Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice

World Journal of Gastroenterology

Volumn 16, Issue 6, 2010, Pages 703-712

  Ruyssers, Nathalie E ^a   De Winter, Benedicte Y ^a   De Man, Joris G ^a   Ruyssers, Natacha D ^a   Van Gils, Ann J ^a   Loukas, Alex ^b   Pearson, Mark S ^b   Weinstock, Joel V ^c   Pelckmans, Paul A ^a   Moreels, Tom G ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Colitis; Crohn's disease; Gastrointestinal motility; Helminth proteins; Peristalsis; Schistosoma mansoni; Trinitrobenzene sulphate

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 5; PROTEIN; SCHISTOSOMA MANSONI PROTEIN; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; COLITIS; COLON MOTILITY; CONTROLLED STUDY; DESCENDING COLON; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EFFECTOR CELL; ENTERITIS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL MOTILITY DISORDER; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; STOMACH EMPTYING; T LYMPHOCYTE; TREATMENT OUTCOME; WORM;

EID: 76749147901     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i6.703     Document Type: Article

References (45)

1. Bamias G, Cominelli F. Novel strategies to attenuate immune activation in Crohn's disease. Curr Opin Pharmacol 2006; 6: 401-407
2. Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429
3. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115: 182-205
4. Alic M. Inflammatory bowel diseases are diseases of higher socioeconomic status: dogma or reality? Am J Gastroenterol 2000; 95: 3332-3333
5. Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax 2000; 55 Suppl 1: S2-S10
6. Lashner BA, Loftus EV Jr. True or false? The hygiene hypothesis for Crohn's disease. Am J Gastroenterol 2006; 101: 1003-1004
7. Weinstock JV, Summers RW, Elliott DE, Qadir K, Urban JF Jr, Thompson R. The possible link between de-worming and the emergence of immunological disease. J Lab Clin Med 2002; 139: 334-338
8. Moreels TG, Pelckmans PA. Gastrointestinal parasites: potential therapy for refractory inflammatory bowel diseases. Inflamm Bowel Dis 2005; 11: 178-184
9. Elliott DE, Li J, Blum A, Metwali A, Qadir K, Urban JF Jr, Weinstock JV. Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 2003; 284: G385-G391
10. Moreels TG, Nieuwendijk RJ, De Man JG, De Winter BY, Herman AG, Van Marck EA, Pelckmans PA. Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats. Gut 2004; 53: 99-107
11. Summers RW, Elliott DE, Urban JF Jr, Thompson R, Weinstock JV. Trichuris suis therapy in Crohn's disease. Gut 2005; 54: 87-90
12. Summers RW, Elliott DE, Urban JF Jr, Thompson RA, Weinstock JV. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology 2005; 128: 825-832
13. Ruyssers NE, De Winter BY, De Man JG, Loukas A, Herman AG, Pelckmans PA, Moreels TG. Worms and the treatment of inflammatory bowel disease: are molecules the answer? Clin Dev Immunol 2008; 2008: 567314
14. De Schepper HU, De Man JG, Moreels TG, Pelckmans PA, De Winter BY. Review article: gastrointestinal sensory and motor disturbances in inflammatory bowel disease - clinical relevance and pathophysiological mechanisms. Aliment Pharmacol Ther 2008; 27: 621-637
15. Kraneveld AD, Rijnierse A, Nijkamp FP, Garssen J. Neuroimmune interactions in inflammatory bowel disease and irritable bowel syndrome: future therapeutic targets. Eur J Pharmacol 2008; 585: 361-374
16. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology 1996; 111: 1683-1699
17. Geboes K, Collins S. Structural abnormalities of the nervous system in Crohn's disease and ulcerative colitis. Neurogastroenterol Motil 1998; 10: 189-202
18. Vermillion DL, Huizinga JD, Riddell RH, Collins SM. Altered small intestinal smooth muscle function in Crohn's disease. Gastroenterology 1993; 104: 1692-1699
19. Vrees MD, Pricolo VE, Potenti FM, Cao W. Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Arch Surg 2002; 137: 439-445; discussion 445-446
20. Reddy SN, Bazzocchi G, Chan S, Akashi K, Villanueva-Meyer J, Yanni G, Mena I, Snape WJ Jr. Colonic motility and transit in health and ulcerative colitis. Gastroenterology 1991; 101: 1289-1297
21. Kristinsson JO, Hopman WP, Oyen WJ, Drenth JP. Gastroparesis in patients with inactive Crohn's disease: a case series. BMC Gastroenterol 2007; 7: 11
