A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells

Blood

Volumn 95, Issue 6, 2000, Pages 1957-1966

  Shih, Chu Chih ^a   Hu, Mickey C T ^b   Hu, Jun ^b   Weng, Yehua ^b   Yazaki, Paul J ^b   Medeiros, Jeffrey ^b   Forman, Stephen J ^b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; STEM CELL FACTOR; THROMBOPOIETIN;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE THERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SCID MOUSE; STEM CELL TRANSPLANTATION; STROMA CELL;

EID: 0034653997     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.6.1957     Document Type: Article

References (64)

1. Scheding S, Kratz-Albers K, Meiser B, Brugger W, Kanz L. Ex vivo expansion of hematopoietic progenitor cells for clinical use. Semin Hematol. 1998;35:232.
2. von Kalle C, Glimm H, Schulz G, Mertelsmann R, Henschlker R. New developments in hematopoietic stem cell expansion. Curr Opin Hematol. 1998;5:79.
3. Conrad PD, Emerson SG. Ex vivo expansion of hematopoietic cells from umbilical cord blood for clinical transplantation. J Leukoc Biol. 1998;64: 147.
4. Laluppa JA, Papousakis ET, Miller WM. Ex vivo expansion of hematopoietic stem and progenitor cells for transplantation. Cancer Treat Res. 1997; 77:159.
5. Lu L, Shen RN, Broxmeyer HE. Stem cells from bone marrow, umbilical cord blood and peripheral blood for clinical application: current status and future application. Crit Rev Oncol Hematol. 1996; 22:61.
6. Kurtzberg J, Laughlin M, Graham M, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;35:157.
7. Wagner J, Rosenthal J, Sweetman R, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors; analysis of engraflment and acute graft-versus-host disease. Blood. 1996;88:795.
8. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord blood transplantation from unrelated and related donors. N Engl J Med. 1997; 337:373.
9. Shih C-C, Hu MC-T, Hu J, Medeiros J, Forman SJ. Long-term ex vivo maintenance and expansion of transplantable human hematopoietic stem cells. Blood. 1999;94:1623.
10. Hilton DJ, Gough NM. Leukemia inhibitory factor: a biological perspective. J Cell Biochem. 1991; 46:21.
11. Whitlock CA, Tidmarsh GF, Muller-Sieburg C, Weissman IL. Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule. Cell. 1987; 48:1009.
12. Terstappen LWMM, Huang S, Safford M, Lansdorp PM, Loken MR. Sequential generations of hematopoietic colonies derived from single non-lineage-committed CD34+CD38- progenitor cells. Blood. 1991;77:1218.
13. Huang S, Terstappen LWMM. Lymphoid and myeloid differentiation of single human CD34+, HLA-DR+, CD38- hematopoietic stem cells. Blood. 1994;83:1515.
14. Lyman SD, James L, Vanden Bos T, et al. Molecular cloning of a ligand for the flt3/flk2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell, 1993;75:1157.
15. Lyman SD, James L, Johnson L, et al. Cloning of human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. Blood. 1994;83:2795.
16. de Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopolesis and thrombopoiesis by the c-mpl ligand. Nature. 1994;369: 533.
17. Kaushansky K, Lok S, Holly RD, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature. 1994;369:369.
18. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood. 1995;86: 419.
19. Harris ELV. Concentration of the extract. In: Harris ELV, Angal S, eds. Protein Purification Methods: A Practical Approach. New York, IRL Press at Oxford University Press; 1989:125.
20. Brattsand M, Egelrud T. Purification and characterization of interleukin 1b from human plantar stratum corneum: evidence of interleukin 1b processing in vivo not involving interleukin 1b convertase. Cytokines. 1998;10:506.
21. Baum CM, Weissman IL, Tsukamoto AS, Buckle A, Peault B. Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci U S A. 1992;89:2804.
22. Chen BP, Galy A, Kyoizumi S, et al. Engraftment of human hematopoietic precursor cells with secondary transfer potential in SCID-hu mice. Blood. 1994;84:2497.
23. Szilvassy SJ, Weller KP, Lin W, et al. Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood. 1996;87:4618.
24. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 1991;65:1143.
25. Rosnet O, Schiff C, Pebusque M, et al. Human FLT3/FLK2 gene: cDN A cloning and expression in hematopoietic cells. Blood. 1993;82:1110.
26. Zeigler FC, Bennet BD, Jordan CT, et al. Cellular and molecular characterization of the role of the FLK2/FLT3 receptor tyrosine kinase in hematopoietic stem cells. Blood. 1994;84:2422.
27. Small D, Levenstein M, Kim E, et al. STK-1, the human homologue of flk-2/flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A. 1994;91: 459.
28. Hudak S, Hunte B, Culpepper J, et al. FLT3/FLK2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units. Blood. 1995; 85:2747.
29. Jacobsen SEW, Okkenhaug C, Myklebust J, Veiby OP, Lyman SD. The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. J Exp Med. 1995;181:1357.
30. Hirayama F, Lyman SD, Clark SC, Ogawa M. The flt3 ligand supports proliferation of lymphohematopoietic progenitors and early B-lymphoid progenitors. Blood. 1995;85:1762.
31. McKenna HJ, de Vries P, Brasel K, Lyman SD, Williams DE. Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells. Blood. 1995;86:3413.
32. Brasel K, McKenna HJ, Morrissey PJ, et al. Hematopoietic effects of flt3 ligand in vivo in mice. Blood. 1996;88:2004.
