Ursodeoxycholic acid inhibits the induction of nitric oxide synthase

European Journal of Pharmacology

Volumn 300, Issue 1-2, 1996, Pages 147-150

  Hattori, Yoshiyuki ^a   Murakami, Yasuyuki ^a   Hattori, Sachiko ^a   Kuroda, Hisamoto ^a   Kasai, Kikuo ^a   Shimoda, Shin Ichi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

J774 macrophage; Lipopolysaccharide; Nitric oxide (NO) synthase; Ursodeoxycholic acid

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; URSODEOXYCHOLIC ACID;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INDUCTION; ETIOLOGY; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL;

EID: 0029996310     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00012-X     Document Type: Article

References (17)

1. Cheley, S. and R. Anderson, 1984, A reproducible microanalytical method for the detection of specific RNA sequences by dot-blot hybridization, Anal. Biochem. 137, 15.
2. Farrell, A.J., D.R. Blake, R.M.J. Palmer and S. Moncada, 1992, Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases, Ann. Rheum. Dis. 51, 1219.
3. Fedorowski, T., G. Salen, A. Colallilo, G.S. Tint, E.H. Mosbach and J.C. Hall, 1977, Metabolism of ursodeoxycholic acid in man, Gastroenterology 73, 1131.
4. Hattori, Y. and S.S. Gross, 1993, GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase, Biochem. Biophys. Res. Commun. 195, 435.
5. Hattori, S., Y. Hattori, N. Banba, K. Kasai and S. Shimoda, 1995, Pentamethyl-hydroxychromane, vitamin E derivative, inhibits induction of nitric oxide synthase by bacterial lipopolysacccharide, Biochem. Mol. Biol. Int. 35, 177.
6. Kolb, H. and V. Kolb-Bachofen, 1992, Type 1 (insulin-dependent) diabetes mellitus and nitric oxide, Diabetologia 35, 796.
7. Lacaille, F. and K. Paradis, 1993, The immunosuppressive effect of ursodeoxycholic acid: comparative in vitro study on human peripheral blood mononuclear cells, Hepatology 18, 165.
8. Lyons, C.R., G.J. Orloff and J.M. Cunningham, 1992, Molecular cloning and expression of an inducible nitric oxide synthase from a murine macrophage cell line, J. Biol. Chem. 267, 6370.
9. Mosmann, T., 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J. Immunol. Methods 65, 55.
10. Nathan, C., 1992, Nitric oxide as a secretory product of mammalian cells, FASEB J. 6, 3051.
11. Poupon, R.E., R. Poupon, B. Balkau and the UDCA-PBC study group, 1994, Ursodiol for the long-term treatment of primary biliary cirrhosis, New Engl. J. Med. 330, 1342.
12. Sakurai, H., H. Kohsaka, M.F. Liu, H. Higashiyama, Y. Hirata, K. Kanno, I. Saito and N. Miyasaka, 1995, Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides, J. Clin. Invest. 96, 2357.
13. Szabo, C., C.C. Wu, C. Thiemermann and J.R. Vane, 1993, Interleukin-1 contribute to the induction of nitric oxide synthase by endotoxin in vivo, Eur. J. Pharmacol. 250, 157.
14. Terada, Y., K. Tomita, H. Nonoguchi and F. Marumo, 1992, Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments, J. Clin. Invest. 90, 659.
15. Thiemermann, C., C.C. Wu, C. Szabo, M. Perretti and J.R. Vane, 1993, Role of tumour necrosis factor in the induction of nitric oxidesynthase in a rat model of endotoxin shock, Br. J. Pharmacol. 110, 177.
16. G-monomethyl-L-arginine, J. Exp. Med. 179, 651.
17. Yoshikawa, M., T. Tsuji, K. Matsumura, J. Yamao, Y, Matsumura, R. Kubo, H. Fukui and S. Ishizaki, 1992, Immunomodulatory effects of ursodeoxycholic acid on immune responses, Hepatology 16, 358.