Immunopathology on hepatocyte expression of HBV surface, core, and x antigens in chronic hepatitis B: Clinical and virological correlation

Digestive Diseases and Sciences

Volumn 55, Issue 2, 2010, Pages 446-451

  Chu, Chia Ming ^a   Shyu, Wei Chue ^a   Liaw, Yun Fan ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Chronic hepatitis B; HBcAg; HBsAg; HBV DNA; HBxAg; Hepatitis B virus; Immunopathology

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS X PROTEIN; VIRUS ANTIGEN; HEPATITIS B(E) ANTIGEN; TRANSACTIVATOR PROTEIN; VIRUS DNA;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL NUCLEUS; CYTOPLASM; FEMALE; GENOTYPE; HEPATITIS B; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; LIVER CELL; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; BIOSYNTHESIS; COMPARATIVE STUDY; FOLLOW UP; GENETICS; HEPATITIS B VIRUS; IMMUNOLOGY; METABOLISM; PATHOLOGY; VIROLOGY;

ADULT; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATOCYTES; HUMANS; MALE; TRANS-ACTIVATORS;

EID: 76849094818     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-0895-0     Document Type: Article

References (23)

1. Bianchi L, Gudat F. Histo-and immunopathology of viral hepatitis. In: Deinhardt F, Deinhardt J, eds. Viral hepatitis: Laboratory and clinical science. New York: Marcel Dekker; 1983:335-382.
2. Goodman Z. Histopathology of hepatitis B virus infection. In: Lai CL, Locarnini S, eds. Hepatitis B virus. London: International Medical Press; 2002:131-143.
3. CM Chu YF Liaw 1987 Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection Gastroenterology 92 220 225 1:STN:280:DyaL2s%2FlsFWjsQ%3D%3D 3536652
4. CM Chu YF Liaw 1990 Intrahepatic expression of HBcAg in chronic HBV hepatitis: Lessons from molecular biology Hepatology 12 1443 1445 10.1002/hep.1840120630 1:STN:280:DyaK3M%2FnvVOrtA%3D%3D 2258161
5. CM Chu CT Yeh IS Sheen YF Liaw 1995 Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B Gastroenterology 109 1926 1932 10.1016/0016-5085(95)90760-2 1:STN:280: DyaK28%2Fos1yjsw%3D%3D 7498658
6. CM Chu CT Yeh RN Chien IS Sheen YF Liaw 1997 The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflect the level of viral replication in chronic hepatitis B virus infection J Clin Microbiol 35 102 105 1:CAS:528:DyaK2sXktVKlsw%3D%3D 8968888
7. HC Hsu IJ Su MY Lai DS Chen MH Chang JL Sung 1987 Biologic and prognostic significance of hepatocyte hepatitis B core antigen expression in the course of chronic hepatitis B virus infection J Hepatol 5 45 50 10.1016/S0168-8278(87) 80060-0 1:STN:280:DyaL1c%2FgvV2ltQ%3D%3D 3655309
8. CW Kim SK Yoon ES Jung CK Jung JW Jang MS Kim SY Lee SH Bae JY Choi SW Choi NI Han CD Lee 2007 Correlation of hepatitis B core antigen and beta-catenin expression on hepatocytes in chronic hepatitis B virus infection: Relevance to the severity of liver damage and viral replication J Gastroenterol Hepatol 22 1534 1542 10.1111/j.1440-1746.2007.04849.x 1:CAS:528:DC%2BD2sXhtFGgtLfF 17559383 (Pubitemid 47274577)
9. E Serinoz M Varli E Erden K Cinar A Kansu O Uzunalimoglu C Yurdaydin H Bozkaya 2003 Nuclear localization of hepatitis B core antigen and its relations to liver injury, hepatocyte proliferation, and viral load J Clin Gastroenterol 36 269 272 10.1097/00004836-200303000-00016 1:CAS:528:DC%2BD3sXht1KhsrY%3D 12590241 (Pubitemid 36232641)
10. CM Chu YF Liaw 2005 Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: A longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline J Hepatol 43 411 417 10.1016/j.jhep.2005.03.018 1:CAS:528:DC%2BD2MXntVCkurk%3D 16006001 (Pubitemid 41111421)
