Short- and Long-Term Effects of Growth Hormone (GH) Replacement on Protein Metabolism in GH-Deficient Adults

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 12, 2003, Pages 5827-5833

  Shi, Jianjian ^a   Sekhar, Rajagopal V ^a,b   Balasubramanyam, Ashok ^a,c   Ellis, Kenneth ^b   Reeds, Peter J ^b   Jahoor, Farook ^b   Sharma, Morali D ^a,c,d  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c BEN TAUB GENERAL HOSPITAL   (United States)

^d Division of Endocrinology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CARBON 13; DESMOPRESSIN; ESTROGEN; GLUCOCORTICOID; GROWTH HORMONE; HUMAN GROWTH HORMONE; HYDROCORTISONE; LEUCINE; PROGESTERONE; SEX HORMONE; TESTOSTERONE; THYROID HORMONE; TRACER; TRITIUM;

ADULT; AGED; ARTHRALGIA; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; EDEMA; FAT FREE MASS; FEEDING; FEMALE; FOLLOW UP; GROWTH HORMONE DEFICIENCY; HOMEOSTASIS; HORMONE SUBSTITUTION; HUMAN; HYPERGLYCEMIA; HYPOPITUITARISM; KINETICS; MALE; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ADULT; AGED; BODY COMPOSITION; CASE-CONTROL STUDIES; FASTING; FEMALE; HOMEOSTASIS; HUMAN GROWTH HORMONE; HUMANS; LEUCINE; MALE; METABOLISM, INBORN ERRORS; MIDDLE AGED; OXIDATION-REDUCTION; TIME FACTORS;

TRITIUM;

EID: 0347362881     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021943     Document Type: Article

References (14)

1. Salomon F, Cuneo R, Hesp, R, Sonksen PH 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-1803
2. Binnerts A, Swart GR, Wilson JH, Hoogerbrugge N, Pols HA, Birkenhager JC, Lamberts SW 1992 The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf) 37:79-87
3. Salomon F, Cuneo R, Sonksen PH 1991 Growth hormone and protein metabolism. Horm Res 36(Suppl 1):41-43
4. Vance ML, Mauras N 1999 Growth hormone therapy in adults and children. N Engl J Med 341:1206-1216
5. Carroll PV, Christ ER 1998 Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrinol Metab 83:382-395
6. Russell-Jones DL, Weissberger AJ, Bowes SB, Kelly JM, Thomason M, Umpleby AM, Jones RH, Sonksen PH 1993 The effects of growth hormone on protein metabolism in adult growth hormone deficient patients. Clin Endocrinol (Oxf) 38:427-431
7. Lucidi P, Laureti S, Santoni S, Lauten M, Busciantella-Ricci N, Angeletti G, Santeusanio F, De Feo P 2000 Adminstration of recombinant human growth hormone on alternate days is sufficient to increase whole body protein synthesis and lipolysis in growth hormone deficient adults. Clin Endocrinol (Oxf) 52:173-179
8. Russell-Jones DL, Bowes SB, Rees SE, Jackson NC, Weissberger AJ, Hovorka R, Sonksen PH, Umpleby AM 1998 Effect of growth hormone treatment on postprandial protein metabolism in growth hormone-deficient adults. Am J Physiol 274:E1050-E1056
9. Beshyah SA, Sharp PS, Gelding SV, Halliday D, Johnston DG 1993 Whole-body leucine turnover in adults on conventional treatment of hypopituitarism. Acta Endocrinol (Copenh) 129:158-164
10. Reid M, Badaloo A, Forrester T, Heird WC, Jahoor F 2002 Response of splanchnic and whole-body leucine kinetics to treatment of children with edematous protein-energy malnutrition accompanied by infection. Am J Clin Nutr 76:633-640
11. Jahoor F, Shangraw RE, Miyoshi H, Wallfish H, Herndon DN, Wolfe RR 1989 Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am J Physiol 257:E323-E331
12. Nissen S, Haymond MW, Changes in leucine kinetics during meal absorption: effects of dietary leucine availability. Am J Physiol 13:E695-E701
13. Fukagawa NK, Minaker KL, Rowe JW, Goodman MN, Matthews DE, Bier DM, Young VR 1985 Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men. J Clin Invest 76:2306-2311
14. Elahi D, McAloon-Dyke M, Fukagawa NK, Sclater AL, Wong GA, Shannon RP, Minaker KL, Miles JM, Rubenstein AH, Vandepol CJ 1993 Effects of recombinant human IGF-I on glucose and leucine kinetics in men. Am J Physiol 265:E831-E838