22. Castiglione F, Del Vecchio Blanco G, Rispo A, Petrelli G, Amalfi G, Cozzolino A, Cuccaro I, Mazzacca G. Orocecal transit time and bacterial overgrowth in patients with Crohn's disease. J Clin Gastroenterol 2000; 31: 63-66
23. Annese V, Bassotti G, Napolitano G, Frusciante V, Bruno M, Conoscitore P, Germani U, Morelli A, Andriulli A. Gastric emptying of solids in patients with nonobstructive Crohn' s disease is sometimes delayed. J Clin Gastroenterol 1995; 21: 279-282
24. Kohno N, Nomura M, Okamoto H, Kaji M, Ito S. The use of electrogastrography and external ultrasonography to evaluate gastric motility in Crohn's disease. J Med Invest 2006; 53: 277-284
25. Moreels TG, De Man JG, De Winter BY, Timmermans JP, Herman AG, Pelckmans PA. Effect of 2,4,6-trinitrobenzenes ulphonic acid (TNBS)-induced ileitis on the motor function of non-inflamed rat gastric fundus. Neurogastroenterol Motil 2001; 13: 339-352
26. Neurath MF, Fuss I, Kelsall BL, Stüber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-1290
27. Ruyssers NE, De Winter BY, De Man JG, Loukas A, Pearson MS, Weinstock JV, Van den Bossche RM, Martinet W, Pelckmans PA, Moreels TG. Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice. Inflamm Bowel Dis 2009; 15: 491-500
28. Menachem Y, Trop S, Kolker O, Shibolet O, Alper R, Nagler A, Ilan Y. Adoptive transfer of NK 1.1+ lymphocytes in immune-mediated colitis: a pro-inflammatory or a tolerizing subgroup of cells? Microbes Infect 2005; 7: 825-835
29. Moreels TG, De Man JG, Bogers JJ, De Winter BY, Vrolix G, Herman AG, Van Marck EA, Pelckmans PA. Effect of Schistosoma mansoni-induced granulomatous inflammation on murine gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1030-G1042
30. Seerden TC, De Winter BY, Van Den Bossche RM, Herman AG, Pelckmans PA, De Man JG. Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis. Neurogastroenterol Motil 2005; 17: 671-679
31. Seerden TC, De Man JG, Holzer P, Van den Bossche RM, Herman AG, Pelckmans PA, De Winter BY. Experimental pancreatitis disturbs gastrointestinal and colonic motility in mice: effect of the prokinetic agent tegaserod. Neurogastroenterol Motil 2007; 19: 856-864
32. Mashimo H, Kjellin A, Goyal RK. Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. Gastroenterology 2000; 119: 766-773
33. Setiawan T, Metwali A, Blum AM, Ince MN, Urban JF Jr, Elliott DE, Weinstock JV. Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect Immun 2007; 75: 4655-4663
34. Weinstock JV, Summers RW, Elliott DE. Role of helminths in regulating mucosal inflammation. Springer Semin Immunopathol 2005; 27: 249-271
35. De Schepper HU, De Man JG, Van Nassauw L, Timmermans JP, Herman AG, Pelckmans PA, De Winter BY. Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve. Gut 2007; 56: 195-202
36. Khan WI, Collins SM. Immune-mediated alteration in gut physiology and its role in host defence in nematode infection. Parasite Immunol 2004; 26: 319-326
37. Khan WI, Collins SM. Gut motor function: immunological control in enteric infection and inflammation. Clin Exp Immunol 2006; 143: 389-397
38. Moreels TG, De Man JG, De Winter BY, Herman AG, Pelckmans PA. Effect of Interleukin-1beta on cholinergic contractions in the gastrointestinal tract of the rat. Anaesthesiol Intensivmed Notfallmed Schmerzther 1998; 33: 610
39. Akiho H, Blennerhassett P, Deng Y, Collins SM. Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 2002; 282: G226-G232
40. Stoffels B, Schmidt J, Nakao A, Nazir A, Chanthaphavong RS, Bauer AJ. Role of interleukin 10 in murine postoperative ileus. Gut 2009; 58: 648-660
41. Zhang Z, Hinrichs DJ, Lu H, Chen H, Zhong W, Kolls JK. After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease? Int Immunopharmacol 2007; 7: 409-416
42. Elliott DE, Summers RW, Weinstock JV. Helminths and the modulation of mucosal inflammation. Curr Opin Gastroenterol 2005; 21: 51-58
43. Smith P, Mangan NE, Walsh CM, Fallon RE, McKenzie AN, van Rooijen N, Fallon PG. Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J Immunol 2007; 178: 4557-4566
44. Kane CM, Cervi L, Sun J, McKee AS, Masek KS, Shapira S, Hunter CA, Pearce EJ. Helminth antigens modulate TLRinitiated dendritic cell activation. J Immunol 2004; 173: 7454-7461
45. Niess JH, Reinecker HC. Dendritic cells: the commanders-inchief of mucosal immune defenses. Curr Opin Gastroenterol 2006; 22: 354-360