Osmotic pumping release from ethyl-hydroxypropyl-cellulose-coated pellets: A new mechanistic model

Journal of Controlled Release

Volumn 142, Issue 1, 2010, Pages 53-60

  Marucci, Mariagrazia ^a   Ragnarsson, Gert ^b   Nilsson, Bernt ^a   Axelsson, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

^b MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Coating; Modelling; Multiple unit release; Osmotic pumping; Pellet; Release mechanism

Indexed keywords

BEFORE AND AFTER; COATING FILMS; COATING MODELLING; DRUG CONCENTRATION; DRUG RELEASE; ETHYL CELLULOSE; EXPERIMENTAL DATA; HYDROXYPROPYL CELLULOSE; MAIN PROCESS; MASS ACCUMULATIONS; MECHANISTIC MODELS; METOPROLOL; OSMOTIC PRESSURE; PRESSURE BUILD UP; RELEASE EXPERIMENTS; RELEASE MECHANISM; RELEASE PROCESS; RELEASE PROFILES; WATER SOLUBLE COMPOUNDS;

CELLULOSE; DIFFUSION COATINGS; DISSOLUTION; HYDROSTATIC PRESSURE; LEACHING; ORE PELLETS; PELLETIZING; PUMPS; SCANNING ELECTRON MICROSCOPY;

OSMOSIS;

ETHYL CELLULOSE; HYDROXYPROPYLCELLULOSE; METOPROLOL SUCCINATE;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG PELLET; DRUG RELEASE; DRUG SOLUBILITY; FILM COATING; HYDROSTATIC PRESSURE; LEACHING; OSMOTIC PRESSURE; OSMOTIC PUMP; PERMEABILITY; PHYSICAL CHEMISTRY; POROSITY; PREDICTION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; VALIDATION PROCESS;

ADRENERGIC BETA-ANTAGONISTS; CELLULOSE; DIFFUSION; DRUG IMPLANTS; METOPROLOL; MODELS, CHEMICAL; OSMOSIS; POROSITY;

CELLULOSE; COATING; DIFFUSION; DISSOLVING; HYDRAULIC PRESSURE; OSMOTIC PRESSURE; PELLETS; SCANNING ELECTRON MICROSCOPY;

EID: 76749098732     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.10.009     Document Type: Article

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