11. K Ishak A Baptista L Bianchi F Callea J De Groote F Gudat h Denk V Desmet G Korb RN MacSween, et al. 1995 Histological grading and staging of chronic hepatitis J Hepatol 22 696 699 10.1016/0168-8278(95)80226-6 1:STN:280: DyaK28%2FjsFWntw%3D%3D 7560864
12. CJ Chu M Hussain AS Lok 2002 Quantitative serum HBV DNA levels during different stages of chronic hepatitis B infection Hepatology 36 1408 1415 1:CAS:528:DC%2BD38Xps1ylurs%3D 12447866
13. R Ozaras F Tabak V Tahan R Ozturk H Akin A Mert H Senturk 2008 Correlation of quantitative assay of HBsAg and HBV DNA levels during chronic HBV treatment Dig Dis Sci 53 2995 2998 10.1007/s10620-008-0263-5 1:CAS:528:DC%2BD1cXht1ChsbnP 18409002
14. Y Haruna N Hayashi K Katayama N Yuki A Kasahara Y Sasaki H Fusamoto T Kamada 1991 Expression of X protein and hepatitis B virus replication in chronic hepatitis Hepatology 13 417 421 10.1002/hep.1840130306 1:STN:280: DyaK3M7ltlOltA%3D%3D 1999313
15. J Hoare F Henkler JJ Dowling W Errington RD Goldin D Fish MJ McGarvey 2001 Subcellular localisation of the X protein in HBV infected hepatocytes J Med Virol 64 419 426 10.1002/jmv.1067 1:STN:280:DC%2BD3MvhvVanuw%3D%3D 11468725 (Pubitemid 32613727)
16. J Pal C Somogyi AA Szmolenszky G Szekeres J Sipos G Hegedus I Martzinovits J Molnar P Nemeth 2001 Immunohistochemical assessment and prognostic value of hepatitis B virus X protein in chronic hepatitis and primary hepatocellular carcinomas using anti-HBxAg monoclonal antibody Pathol Oncol Res 7 178 184 10.1007/BF03032346 1:CAS:528:DC%2BD3MXoslams78%3D 11692143
17. JH Seo KM Kim S Murakami BC Park 1997 Lack of colocalization of HBxAg, insulin like growth factor II in the livers of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma J Korean Med Sci 12 523 531 1:CAS:528:DyaK1cXkslaktQ%3D%3D 9443091
18. K Suzuki T Uchida T Shikata M Moriyama Y Aratawa M Mizokami F Mima 1990 Expression of pre-S1, pre-S2, S and X peptides in relation to viral replication in livers with chronic hepatitis B Liver 10 355 364 1:STN:280: DyaK3M7mtlaqtA%3D%3D 2074733
19. L Vitvitski-Trepo A Kay C Pichoud P Chevallier S de Dinechin BM Shamoon E Mandart C Trepo F Galibert 1990 Early and frequent detection of HBxAg and/or anti-HBx in hepatitis B virus infection Hepatology 12 1278 1283 10.1002/hep.1840120605 1:STN:280:DyaK3M%2FnvVOlsw%3D%3D 2258144
20. WL Wang WT London L Lega MA Feitelson 1991 HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis Hepatology 14 29 37 10.1002/hep.1840140106 1:STN:280:DyaK3M3ptlOhug%3D%3D 1712339
21. H Zentgraf G Herrmann R Klein P Schranz I Loncarevic D Herrmann K Hubner CH Schroder 1990 Mouse monoclonal antibody directed against hepatitis B virus X protein synthesized in Escherichia coli: Detection of reactive antigen in liver cell carcinoma and chronic hepatitis Oncology 47 143 148 10.1159/000226807 1:STN:280:DyaK3c7ptFGmsw%3D%3D 2156203
22. GY Hwang CY Lin LM Huang YH Wang JC Wang CT Hsu SS Yang CC Wu 2003 Detection of the hepatitis B virus X protein (HBx) antigen and anti-HBx antibodies in cases of human hepatocellular carcinoma J Clin Microbiol 41 5598 5603 10.1128/JCM.41.12.5598-5603.2003 1:CAS:528:DC%2BD2cXjtF2isA%3D%3D 14662947 (Pubitemid 37543252)
23. XZ Wang XC Chen YX Chen LJ Zhang D Li FL Chen ZX Chen HY Chen QM Tao 2003 Overexpression of HBxAg in hepatocellular carcinoma and its relationship with Fas/FasL system World J Gastroenterol 9 2671 2675 1:CAS:528: DC%2BD2cXmt1CmtA%3D%3D 14669310