Home orthostatic training in vasovagal syncope modifies autonomic tone: Results of a randomized, placebo-controlled pilot study

Europace

Volumn 12, Issue 2, 2010, Pages 240-246

  Tan, Maw Pin ^a   Newton, Julia L ^a,b   Chadwick, Tom J ^a   Gray, Janine C ^b   Nath, Samiran ^c   Parry, Steve W ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ROYAL VICTORIA INFIRMARY   (United Kingdom)

^c NORTH TYNESIDE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Autonomic nervous system; Baroreflex sensitivity; Heart rate variability; Tilt training; Vasovagal syncope

Indexed keywords

ADULT; AGED; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART RATE VARIABILITY; HEMODYNAMICS; HOME CARE; HOME ORTHOSTATIC TRAINING; HUMAN; MALE; PILOT STUDY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHAM PROCEDURE; SYNCOPE; TILT TABLE TEST; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; DIZZINESS; FEASIBILITY STUDIES; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; MONITORING, AMBULATORY; PATIENT COMPLIANCE; PILOT PROJECTS; POSTURAL BALANCE; SYNCOPE, VASOVAGAL; TILT-TABLE TEST; TREATMENT OUTCOME; YOUNG ADULT;

EID: 76749102572     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/eup368     Document Type: Article

References (30)

1. Brignole M, Menozzi C, Bartoletti A, Giada F, Lagi A, Ungar A et al. A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals. Eur Heart J 2006;27:76-82.
2. Kenny RA, Ingram A, Bayliss J, Sutton R. Head-up tilt: a useful test for investigating unexplained syncope. Lancet 1986;1:1352-1355
3. Tan MP, Parry SW. Vasovagal syncope in the older patient. J Am Coll Cardiol 2008; 51:599-606.
4. Sheldon R, Connolly S, Rose S, Klingenheben T, Krahn A, Morillo C et al. Prevention of syncope trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope. Circulation 2006;113:1164-1170
5. Connolly SJ, Sheldon R, Thorpe KE, Roberts RS, Ellenbogen KA, Wilkoff BL et al. Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: second vasovagal pacemaker study (VPS II): a randomized trial. JAMA 2003;289:2224-2229
6. Raviele A, Giada F, Menozzi C, Speca G, Orazi S, Gasparini G et al. A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE). Eur Heart J 2004;25:1741-1748
7. Abe H, Kondo S, Kohshi K, Nakashima Y. Usefulness of orthostatic self-training for the prevention of neurocardiogenic syncope. Pacing Clin Electrophysiol 2002; 25:1454-1458
8. Di Girolamo E, Di Iorio C, Leonzio L, Sabatini P, Barsotti A. Usefulness of a tilt training program for the prevention of refractory neurocardiogenic syncope in adolescents: a controlled study. Circulation 1999;100:1798-1801
9. Kinay O, Yazici M, Nazli C, Acar G, Gedikli O, Altinbas A et al. Tilt training for recurrent neurocardiogenic syncope: effectiveness, patient compliance, and scheduling the frequency of training sessions. Jpn Heart J 2004;45:833-843
10. Lafuente EA, Martinez LC, Moguel JO, David RN, Garcia JD, Tejeda AO et al. Response to treatment during medium-term follow-up in a series of patients with neurocardiogenic syncope. Arch Med Res 2004;35:416-420
11. Reybrouck T, Heidbuchel H, Van De Werf F, Ector H. Long-term follow-up results of tilt training therapy in patients with recurrent neurocardiogenic syncope. Pacing Clin Electrophysiol 2002;25:1441-1446
12. Verheyden B, Ector H, Aubert AE, Reybrouck T. Tilt training increases the vasoconstrictor reserve in patients with neurally mediated syncope evoked by head-up tilt testing. Eur Heart J 2008;29:1523-1530
13. Foglia-Manzillo G, Giada F, Gaggioli G, Bartoletti A, Lolli G, Dinelli M et al. Efficacy of tilt training in the treatment of neurally mediated syncope. A randomized study. Europace 2004;6:199-204.
14. On YK, Park J, Huh J, Kim JS. Is home orthostatic self-training effective in preventing neurally mediated syncope? Pacing Clin Electrophysiol 2007;30:638-643
15. Duygu H, Zoghi M, Turk U, Akyuz S, Ozerkan F, Akilli A et al. The role of tilt training in preventing recurrent syncope in patients with vasovagal syncope: a prospective and randomized study. Pacing Clin Electrophysiol 2008;31:592-596
16. Gurevitz O, Barsheshet A, Bar-Lev D, Zimlichman E, Rosenfeld GF, Benderly M et al. Tilt training: does it have a role in preventing vasovagal syncope? Pacing Clin Electrophysiol 2007;30:1499-1505
17. Brignole M, Alboni P, Benditt DG, Bergfeldt L, Blanc JJ, Bloch Thomsen PE et al. Guidelines on management (diagnosis and treatment) of syncope-update 2004. Europace 2004;6:467-537.
18. Parry SW, Reeve P, Lawson J, Shaw FE, Davison J, Norton M et al. The Newcastle protocols 2008: an update on head-up tilt table testing and the management of vasovagal syncope and related disorders. Heart 2009;95:416-420
19. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996;93: 1043-1065
20. Steptoe A, Vogele C. Cardiac baroreflex function during postural change assessed using non-invasive spontaneous sequence analysis in young men. Cardiovasc Res 1990;24:627-632
21. Ewing DJ, Clarke BF. Diagnosis and management of diabetic autonomic neuropathy. Br Med J Clin Res Ed 1982;285:916-918
22. Parati G, Di Rienzo M, Bertinieri G, Pomidossi G, Casadei R, Groppelli A et al. Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 1988;12:214-222
23. Piccirillo G, Magri D, Di Carlo S, Matera S, Magnanti M, De Laurentis T et al. Power spectral analysis of heart rate variability as a predictive test in choosing the most effective length for tilt-training. Int J Cardiol 2006;111:59-66.
24. Gajek J, Zysko D, Halawa B, Mazurek W. Influence of tilt training on activation of the autonomic nervous system in patients with vasovagal syncope. Acta Cardiol 2006;61:123-128
25. Bechir M, Binggeli C, Corti R, Chenevard R, Spieker L, Ruschitzka F et al. Dysfunctional baroreflex regulation of sympathetic nerve activity in patients with vasovagal syncope. Circulation 2003;107:1620-1625
26. Thomson HL, Wright K, Frenneaux M. Baroreflex sensitivity in patients with vasovagal syncope. Circulation 1997;95:395-400.
27. Piccirillo G, Naso C, Moise A, Lionetti M, Nocco M, Di Carlo S et al. Heart rate and blood pressure variability in subjects with vasovagal syncope. Clin Sci 2004; 107:55-61.
28. Jardine DL, Ikram H, Frampton CM, Frethey R, Bennett SI, Crozier IG. Autonomic control of vasovagal syncope. Am J Physiol 1998;274:H2110-5.
29. Blaber AP, Bondar RL, Kassam MS. Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance. BMC Physiol 2004; 4:6.
30. Moya A, Permanyer-Miralda G, Sagrista-Sauleda J, Carne X, Rius T, Mont L et al. Limitations of head-up tilt test for evaluating the efficacy of therapeutic interventions in patients with vasovagal syncope: results of a controlled study of etilefrine versus placebo. J Am Coll Cardiol 1995;25:65-69