Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Oral Oncology

Volumn 46, Issue 3, 2010, Pages 154-157

  Dong, Zuoqing ^a   Liu, Shaohua ^a   Zhou, Chengjun ^b   sumida, Tomoki ^c   Hamakawa, Hiroyuki ^c   Chen, Zhenggang ^a   Liu, Pei ^a   Wei, Fengcai ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Id 1; Oral squamous cell carcinoma; Prognosis

Indexed keywords

INHIBITOR OF DIFFERENTIATION 1;

ADULT; ANGIOGENESIS; ARTICLE; CANCER STAGING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MOUTH CARCINOMA; ORAL SQUAMOUS CELL CARCINOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR RECURRENCE; TUMOR VOLUME;

CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITOR OF DIFFERENTIATION PROTEIN 1; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; RISK FACTORS; TREATMENT OUTCOME; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 76749102880     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2009.11.005     Document Type: Article

References (17)

1. Benezra R., Davis R.L., Lockshon D., Turner D.L., and Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61 1 (1990) 49-59
2. Kadesch T. Consequences of heteromeric interactions among helix-loop-helix proteins. Cell Growth Differ 4 1 (1993) 49-55
3. Norton J.D., Deed R.W., Craggs G., and Sablitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 8 2 (1998) 58-65
4. Benezra R., Rafii S., and Lyden D. The Id proteins and angiogenesis. Oncogene 20 58 (2001) 8334-8341
5. Norton J.D., and Atherton G.T. Coupling of cell growth control and apoptosis functions of Id proteins. Mol Cell Biol 18 4 (1998) 2371-2381
6. Lasorella A., Uo T., and Iavarone A. Id proteins at the cross-road of development and cancer. Oncogene 20 58 (2001) 8326-8333
7. Lyden D., Young A.Z., Zagzag D., Yan W., Gerald W., O'Reilly R., et al. Id-1 and Id-3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401 6754 (1999) 670-677
8. Schoppmann S.F., Schindl M., Bayer G., Aumayr K., Dienes J., Horvat R., et al. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int J Cancer 104 6 (2003) 677-682
9. Ouyang X.S., Wang X., Lee D.T., Tsao S.W., and Wong Y.C. Over expression of Id-1 in prostate cancer. J Urol 167 6 (2002) 2598-2602
10. Langlands K., Down G.A., and Kealey T. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 60 21 (2000) 5929-5933
11. Nishimine M., Nakamura M., Mishima K., Kishi M., Kirita T., Sugimura M., et al. Id proteins are overexpressed in human oral squamous cell carcinomas. J Oral Pathol Med 32 6 (2003) 350-357
12. Ling M.T., Lau T.C., Zhou C., Chua C.W., Kwok W.K., Wang Q., et al. Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis 26 10 (2005) 1668-1676
13. Hansen S., Grabau D.A., Rose C., Bak M., and Sørensen F.B. Angiogenesis in breast cancer: a comparative study of the observer variability of methods for determining microvessel density. Lab Invest 78 12 (1998) 1563-1573
14. Deed R.W., Armitage S., and Norton J.D. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J Biol Chem 271 39 (1996) 23603-23606
15. Yuen H.F., Chan Y.P., Chan K.K., Chu Y.Y., Wong M.L., Law S.Y., et al. Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer 97 10 (2007) 1409-1415
16. Meteoglu I., Meydan N., and Erkus M. Id-1: regulator of EGFR and VEGF and potential target for colorectal cancer therapy. J Exp Clin Cancer Res 27 (2008) 69
17. Schindl M., Schoppmann S.F., Ströbel T., Heinzl H., Leisser C., Horvat R., et al. Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin Cancer Res 9 2 (2003) 779-785