메뉴 건너뛰기




Volumn 17, Issue 3, 2010, Pages 180-191

Antitumor activity of Ad-IU2, a prostate-specific replication-competent adenovirus encoding the apoptosis inducer, TRAIL

Author keywords

Adenovirus; Prostate cancer; PSES; TRAIL

Indexed keywords

ADENOVIRUS VECTOR; ADNOVIRUS VECTOR IU2; ANDROGEN; PROSTATE SPECIFIC ANTIGEN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 76749161757     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2009.62     Document Type: Article
Times cited : (11)

References (55)
  • 4
    • 0036682025 scopus 로고    scopus 로고
    • Radical radiation for localized prostate cancer: Local persistence of disease results in a late wave of metastases
    • Coen JJ, Zietman AL, Thakral H, Shipley WU. Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases. J Clin Oncol 2002; 20: 3199-3205.
    • (2002) J Clin Oncol , vol.20 , pp. 3199-3205
    • Coen, J.J.1    Zietman, A.L.2    Thakral, H.3    Shipley, W.U.4
  • 5
    • 0034817278 scopus 로고    scopus 로고
    • Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. the 15-year Johns Hopkins experience
    • Han M, Partin AW, Pound CR, Epstein JI, Walsh PC. Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urol Clin North Am 2001; 28: 555-565.
    • (2001) Urol Clin North Am , vol.28 , pp. 555-565
    • Han, M.1    Partin, A.W.2    Pound, C.R.3    Epstein, J.I.4    Walsh, P.C.5
  • 6
    • 0015370976 scopus 로고
    • Studies on prostatic cancer. I. the effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. CA Cancer J Clin 1972; 22: 232-240.
    • (1972) CA Cancer J Clin , vol.22 , pp. 232-240
    • Huggins, C.1    Hodges, C.V.2
  • 9
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH, Lara Jr PN, Jones JA, Taplin ME et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004; 351: 1513-1520.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3    Lara Jr, P.N.4    Jones, J.A.5    Taplin, M.E.6
  • 10
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351: 1502-1512.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3    Horti, J.4    Pluzanska, A.5    Chi, K.N.6
  • 11
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3: 673-682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5    Nicholl, J.K.6
  • 12
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • DOI 10.1074/jbc.271.22.12687
    • Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996; 271: 12687-12690. (Pubitemid 26175834)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.22 , pp. 12687-12690
    • Pitti, R.M.1    Marsters, S.A.2    Ruppert, S.3    Donahue, C.J.4    Moore, A.5    Ashkenazi, A.6
  • 14
    • 0030762815 scopus 로고    scopus 로고
    • An antagonist decoy receptor and a death domain-containing receptor for TRAIL
    • Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277: 815-818.
    • (1997) Science , vol.277 , pp. 815-818
    • Pan, G.1    Ni, J.2    Wei, Y.F.3    Yu, G.4    Gentz, R.5    Dixit, V.M.6
  • 15
    • 0034682802 scopus 로고    scopus 로고
    • Accelerated Publication - FADD is required for DR4- and DR5-mediated apoptosis. Lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts
    • DOI 10.1074/jbc.C000284200
    • Kuang AA, Diehl GE, Zhang J, Winoto A. FADD is required for DR4-and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. J Biol Chem 2000; 275: 25065-25068. (Pubitemid 30686995)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.33 , pp. 25065-25068
    • Kuang, A.A.1    Diehl, G.E.2    Zhang, J.3    Winoto, A.4
  • 16
    • 0035137696 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    • DOI 10.1038/83416
    • Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001; 7: 94-100. (Pubitemid 32095647)
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 94-100
    • Takeda, K.1    Hayakawa, Y.2    Smyth, M.J.3    Kayagaki, N.4    Yamaguchi, N.5    Kakuta, S.6    Iwakura, Y.7    Yagita, H.8    Okumura, K.9
  • 17
    • 0031414749 scopus 로고    scopus 로고
    • The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
