Therapeutic effect of whole bear bile and its components against croton oil-induced rectal inflammation in rats

Biomolecules and Therapeutics

Volumn 18, Issue 1, 2010, Pages 83-91

  Park, Jeong Sook ^a   Yoo, Dong Ho ^a   Lee, In Jeong ^a   Roh, Eunmiri ^a   Kim, Youngsoo ^a   Han, Kun ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Bear bile; CDCA; Inflammation; iNOS; NO; UDCA

Indexed keywords

ANTIINFLAMMATORY AGENT; BILE ACID; CHENODEOXYCHOLIC ACID; CROTON OIL; IBUPROFEN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; URSODEOXYCHOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BILE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; PROCTITIS; RAT; RECTUM; SPRAGUE DAWLEY RAT; THERAPY EFFECT; THICKNESS; WHOLE BEAR BILE;

GOSSYPIUM HIRSUTUM; RATTUS;

EID: 76749127011     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2010.18.1.083     Document Type: Article

References (18)

1. Archer, S. (1993). Measurement of nitric oxide in biological models. FASEB J. 7, 349-360.
2. Beuers, U., Boyer, J. L. and Paumgartner, G. (1998). Ursode-oxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications. Hepatology 28, 1449-1453.
3. Earnest, D. L., Holubec, H., Wali, R. K., Jolley, C. S., Bissonette, M., Bhattacharyya, A. K., Roy, H., Khare, S. and Brasitus, T. A. (1994). Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 54, 5071-5074.
4. Fried, R. H., Murakami, C. S., Fisher, L. D., Willson, R. A., Sullivan, K. M. and McDonald, G. B. (1992). Ursodeoxy-cholic acid treatment of refractory chronic graft-versus-host disease of the liver. Ann. Intern. Med. 116, 624-629.
5. Hattori, Y., Murakami, Y., Hattori, S., Kuroda, H., Kasai, K. and Shimoda, S. (1996). Ursodeoxycholic acid inhibits the induction of nitric oxide synthase. Eur. J. Pharmacol. 300, 147-150.
6. Invernizzi, P., Salzman, A. L., Szabo, C., Ueta, I., O'Connor, M. and Setchell, K. D. (1997). Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo. Am. J. Physiol. 273, G131-G138.
7. Katsuyama, K., Shichiri, M., Kato, H., Imai, T., Marumo, F. and Hirata, Y. (1999). Differential inhibitory actions by glucocorticoid and aspirin on cytokine-induced nitric oxide production in vascular smooth muscle cells. Endocrinology 140, 2183-2190.
8. Korhonen, R., Lahti, A., Kankaanranta, H. and Moilanen, E. (2005). Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy 4, 471-479.
9. Loder, P. B., Kamm, M. A., Nicholls R. J. and Phillips, R. K. (1994). Hemorrhoids: pathology, pathophysiology and aetiology. Br. J. Surg. 81, 946-954.
10. Milsom, J. W. (1992). Hemorrhoidal disease. In Fundamentals of Anorectal Surgery (D. E. Beck, S. D. Wexner, Eds), pp. 192-214. McGraw-Hill, New York.
11. Mingrone, G. and Greco, A. V. (1980). Reversed phase high performance liquid chromatographic separation and quantification of individual human bile acids. J. Chromatogr. 183, 277-286.
12. Needleman, P. and Isakson, P. C. (1997). The discovery and function of COX-2. J. Rheumatol. 49, 6-8.
13. Podda, M., Ghezzi, C., Battezzati, P. M., Crosignani, A., Zuin, M. and Roda, A. (1990). Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 98, 1044-1050.
14. Poupon, R. E., Poupon, R. and Balkau, B. (1994). Ursodiol for the long-term treatment of primary biliary cirrhosis. N. Engl. J. Med. 330, 1342-1347.
15. Seybold, V. S., Jia, Y. P. and Abrahams, L. G. (2003). Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation. Pain 105, 47-55.
16. Solá, S., Garshelis, D. L., Amaral, J. D., Noyce, K. V., Coy, P. L., Steer, C. J., Iaizzo, P. A. and Rodrigues, C. M. (2006). Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes. Comp. Biochem. Physiol. 143, 204-208.
17. Tanaka, H., Makino, Y., Miura, T., Hirano, F., Okamoto, K., Komuro, K., Sato, Y. and Makino I. (1990). Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of INF-γ-induced MHC class II gene expression via a glucocorticoid receptor dependent pathway. J. Immunol. 156, 1601-1608.
18. Weitzel, C., Stark, D., Kullmann, F., Schölmerich, J., Holstege, A. and Falk, W. (2005). Ursodeoxycholic acid induced activation of the glucocorticoid receptor in primary rat hepatocytes. Eur. J. Gastroenterol. Hepatol. 17, 169-177.