Biological implications of thymectomy for myasthenia gravis

Surgery Today

Volumn 40, Issue 2, 2010, Pages 102-107

  Okumura, Meinoshin ^a   Inoue, Masayoshi ^a   Kadota, Yoshihisa ^a   Hayashi, Akio ^a   Tokunaga, Toshiteru ^a   Kusu, Takashi ^a   Sawabata, Noriyoshi ^a   Shiono, Hiroyuki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine receptor; Autoimmune disease; Paraneoplastic autoimmunity; Thymoma; Thymus

Indexed keywords

ANTI MUSCLE SPECIFIC KINASE ANTIBODY; CHOLINERGIC RECEPTOR ANTIBODY; CYCLOSPORIN A; ENZYME ANTIBODY; IMMUNOSUPPRESSIVE AGENT; STEROID; TACROLIMUS; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ARTICLE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; GERMINAL CENTER; HUMAN; KIDNEY DISEASE; MINIMALLY INVASIVE SURGERY; MYASTHENIA GRAVIS; PATHOGENESIS; THYMECTOMY; THYMOMA; TREATMENT PLANNING; TUMOR IMMUNOLOGY;

ADULT; AGE FACTORS; AUTOANTIBODIES; B-LYMPHOCYTES; CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MYASTHENIA GRAVIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC; RECEPTORS, NICOTINIC; T-LYMPHOCYTES; TACROLIMUS; THYMECTOMY; THYMOMA; THYMUS GLAND;

EID: 76849105779     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-009-4134-2     Document Type: Article

References (30)