    • Degli-Esposti MA, Dougall WC, Smolak PJ, Waugh JY, Smith CA, Goodwin RG. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 1997; 7: 813-820.
    • (1997) Immunity , vol.7 , pp. 813-820
    • Degli-Esposti, M.A.1    Dougall, W.C.2    Smolak, P.J.3    Waugh, J.Y.4    Smith, C.A.5    Goodwin, R.G.6
  • 19
    • 0035815649 scopus 로고    scopus 로고
    • Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis
    • Nesterov A, Lu X, Johnson M, Miller GJ, Ivashchenko Y, Kraft AS. Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. J Biol Chem 2001; 276: 10767-10774.
    • (2001) J Biol Chem , vol.276 , pp. 10767-10774
    • Nesterov, A.1    Lu, X.2    Johnson, M.3    Miller, G.J.4    Ivashchenko, Y.5    Kraft, A.S.6
  • 20
    • 14644437742 scopus 로고    scopus 로고
    • Mechanisms of resistance to TRAIL-induced apoptosis in cancer
    • Zhang L, Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther 2005; 12: 228-237.
    • (2005) Cancer Gene Ther , vol.12 , pp. 228-237
    • Zhang, L.1    Fang, B.2
  • 21
    • 0036167572 scopus 로고    scopus 로고
    • Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL
    • Voelkel-Johnson C, King DL, Norris JS. Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL. Cancer Gene Ther 2002; 9: 164-172.
    • (2002) Cancer Gene Ther , vol.9 , pp. 164-172
    • Voelkel-Johnson, C.1    King, D.L.2    Norris, J.S.3
  • 22
    • 11844293509 scopus 로고    scopus 로고
    • Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo
    • Shankar S, Chen X, Srivastava RK. Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo. Prostate 2005; 62: 165-186.
    • (2005) Prostate , vol.62 , pp. 165-186
    • Shankar, S.1    Chen, X.2    Srivastava, R.K.3
  • 23
    • 4143083851 scopus 로고    scopus 로고
    • Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms
    • Shankar S, Singh TR, Srivastava RK. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: intracellular mechanisms. Prostate 2004; 61: 35-49.
    • (2004) Prostate , vol.61 , pp. 35-49
    • Shankar, S.1    Singh, T.R.2    Srivastava, R.K.3
  • 26
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 2000; 6: 564-567.
    • (2000) Nat Med , vol.6 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6
  • 28
    • 0036764799 scopus 로고    scopus 로고
    • Novel prostate-specific promoter derived from PSA and PSMA enhancers
    • Lee SJ, Kim HS, Yu R, Lee K, Gardner TA, Jung C et al. Novel prostate-specific promoter derived from PSA and PSMA enhancers. Mol Ther 2002; 6: 415-421.
    • (2002) Mol Ther , vol.6 , pp. 415-421
    • Lee, S.J.1    Kim, H.S.2    Yu, R.3    Lee, K.4    Gardner, T.A.5    Jung, C.6
  • 30
    • 0030024402 scopus 로고    scopus 로고
    • Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors
    • Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC et al. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 1996; 7: 215-222.
    • (1996) Hum Gene Ther , vol.7 , pp. 215-222
    • Fallaux, F.J.1    Kranenburg, O.2    Cramer, S.J.3    Houweling, A.4    Van Ormondt, H.5    Hoeben, R.C.6
  • 33
    • 0028321891 scopus 로고
    • Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells
    • Wu HC, Hsieh JT, Gleave ME, Brown NM, Pathak S, Chung LW. Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells. Int J Cancer 1994; 57: 406-412.
    • (1994) Int J Cancer , vol.57 , pp. 406-412
    • Wu, H.C.1    Hsieh, J.T.2    Gleave, M.E.3    Brown, N.M.4    Pathak, S.5    Chung, L.W.6
  • 34
    • 0018779369 scopus 로고
    • Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
    • Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW. Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 1979; 17: 16-23.
    • (1979) Invest Urol , vol.17 , pp. 16-23
    • Kaighn, M.E.1    Narayan, K.S.2    Ohnuki, Y.3    Lechner, J.F.4    Jones, L.W.5
  • 36
    • 20144387357 scopus 로고    scopus 로고
    • Gene therapy for prostate cancer by controlling adenovirus E1a and E4 gene expression with PSES enhancer
