validity of the Hopkins Verbal Learning Test-Revised. Clin Neuropsychol 13 (1999) 348-358
20. Matthews C.G., and Klöve H. Instruction Manual for the Adult Neuropsychological Test Battery (1964), University of Wisconsin, Madison, WI
21. Anderson P.A., Anderson V.B., and Lajoie G.A. The tower of London test: Validation and standardization for pediatric populations. Clin Neuropsychol 10 (1996) 54-65
22. Wechsler D. WAIS-III: Administration and Scoring Manual: Wechsler Adult Intelligence Scale. 3rd ed. (1997), Psychological Corporation, San Antonio, TX
23. Shapira N.A., Okun M.S., Wint D., Foote K.D., Byars J.A., Bowers D., et al. Panic and fear induced by deep brain stimulation. J Neurol Neurosurg Psychiatry 77 (2006) 410-412
24. Okun M.S., Bowers D., Springer U., Shapira N.A., Malone D., Rezai A.R., et al. What's in a "smile?". Intra-operative observations of contralateral smiles induced by deep brain stimulation. Neurocase 10 (2004) 271-279
25. Greenberg B.D., Malone D.A., Friehs G.M., Rezai A.R., Kubu C.S., Malloy P.F., et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 31 (2006) 2384-2393
26. Abelson J.L., Curtis G.C., Sagher O., Albucher R.C., Harrigan M., Taylor S.F., et al. Deep brain stimulation for refractory obsessive-compulsive disorder. Biol Psychiatry 57 (2005) 510-516
27. Nuttin B.J., Gabriels L.A., Cosyns P.R., Meyerson B.A., Andreewitch S., Sunaert S.G., et al. Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 52 (2003) 1263-1272 discussion:1272-1274
28. Mallet L., Polosan M., Jaafari N., Baup N., Welter M.L., Fontaine D., et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med 359 (2008) 2121-2134
29. Khan A., Kolts R.L., Rapaport M.H., Krishnan K.R., Brodhead A.E., and Browns W.A. Magnitude of placebo response and drug-placebo differences across psychiatric disorders. Psychol Med 35 (2005) 743-749
30. Malone Jr. D.A., Dougherty D.D., Rezai A.R., Carpenter L.L., Friehs G.M., Eskandar E.N., et al. Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry 65 (2009) 267-275
31. Schlaepfer T.E., Cohen M.X., Frick C., Kosel M., Brodesser D., Axmacher N., et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology 33 (2008) 368-377
32. Hsu D.T., and Price J.L. Paraventricular thalamic nucleus: Subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys. J Comp Neurol 512 (2009) 825-848
33. Van Der Werf Y.D., Witter M.P., and Groenewegen H.J. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev 39 (2002) 107-140
34. Richardson R.M., Ostrem J.L., and Starr P.A. Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: Location of effective and ineffective leads. Stereotact Funct Neurosurg 87 (2009) 297-303
35. Ellis T.M., Foote K.D., Fernandez H.H., Sudhyadhom A., Rodriguez R.L., Zeilman P., et al. Reoperation for suboptimal outcomes after deep brain stimulation surgery. Neurosurgery 63 (2008) 754-761