A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease

Kidney International

Volumn 77, Issue 5, 2010, Pages 450-458

  Niemczyk, Stanisaw ^a   Sikorska, Hanna ^b   Wiȩcek, Andrzej ^c   Zukowska Szczechowska, Ewa ^c   Zalȩcka, Klaudia ^d   Gorczyńska, Joanna ^d   Kubik, Magorzata ^c   Czerwieńska, Beata ^b   Gosek, Katarzyna ^c   Veldhuis, Johannes D ^e   Wagner, David A ^f   Gaudreau, Pierrette ^g   Hakonen, Tiina ^h   Kay, Sam Wai Kit ^b   Jouhikainen, Taneli ^b   Schaefer, Franz ⁱ  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b Akela Pharma Inc   (Canada)

^c MEDICAL UNIVERSITY OF SILESIA   (Poland)

^d Public Hospital   (Poland)

^e Mayo Clinic   (United States)

^f METABOLIC SOLUTIONS INC   (United States)

^g CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^h Encorium Oy   (Finland)

ⁱ UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Body composition; Chronic kidney disease; Growth hormone; Malnutrition

Indexed keywords

AKL 0707; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; NITROGEN; PLACEBO; SOMATOMEDIN C; UNCLASSIFIED DRUG; UREA;

ACIDOSIS; ADULT; ANGINA PECTORIS; ARTICLE; BLOOD SAMPLING; BODY FAT DISTRIBUTION; BODY MASS; CHRONIC KIDNEY DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG FEVER; DUAL ENERGY X RAY ABSORPTIOMETRY; EDEMA; ERYTHROCYTE COUNT; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HEART ARREST; HEART FAILURE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERCALCEMIA; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INJECTION SITE CONTUSION; INJECTION SITE PAIN; MALE; NAUSEA; NEUTROPHILIA; NUTRITIONAL STATUS; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; UREA BLOOD LEVEL; UREMIA; URINARY TRACT INFECTION; VOMITING; XEROSTOMIA;

EID: 76749153828     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.480     Document Type: Article

References (33)