    • Li X, Zhang YP, Kim HS, Bae KH, Stantz KM, Lee SJ et al. Gene therapy for prostate cancer by controlling adenovirus E1a and E4 gene expression with PSES enhancer. Cancer Res 2005; 65: 1941-1951.
    • (2005) Cancer Res , vol.65 , pp. 1941-1951
    • Li, X.1    Zhang, Y.P.2    Kim, H.S.3    Bae, K.H.4    Stantz, K.M.5    Lee, S.J.6
  • 37
    • 57649118854 scopus 로고    scopus 로고
    • Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter
    • Ahn M, Lee SJ, Li X, Jimenez JA, Zhang YP, Bae KH et al. Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter. Cancer Gene Ther 2009; 16: 73-82.
    • (2009) Cancer Gene Ther , vol.16 , pp. 73-82
    • Ahn, M.1    Lee, S.J.2    Li, X.3    Jimenez, J.A.4    Zhang, Y.P.5    Bae, K.H.6
  • 39
    • 0034855468 scopus 로고    scopus 로고
    • Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus
    • Griffith TS, Broghammer EL. Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus. Mol Ther 2001; 4: 257-266.
    • (2001) Mol Ther , vol.4 , pp. 257-266
    • Griffith, T.S.1    Broghammer, E.L.2
  • 40
    • 2342453303 scopus 로고    scopus 로고
    • A tumor-targeted and conditionally replicating oncolytic ade-novirus vector expressing TRAIL for treatment of liver metastases
    • Sova P, Ren XW, Ni S, Bernt KM, Mi J, Kiviat N et al. A tumor-targeted and conditionally replicating oncolytic ade-novirus vector expressing TRAIL for treatment of liver metastases. Mol Ther 2004; 9: 496-509.
    • (2004) Mol Ther , vol.9 , pp. 496-509
    • Sova, P.1    Ren, X.W.2    Ni, S.3    Bernt, K.M.4    Mi, J.5    Kiviat, N.6
  • 41
    • 8844280122 scopus 로고    scopus 로고
    • Enhanced TRAIL sensitivity by E1A expression in human cancer and normal cell lines: Inhibition by adenovirus E1B19K and E3 proteins
    • Hu B, Zhu H, Qiu S, Su Y, Ling W, Xiao W et al. Enhanced TRAIL sensitivity by E1A expression in human cancer and normal cell lines: inhibition by adenovirus E1B19K and E3 proteins. Biochem Biophys Res Commun 2004; 325: 1153-1162.
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 1153-1162
    • Hu, B.1    Zhu, H.2    Qiu, S.3    Su, Y.4    Ling, W.5    Xiao, W.6
  • 42
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274: 373-376.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3    Heise, C.4    Horn, S.5    Muna, M.6
  • 43
    • 0031743945 scopus 로고    scopus 로고
    • Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
    • Rothmann T, Hengstermann A, Whitaker NJ, Scheffner M, zur Hausen H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J Virol 1998; 72: 9470-9478.
    • (1998) J Virol , vol.72 , pp. 9470-9478
    • Rothmann, T.1    Hengstermann, A.2    Whitaker, N.J.3    Scheffner, M.4    Zur Hausen, H.5
  • 44
    • 12944328660 scopus 로고    scopus 로고
    • A phase i study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
    • Ganly I, Kirn D, Eckhardt G, Rodriguez GI, Soutar DS, Otto R et al. A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin Cancer Res 2000; 6: 798-806.
    • (2000) Clin Cancer Res , vol.6 , pp. 798-806
    • Ganly, I.1    Kirn, D.2    Eckhardt, G.3    Rodriguez, G.I.4    Soutar, D.S.5    Otto, R.6
  • 46
    • 0033166096 scopus 로고    scopus 로고
    • A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma
    • Hallenbeck PL, Chang YN, Hay C, Golightly D, Stewart D, Lin J et al. A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma. Hum Gene Ther 1999; 10: 1721-1733.
    • (1999) Hum Gene Ther , vol.10 , pp. 1721-1733
    • Hallenbeck, P.L.1    Chang, Y.N.2    Hay, C.3    Golightly, D.4    Stewart, D.5    Lin, J.6
  • 47
    • 0035881263 scopus 로고    scopus 로고
    • A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis
    • Matsubara S, Wada Y, Gardner TA, Egawa M, Park MS, Hsieh CL et al. A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res 2001; 61: 6012-6019.
    • (2001) Cancer Res , vol.61 , pp. 6012-6019
    • Matsubara, S.1    Wada, Y.2    Gardner, T.A.3    Egawa, M.4    Park, M.S.5    Hsieh, C.L.6