1. A. Vincent 1980 Immunology of acetylcholine receptors in relation to myasthenia gravis Physiol Rev 60 756 824 1:CAS:528:DyaL3cXks1Oks7o%3D 6248907
2. J. Lindstrom D. Shelton Y. Fujii 1988 Myasthenia gravis Adv Immunol 42 233 284 10.1016/S0065-2776(08)60847-0 1:STN:280:DyaL1c3gslSjtw%3D%3D 3284290
3. A. Vincent N. Willcox M. Hill J. Curnow C. MacLennan D. Beeson 1998 Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis Immunol Rev 164 157 168 10.1111/j.1600-065X.1998.tb01217.x 1:CAS:528:DyaK1cXmvVWgtbc%3D 9795773 (Pubitemid 28438405)
4. A. Blalock M.F. Mason H.J. Morgan S.S. Riven 1939 Myasthenia gravis and tumors of the thymic region-report of a case in which the tumor was removed Ann Surg 110 544 561 10.1097/00000658-193910000-00005 1:STN:280: DC%2BD2srkt1Gnsg%3D%3D 17857470
5. N. Willcox 1993 Myasthenia gravis Curr Opin Immunol 5 910 917 10.1016/0952-7915(93)90105-2 1:CAS:528:DyaK2cXlt1Smug%3D%3D 8297524 (Pubitemid 23347453)
6. A.I. Levinson L.M. Wheatley 1996 The thymus and the pathogenesis of myasthenia gravis Clin Immunol Immunopath 78 1 5 10.1006/clin.1996.0001 1:STN:280:DyaK287ntlylsQ%3D%3D (Pubitemid 26078307)
7. A. Marx A. Schultz A. Wilisch M. Helmreich R. Nenninger H.-K. Müller-Hermelink 1998 Paraneoplastic autoimmunity in thymus tumors Dev Immunol 6 129 140 10.1155/1998/49484 1:STN:280:DyaK1czot1KnsA%3D%3D 9716914
8. A. Masaoka Y. Yamakawa H. Niwa I. Fukai S. Kondo M. Kobayashi, et al. 1996 Extended thymectomy for myasthenia gravis patients: A 20-year review Ann Thorac Surg 62 853 859 10.1016/S0003-4975(96)00376-1 1:STN:280: DyaK28znvVCmtA%3D%3D 8784019 (Pubitemid 26301789)
9. G.S. Gronseth R.J. Barohn 2000 Practice parameter: thymectomy for autoimmune myasthenia gravis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology Neurology 55 7 15 1:STN:280:DC%2BD3czovVOltQ%3D%3D 10891896
10. W. Hoch J. McConville S. Helms J. Newsom-Davis A. Melms A. Vincent 2001 Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies Nat Med 7 365 368 10.1038/85520 1:CAS:528:DC%2BD3MXhvVOktLg%3D 11231638 (Pubitemid 32224355)
11. D.B. Sanders K. El-Salem J.M. Massey J. McConville A. Vincent 2003 Clinical aspects of MuSK antibody positive seronegative MG Neurology 60 1978 1980 1:STN:280:DC%2BD3s3psVCitQ%3D%3D 12821744
12. G.K. Scadding A. Vincent J. Newsom-Davis K. Henry 1981 Acetylcholine receptor antibody synthesis by thymic lymphocytes. Correlation with thymic histology Neurology 31 935 943 1:STN:280:DyaL3M3ntFWktg%3D%3D 6973710
13. Y. Fujii Y. Monden K. Nakahara J. Hashimoto Y. Kawashima 1984 Antibody to acetylcholine receptor in myasthenia gravis: production by lymphocytes from thymus or thymoma Neurology 34 1182 1186 1:STN:280:DyaL2c3ntFajtg%3D%3D 6611521
14. Y. Fujii J. Hashimoto Y. Monden T. Ito K. Nakahara Y. Kawashima 1986 Specific activation of lymphocytes against acetylcholine receptor in the thymus in myasthenia gravis J Immunol 136 887 891 1:STN:280:DyaL28%2FoslansA%3D%3D 2416838
15. G.P. Sims H. Shiono N. Willcox D.I. Scott 2001 Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis J Immunol 167 1935 1944 1:CAS:528: DC%2BD3MXlvFeqtLs%3D 11489973
16. H. Shiono I. Roxanis W. Zhang P. Sims A. Meager L.W. Jacobson, et al. 2003 Scenario for autoimmunization of T and B cells in myasthenia gravis Ann N Y Acad Sci 998 237 256 10.1196/annals.1254.026 1:CAS:528:DC%2BD3sXosFyntrs%3D 14592881 (Pubitemid 37194165)
17. H. Shiono Y. Fujii M. Okumura Y. Takeuchi M. Inoue H. Matsuda 1997 Failure to down-regulate Bcl-2 protein in thymic germinal center B cells in myasthenia gravis Eur J Immunol 27 805 809 10.1002/eji.1830270402 1:CAS:528:DyaK2sXislShsLw%3D 9130628 (Pubitemid 27153645)
18. Y. Fujii M. Hayakawa K. Nakahara 1992 Thymus cells in myasthenia gravis: a two-colour flow cytometric analysis of lymphocytes in the thymus and thymoma J Neurol 239 82 88 10.1007/BF00862978 1:STN:280:DyaK383gt12lsg%3D%3D 1552308
19. M. Giraud R. Taubert C. Vandiedonck X. Ke M. Lévi-Strauss F. Pagani, et al. 2007 An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus Nature 448 934 937 10.1038/nature06066 1:CAS:528:DC%2BD2sXptlWjs7Y%3D 17687331 (Pubitemid 47312776)
20. M. Okumura M. Ohta Y. Takeuchi H. Shiono M. Inoue K. Fukuhara, et al. 2003 The immunologic role of thymectomy in the treatment of myasthenia gravis: Implication of thymus-associated Blymphocyte subset in reduction of the anti-acetylcholine receptor antibody titer J Thorac Cardiovasc Surg 126 1922 1928 10.1016/S0022-5223(03)00938-3 14688707 (Pubitemid 38020753)
21. M.I. Leite P. Ströbel M. Jones K. Micklem R. Moritz R. Gold, et al. 2005 Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG Ann Neurol 57 444 448 10.1002/ana.20386 15732104 (Pubitemid 40343969)
22. A. Hayashi H. Shiono M. Ohta K. Ohta M. Okumur Y. Sawa 2007 Heterogeneity of immunopathological features of AChR/MuSK autoantibody-negative myasthenia gravis J Neuroimmunol 189 163 168 10.1016/j.jneuroim.2007.07.007 1:CAS:528:DC%2BD2sXhtVWitL%2FI 17706794 (Pubitemid 47379436)
23. M. Okumura Y. Fujii H. Shiono M. Inoue M. Minami T. Utsumi, et al. 2008 Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis Gen Thorac Cardiovasc Surg 56 143 150 10.1007/s11748-007-0185-8 18401674
24. C. Buckley D. Douek J. Newsome-Davis A. Vincent N. Willcox 2001 Mature, long-lived CD4+ and CD8+ T cell are generated by thy thymoma in myasthenia gravis Ann Neurol 50 64 72 10.1002/ana.1017 1:STN:280:DC%2BD38%2FitFOgug%3D%3D 11456312 (Pubitemid 32591464)
25. A. Meager A. Vincent J. Newsom-Davis N. Willcox 1997 Spontaneous neutralizing antibodies to interferon-alpha and interleukin-12 in thymoma-associated autoimmune disease Lancet 350 1596 10.1016/S0140-6736(05) 64012-3 1:STN:280:DyaK1c%2FlsFSlsg%3D%3D 9393342
26. H. Shiono Y.L. Wong I. Matthews J.L. Liu W. Zhang G. Sims, et al. 2003 Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor Int Immunol 15 903 913 10.1093/intimm/dxg088 1:CAS:528: DC%2BD3sXlslOjt78%3D 12882828 (Pubitemid 36987288)
27. R.S. Tindall J.A. Rollins J.T. Phillips R.G. Greenlee L. Wells G. Belendiuk 1987 Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis N Engl J Med 316 719 724 1:STN:280:DyaL2s7ksVCltA%3D%3D 3547126
28. A. Nagaishi M. Yukitake Y. Kuroda 2008 Long-term treatment of steroid-dependent myasthenia gravis patients with low-dose tacrolimus Intern Med 47 731 736 10.2169/internalmedicine.47.0513 18421189 (Pubitemid 351936221)
29. M. Hiratsuka A. Iwasaki T. Shirakusa S. Yoneda S. Yamamoto T. Shiraishi, et al. 2006 Role of video-assisted thoracic surgery for the treatment of myasthenia gravis: extended thymectomy by median sternotomy versus the thoracoscopic approach with sternal lifting Int Surg 91 44 51 16706103
30. H. Shiono A. Inoue N. Tomiyama N. Shigemura K. Ideguchi M. Inoue, et al. 2006 Safer video-assisted thoracoscopic thymectomy after location of thymic veins with multidetector computed tomography Surg Endosc 20 1419 1422 10.1007/s00464-005-0659-7 1:STN:280:DC%2BD28rmtlCksw%3D%3D 16736308 (Pubitemid 44451256)