1. Fouque D, Kalantar-Zadeh K, Kopple J et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 2008; 73: 391-398.
2. Kalantar-Zadeh K, Kopple JD, Block G et al. A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients. Am J Kidney Dis 2001; 38: 1251-1263.
3. Rabkin R, Sun DF, Chen Y et al. Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr Nephrol 2005; 20: 313-318.
4. Iglesias P, Diez JJ, Fernandez-Reyes MJ et al. Growth hormone, IGF-1 and its binding proteins (IGFBP-1 and-3) in adult uraemic patients undergoing peritoneal dialysis and haemodialysis. Clin Endocrinol (Oxf) 2004; 60: 741-749.
5. Powell DR, Liu F, Baker BK et al. Insulin-like growth factor-1 and its binding proteins as growth inhibitors in children with chronic renal failure. Pediatr Nephrol 1996; 10: 343-347.
6. Ding H, Gao X-L, Hirschberg R et al. Impaired actions of insulin-like growth factor-1 on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect. J Clin Invest 1996; 97: 1064-1075.
7. Pupim LB, Flacoll PJ, Yu C et al. Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients. Am J Clin Nutr 2005; 82: 1235-1243.
8. Iglesias P, Diez J, Fernandez-Reyes MJ et al. Recombinant human growth hormone therapy in malnourished dialysis patients: a randomized controlled study. Am J Kidney Dis 1998; 32: 454-463.
9. Johannsson G, Bengtsson BA, Ahlmen J. Double-blind, placebo-controlled study of growth hormone treatment in elderly patients undergoing chronic hemodialysis: anabolic effect and functional improvement. Am J Kidney Dis 1999; 33: 709-717.
10. Jensen PB, Hansen TB, Frystyk J et al. Growth hormone, insulin-like growth factors and their binding proteins in adult hemodialysis patients treated with recombinant human growth hormone. Clin Nephrol 1999; 52: 103-109.
11. Feldt-Rasmussen B, Lange M, Sulowicz W et al. Growth hormone treatment during hemodialysis in a randomized trial improves nutrition, quality of life, and cardiovascular risk. J Am Soc Nephrol 2007; 18: 2161-2171.
12. Kotzmann H, Yilmaz N, Lercher P et al. Differential effects of growth hormone therapy in malnourished hemodialysis patients. Kidney Int 2001; 60: 1578-1585.
13. Corpas E, Harman SM, Pineyro MA et al. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab 1992; 75: 530-535.
14. Hulse JA, Rosenthal SM, Cuttler L et al. The effects of pulsatile administration, continuous infusion, and diurnal variation on the growth hormone (GH) response to GH-releasing hormone in normal men. J Clin Endocrinol Metab 1986; 63: 872-878.
15. Gaudreau P. GHRH analogues. PCT Application WO/2004/027064 A2. 1 April 2004.
16. Tönshoff B, Blum WF, Wingen AM et al. Serum insulin-like growth factors (IGFs) and IGF binding proteins 1, 2, and 3 in children with chronic renal failure: relationship to height and glomerular filtration rate. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Clin Endocrinol Metab 1995; 80: 2684-2691.
17. Mahesh S, Kaskel F. Growth hormone axis in chronic kidney disease. Pediatr Nephrol 2008; 23: 41-48.
18. Makhija S, Baker J. The Subjective Global Assessment: a review of its use in clinical practice. Nutr Clin Pract 2008; 23: 405-409.
19. Gravholt CH, Schmitz O, Simonsen L et al. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol 1999; 277: E848-E854.
20. Harman SM, Blackman MR. The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men. Horm Res 2003; 60(Suppl 1): 121-124.
21. Hansen TB, Gram J, Jensen PB et al. Influence of growth hormone on whole body and regional soft tissue composition in adult patients on hemodialysis. A double-blind, randomized, placebo-controlled study. Clin Nephrol 2000; 53: 99-107.
22. Veldhuis JD, Patrie JM, Frick K et al. Administration of recombinant human GHRH-1,44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women. Eur J Endocrinol 2005; 153: 669-677.
23. Falutz J, Allas S, Blot K et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med 2007; 357: 2359-2370.
24. Davidson P, Milne R, Chase D et al. Growth hormone replacement in adults and bone mineral density: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 2004; 60: 92-98.
25. Ohlsson C, Bengtsson BA, Isaksson OG et al. Growth hormone and bone. Endocr Rev 1998; 19: 55-79.
26. Goodship THJ, Mitch WE, Hoerr RA et al. Adaptation to low protein diets in renal failure: leucine turnover and nitrogen balance. J Am Soc Nephrol 1990; 1: 66-75.
27. Reaich D, Channon SM, Scrimgeour CM et al. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol 1993; 265: E230-E235.
28. Burt MG, Gibney J, Hoffman DM et al. Relationship between GH-induced metabolic changes and changes in body composition: a dose and time course study in GH-deficient adults. Growth Horm IGF Res 2008; 18: 55-64.
29. McCann L. Subjective Global Assessment as it pertains to the nutritional status of dialysis patients. E-NEPH Archive: Dial Transplant 1996; 25: 190-197.
30. Chattopadhyay S, Veldhuis JD, Keenan DM. Probabilistic recovery of pulsatile, secretory and kinetic structure: an alternating discrete and continuous schema. Quarterly Appl Math 2008; 66: 401-421.
31. Keenan DM, Roelfsema F, Biermasz N et al. Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis. Am J Physiol 2003; 285: R664-R673.
32. 13C]leucine. Am J Physiol 1980; 328: E473-E479.
33. Shi J, Sekhar RV, Balasubramanyam A et al. Short-and long-term effects of growth hormone (GH) replacement on protein metabolism in GH-deficient adults. J Clin Endocrinol Metab 2003; 88: 5827-5833.