  • 48
    • 0030790684 scopus 로고    scopus 로고
    • Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
    • Rodriguez R, Schuur ER, Lim HY, Henderson GA, Simons JW, Henderson DR. Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. Cancer Res 1997; 57: 2559-2563.
    • (1997) Cancer Res , vol.57 , pp. 2559-2563
    • Rodriguez, R.1    Schuur, E.R.2    Lim, H.Y.3    Henderson, G.A.4    Simons, J.W.5    Henderson, D.R.6
  • 49
    • 0033199188 scopus 로고    scopus 로고
    • The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts
    • Yu DC, Chen Y, Seng M, Dilley J, Henderson DR. The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts. Cancer Res 1999; 59: 4200-4203.
    • (1999) Cancer Res , vol.59 , pp. 4200-4203
    • Yu, D.C.1    Chen, Y.2    Seng, M.3    Dilley, J.4    Henderson, D.R.5
  • 50
    • 0036606008 scopus 로고    scopus 로고
    • A novel targeting modality to enhance adenoviral replication by vitamin D(3) in androgen-independent human prostate cancer cells and tumors
    • Hsieh CL, Yang L, Miao L, Yeung F, Kao C, Yang H et al. A novel targeting modality to enhance adenoviral replication by vitamin D(3) in androgen-independent human prostate cancer cells and tumors. Cancer Res 2002; 62: 3084-3092.
    • (2002) Cancer Res , vol.62 , pp. 3084-3092
    • Hsieh, C.L.1    Yang, L.2    Miao, L.3    Yeung, F.4    Kao, C.5    Yang, H.6
  • 51
    • 0034928059 scopus 로고    scopus 로고
    • Induced apoptosis supports spread of adenovirus vectors in tumors
    • Mi J, Li ZY, Ni S, Steinwaerder D, Lieber A. Induced apoptosis supports spread of adenovirus vectors in tumors. Hum Gene Ther 2001; 12: 1343-1352.
    • (2001) Hum Gene Ther , vol.12 , pp. 1343-1352
    • Mi, J.1    Li, Z.Y.2    Ni, S.3    Steinwaerder, D.4    Lieber, A.5
  • 52
    • 0035125735 scopus 로고    scopus 로고
    • Tumor-specific gene expression in hepatic metas-tases by a replication-activated adenovirus vector
    • Steinwaerder DS, Carlson CA, Otto DL, Li ZY, Ni S, Lieber A. Tumor-specific gene expression in hepatic metas-tases by a replication-activated adenovirus vector. Nat Med 2001; 7: 240-243.
    • (2001) Nat Med , vol.7 , pp. 240-243
    • Steinwaerder, D.S.1    Carlson, C.A.2    Otto, D.L.3    Li, Z.Y.4    Ni, S.5    Lieber, A.6
  • 53
    • 11144354510 scopus 로고    scopus 로고
    • Combination of targeting gene-virotherapy with 5-FU enhances antitumor efficacy in malignant colorectal carcinoma
    • Qiu S, Ruan H, Pei Z, Hu B, Lan P, Wang J et al. Combination of targeting gene-virotherapy with 5-FU enhances antitumor efficacy in malignant colorectal carcinoma. J Interferon Cytokine Res 2004; 24: 219-230.
    • (2004) J Interferon Cytokine Res , vol.24 , pp. 219-230
    • Qiu, S.1    Ruan, H.2    Pei, Z.3    Hu, B.4    Lan, P.5    Wang, J.6
  • 54
    • 33749011709 scopus 로고    scopus 로고
    • Eliminating established tumor in nu/nu nude mice by a tumor necrosis factor-alpha-related apoptosis-inducing li-gand-armed oncolytic adenovirus
    • Dong F, Wang L, Davis JJ, Hu W, Zhang L, Guo W et al. Eliminating established tumor in nu/nu nude mice by a tumor necrosis factor-alpha-related apoptosis-inducing li-gand-armed oncolytic adenovirus. Clin Cancer Res 2006; 12: 5224-5230.
    • (2006) Clin Cancer Res , vol.12 , pp. 5224-5230
    • Dong, F.1    Wang, L.2    Davis, J.J.3    Hu, W.4    Zhang, L.5    Guo, W.6
  • 55
    • 30944463601 scopus 로고    scopus 로고
    • A tumor-specific conditionally replicative adenovirus vector expressing TRAIL for gene therapy of hepatocellular carcinoma
    • Ren XW, Liang M, Meng X, Ye X, Ma H, Zhao Y et al. A tumor-specific conditionally replicative adenovirus vector expressing TRAIL for gene therapy of hepatocellular carcinoma. Cancer Gene Ther 2006; 13: 159-168.
    • (2006) Cancer Gene Ther , vol.13 , pp. 159-168
    • Ren, X.W.1    Liang, M.2    Meng, X.3    Ye, X.4    Ma, H.5    Zhao, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.