33. Neipp M, Zorina T, Domenick MA, Exner BG, Ildstad ST. Effect of FLT3 ligand and granulocyte colony-stimulating factor on expansion and mobilization of facilitating cells and hematopoietic stem cells in mice: kinetics and repopulating potential. Blood. 1998;92:3177.
34. Pless M, Wodnar-Filipowicz A, John L, et al. Synergy of growth factors during mobilization of peripheral blood precursor cells with recombinant human Flt3-ligand and granulocyte colony-stimulating factor in rabbits. Exp Hematol. 1999;27: 155.
35. Shah AJ, Smogorzewska EM, Hannum C, Crooks GM. Flt3 ligand induces proliferation of quiescent human bone marrow CD34+ CD38 - cells and maintains progenitor cells in vitro. Blood. 1996; 87:3563.
36. Ramsfjell V, Borge OJ, Veiby OP, et al. Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Blood. 1996;88:4481.
37. Sitnicka E, Lin N, Priestley GV, et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood. 1996;87:4998.
38. Yagi M, Ritchie KA, Sitnicka E, Storey C, Roth GJ, Bartelmez S. Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proc Natl Acad Sci U S A. 1999;96:8126.
39. Young JC, Lin K, Hansteen G, et al. CD34+ cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the thy-1+ subset following cell division ex vivo. Exp Hematol. 1999;27:994.
40. Murray LJ, Young JC, Osborne LJ, Leuns KM, Scollay R, Hill BL. Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ thy-1+ cells into rapid division. Exp Hematol. 1999;27:1019.
41. Young JC, Bruno E, Luens KM, Wu S, Backer M, Murray L. Thrombopoielin stimulates megakaryocytopoiesis, myelopoiesis and expansion of primitive CD34+ progenitor cells from single CD34+ thy-1+ Lin- primitive progenitor cells. Blood. 1996;88:1619.
42. Grossmann A, Lenox J, Ren HP, et al. Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice. Exp Hematol. 1996;24:1238.
43. Kimura S, Roberts AW, Metcalf D, Alexander WS. Hematopoietic stem cell deficiencies in mice lacking c-mpl, the receptor for thrombopoietin. Proc Natl Acad Sci U S A. 1998;95:1195.
44. Murone M, Carpenter DA, de Sauvage FJ. Hematopoietic deficiencies in c-mpl and TPO knockout mice. Stem Cells. 1998;16:1.
45. Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of hematopoietic stem cells in vitro. J Cell Physiol. 1977;91:335.
46. Weilbaecher K, Weissman IL, Blume K, Heimfeld S. Culture of phenotypically defined hematopoietic stem cells and other progenitors at limiting dilution on Dexter monolayers. Blood. 1991;78: 945.
47. Fraser CC, Szilvassy SJ, Eaves CJ, Humphries RK. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive reconstituting ability. Proc Natl Acad Sci U S A. 1992;89:1968.
48. Wineman J, Moore K, Lemischka I, Muller-Sieburg C. Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells. Blood. 1996;87:4082.
49. Collins LS, Dorshkind K. A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis. J Immunol. 1987;138:1082.
50. Deryugina El, Ratnikov BI, Bourdon MA, Muller-Sieburg CE. Clonal analysis of primary marrow stroma: functional homogeneity in support of lymphoid and myeloid cell lines and identification of positive and negative regulators. Exp Hematol. 1994;22:910.
51. Thiemann FT, Moore KA, Smogorzewska L, Lemischka IR, Crooks GM. The murine stromal cell line AFT024 acts specifically on human CD34+ CD38- progenitors to maintain primitive function and immunophenotype in vitro. Exp Hematol. 1998;26:612.
52. Neben S, Anklesaria P, Greenberger J, Mauch P. Quantitation of murine hematopoietic stem cells in vitro by limiting dilution analysis of cobblestone area formation on a clonal stromal cell line. Exp Hematol. 1993;21:438.
53. Uchida N, Fleming WH, Alpern EJ, Weissman IL. Heterogeneity of hematopoietic stem cells. Curr Opin Immunol. 1993;5:177.
54. Aiuti A, Friedrich C, Sieff CA, Gutierrez-Ramos JC. Identification of distinct elements of the stromal microenvironment that control human hematopoietic stem/progenitor cell growth and differentiation. Exp Hematol. 1998;26:143.
55. Mielcarek M, Reems J, Torok-Storb B. Extrinsic control of stem cell fate: practical considerations. Stem Cells. 1997;15(suppl 1):229.
56. Metcalf D. Leukemia inhibitory factor: a puzzling polyfunctional regulator. Growth Factors. 1992;7: 169.
57. Gearing DP. The leukemia inhibitory factor and its receptor. Adv Immunol. 1993;53:31.
58. Metcalf D, Hilton P, Nicola NA. Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro. Blood. 1991;77:2150.
59. Escary J-L, Perreau J, Dumenil D, Ezine S, Brulet P. Leukemia inhibitory factor is necessary for maintenance of hematopoietic stem cells and thymocyte stimulation. Nature. 1993;363:361.
60. Fletcher F, Williams D, Maliszewski C, Anderson D, Rives M, Belmont J. Murine inhibitory factor enhances retroviral-infection efficiency of hematopoietic progenitors. Blood. 1990;76: 1098.
61. Keller JR, Gooya JM, Ruscetti FW. Direct synergistic effects of leukemia inhibitory factor on hematopoietic progenitor cell growth: comparison with other hematopoietins that use the gp130 receptor subunit. Blood. 1996;88:863.
62. Borge OJ, Ramsfjell V, Veiby OP, Murphy MJ, Lok S, Jacobsen SEW. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood. 1996;88:2859.
63. Borge OJ, Ramsfjell V, Cui L, Jacobsen SEW. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+ CD38 bone marrow cells with multilineage potential at single cell level: key role of thrombopoietin. Blood. 1997;90:2282.
64. Keller JR, Ortiz M, Ruscetti FW. Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division. Blood. 1995;86:1757.