-
4
-
-
0003660996
-
-
Li, J. J.; Gribble, G. W., Eds. Pergamon: Oxford, UK
-
(d) Li, J. J.; Gribble, G. W., Eds. Palladium in Heterocyclic Chemistry; Pergamon: Oxford, UK, 2000.
-
(2000)
Palladium in Heterocyclic Chemistry
-
-
-
6
-
-
33744870975
-
-
(b) Larock, R. C; Yum, E. K.; Refvik, M. D. J. Org. Chem. 1998, 63, 7652-7662.
-
(1998)
J. Org. Chem.
, vol.63
, pp. 7652-7662
-
-
Larock, R.C.1
Yum, E.K.2
Refvik, M.D.3
-
7
-
-
0002103980
-
-
(a) Sakamoto, T.; Kondo, Y.; Yamanaka, H. Heterocycles 1986, 24, 31-32.
-
(1986)
Heterocycles
, vol.24
, pp. 31-32
-
-
Sakamoto, T.1
Kondo, Y.2
Yamanaka, H.3
-
8
-
-
0001018661
-
-
(b) Kakamoto, T.; Kondo, Y.; Yamanaka, H. Heterocycles 1986, 24, 1845-1847.
-
(1986)
Heterocycles
, vol.24
, pp. 1845-1847
-
-
Kakamoto, T.1
Kondo, Y.2
Yamanaka, H.3
-
9
-
-
34250736336
-
-
(a) Barluenga, J.; Jiménez-Aquino, A.; Valdés, C; Aznar, F. Angew. Chem.. Int. Ed. Engl. 2007, 46, 1529-1532.
-
(2007)
Angew. Chem.. Int. Ed. Engl.
, vol.46
, pp. 1529-1532
-
-
Barluenga, J.1
Jiménez-Aquino, A.2
Valdés, C.3
Aznar, F.4
-
10
-
-
67749120541
-
-
(b) Barluenga, J.; Jiménez-Aquino, A.; Aznar, F.; Valdés, C. J. Am. Chem. Soc. 2009, 131, 4031-4041.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 4031-4041
-
-
Barluenga, J.1
Jiménez-Aquino, A.2
Aznar, F.3
Valdés, C.4
-
11
-
-
12344275854
-
-
(a) Willis, M. C.; Brace, G. N.; Holmes, I. P. Angew. Chem., Int. Ed. Engl. 2005, 44, 403-406.
-
(2005)
Angew. Chem., Int. Ed. Engl.
, vol.44
, pp. 403-406
-
-
Willis, M.C.1
Brace, G.N.2
Holmes, I.P.3
-
13
-
-
58849108959
-
-
(c) Hodgkinson, R. C.; Schulz, J.; Willis, M. C. Org. Biomol. Chem. 2009, 7, 432-434.
-
(2009)
Org. Biomol. Chem.
, vol.7
, pp. 432-434
-
-
Hodgkinson, R.C.1
Schulz, J.2
Willis, M.C.3
-
14
-
-
60749137679
-
-
Tadd, A. C.; Matsuno, A.; Fielding, M. R.; Willis, M. C. Org. Lett. 2009, 11, 583-586.
-
(2009)
Org. Lett.
, vol.11
, pp. 583-586
-
-
Tadd, A.C.1
Matsuno, A.2
Fielding, M.R.3
Willis, M.C.4
-
15
-
-
0035951552
-
-
(a) Olofsson, K.; Sahlin, H.; Larhed, M.; Hallberg, A. J. Org. Chem. 2001, 66, 544-549.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 544-549
-
-
Olofsson, K.1
Sahlin, H.2
Larhed, M.3
Hallberg, A.4
-
16
-
-
0038584673
-
-
(b) For a discussion of mechanism and regioselectivity in the Heck reaction, see: Cabri, W.; Candiani, I. Acc. Chem. Res. 1995, 28, 2-7.
-
(1995)
Acc. Chem. Res.
, vol.28
, pp. 2-7
-
-
Cabri, W.1
Candiani, I.2
-
17
-
-
38549087936
-
-
Jensen, T.; Pedersen, H.; Bang-Andersen, B.; Madsen, R.; Jørgensen, M. Angew. Chem., Int. Ed. Engl. 2008, 47, 888-890.
-
(2008)
Angew. Chem., Int. Ed. Engl.
, vol.47
, pp. 888-890
-
-
Jensen, T.1
Pedersen, H.2
Bang-Andersen, B.3
Madsen, R.4
Jørgensen, M.5
-
18
-
-
76849085473
-
-
See the Supporting Information for the synthesis of the chlorotriflates from the corresponding chlorophenols
-
See the Supporting Information for the synthesis of the chlorotriflates from the corresponding chlorophenols.
-
-
-
-
19
-
-
76849097279
-
-
o-Bromo triflates were found to not be as efficient in the Heck reaction
-
o-Bromo triflates were found to not be as efficient in the Heck reaction.
-
-
-
-
20
-
-
76849102605
-
-
For the full table from the base screen, please see the Supporting Information
-
For the full table from the base screen, please see the Supporting Information.
-
-
-
-
21
-
-
76849087677
-
-
CuI (10 mol %) with L-proline (20 mol %) also gave a small amount of the desired methylene-substituted indoline (11%). Attempts to optimize this proved fruitless with messy reaction profiles, forming multiple products
-
CuI (10 mol %) with L-proline (20 mol %) also gave a small amount of the desired methylene-substituted indoline (11%). Attempts to optimize this proved fruitless with messy reaction profiles, forming multiple products.
-
-
-
-
22
-
-
76849102969
-
-
Investigations into a single catalyst system for the Heck reaction and cyclization have so far proved elusive
-
Investigations into a single catalyst system for the Heck reaction and cyclization have so far proved elusive.
-
-
-
-
23
-
-
33748238143
-
-
Tietze, L. F.; Buhr, W. Angew. Chem., Int. Ed. Engl. 1995, 34, 1366-1368.
-
(1995)
Angew. Chem., Int. Ed. Engl.
, vol.34
, pp. 1366-1368
-
-
Tietze, L.F.1
Buhr, W.2
-
24
-
-
76849114180
-
-
While it was possible to directly charge CSA at the end of the cyclization reaction, the process benefitted from a quick aqueous workup prior to addition of CSA
-
While it was possible to directly charge CSA at the end of the cyclization reaction, the process benefitted from a quick aqueous workup prior to addition of CSA.
-
-
-
-
26
-
-
58149296140
-
-
(b) Ma, J.; Yin, W.; Zhou, H.; Liao, X.; Cook, J. M. J. Org. Chem. 2009, 74, 264-273.
-
(2009)
J. Org. Chem.
, vol.74
, pp. 264-273
-
-
Ma, J.1
Yin, W.2
Zhou, H.3
Liao, X.4
Cook, J.M.5
-
29
-
-
8244236706
-
-
(e) Sakamoto, T.; Kondo, Y.; Uchiyama, M.; Yamanaka, H. J. Chem. Soc., Perkin Trans. 1 1993, 1941-1942.
-
(1993)
J. Chem. Soc., Perkin Trans. 1
, pp. 1941-1942
-
-
Sakamoto, T.1
Kondo, Y.2
Uchiyama, M.3
Yamanaka, H.4
-
31
-
-
64249155932
-
-
Qiu, X.-L.; Zhu, J.; Wu, G.; Lee, W.-H.; Chamberlain, A. R. J. Org. Chem. 2009, 74, 2018-2027.
-
(2009)
J. Org. Chem.
, vol.74
, pp. 2018-2027
-
-
Qiu, X.-L.1
Zhu, J.2
Wu, G.3
Lee, W.-H.4
Chamberlain, A.R.5
-
32
-
-
0034675393
-
-
Tsai, Y.; Dukat, M.; Slassi, A.; MacLean, N.; Demchyshyn, L.: Savage, J. E.; Roth, B. L.; Hufesein, S.; Lee, M.; Glennon, R. A. Bioorg. Med. Chem. Lett. 2000, 10, 2295-2299.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 2295-2299
-
-
Tsai, Y.1
Dukat, M.2
Slassi, A.3
MacLean, N.4
Demchyshyn, L.5
Savage, J.E.6
Roth, B.L.7
Hufesein, S.8
Lee, M.9
Glennon, R.A.10
|