Mechanistic model for drug release during the lag phase from pellets coated with a semi-permeable membrane

Journal of Controlled Release

Volumn 127, Issue 1, 2008, Pages 31-40

  Marucci, Mariagrazia ^a   Ragnarsson, Gert ^b   Nyman, Ulf ^a   Axelsson, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

^b MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Diffusion; Modelling; Osmotic pumping; Swelling; Tensile stress

Indexed keywords

COMPUTER SIMULATION; DIFFUSION; HYDROSTATIC PRESSURE; MATHEMATICAL MODELS; SWELLING; TENSILE STRESS;

COATED PELLETS; OSMOTIC PUMPING; SEMIPERMEABLE MEMBRANE; SOLID MECHANICS THEORY; SOLVENT ACCUMULATION;

DRUG PRODUCTS;

ETHYL CELLULOSE; REMOXIPRIDE;

ARTICLE; COMPUTER SIMULATION; DRUG RELEASE; HYDROSTATIC PRESSURE; MATHEMATICAL ANALYSIS; OSMOTIC PRESSURE; PRIORITY JOURNAL; THERMODYNAMICS; WATER TRANSPORT;

DRUG CARRIERS; DRUG IMPLANTS; MEMBRANES, ARTIFICIAL; MODELS, THEORETICAL; OSMOTIC PRESSURE; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; REMOXIPRIDE; SOLUBILITY; TENSILE STRENGTH;

EID: 40649088816     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.12.003     Document Type: Article

References (24)

1. Schultz P., and Kleinebudde P. A new multiparticulate delayed release system. Part I: dissolution properties and release mechanism. J. Control. Release 47 (1997) 181-189
2. Schultz P., Tho I., and Kleinebudde P. A new multiparticulate delayed release system. Part II: coating formulation and properties of free films. J. Control. Release 47 (1997) 191-199
3. Marucci M., Ragnarsson G., and Axelsson A. Evaluation of osmotic effects on coated pellets using a mechanistic model. Int. J. Pharm. 336 2 (2007) 67-74
4. Hartman Kok P.J.A., Vonk P., Hoekzema M.A., and Kossen N.W.F. Development of particulate pulse-release formulations and their mathematical description. Powder Technol. 119 (2001) 33-44
5. Ueda S., Hata T., Asakura S., Yamaguchi H., Kotani M., and Ueda Y. Development of a novel drug release system, time controlled explosion system (TES): I. concept and design. J. Drug Target. 2 1 (1994) 35-44
6. Lu S.M., and Chen S.R. Controlled release from a coated particle - effects of initial conditions and methods of solution. Int. J. Pharm. 119 (1995) 11-23
7. Farrel S., and Sirkar K.K. A mathematical model of an aqueous-organic partition based controlled release system using microporous membranes. J. Control. Release 61 (1999) 345-360
8. Farrel S., and Sirkar K.K. Mathematical model of a hybrid dispersed network-membrane-based controlled release system. J. Control. Release 70 (2001) 51-61
9. Siepmann J., Lecomte F., and Bodmeier R. Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles. J. Control. Release 60 (1999) 379-389
10. Koizumi T., Ritthidej G.C., and Phaechamud T. Mechanistic modeling of drug release from chitosan coated tablets. J. Control. Release 70 (2001) 277-284
11. Frenning G., Tunon A., and Alderborn G. Modelling of drug release from coated granular pellets. J. Control. Release 92 1-2 (2003) 113-123
12. Sirotti C., Colombo I., and Grassi M. Modelling of drug-release from poly-disperse microencapsulated spherical particles. J. Microencapsul 19 5 (2002) 603-614
13. Haddish-Berhane N., Jeong S.H., Haghigi K., and Rark K. Modeling film-coat non-uniformity in polymer coated pellets: a stochastic approach. Int. J. Pharm. 332 (2006) 64-71
14. Borgquist P., Nevsten P., Nilsson B., Wallenberg L.R., and Axelsson A. Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments. J. Control. Release 97 3 (2004) 453-465
15. Borgquist P., Zackrisson G., Nilsson B., and Axelsson A. Simulation and parametric study of a film-coated controlled-release pharmaceutical. J. Control. Release 80 (2002) 229-245
16. Hartman Kok P.J.A., Vonk P., and Kossen N.W.F. A particulate pulse-release system and a mathematical description with the Maxwell-Stefan theory. J. Control. Release 66 (2000) 293-306
17. Siepmann J., Ainaoui A., Vergnaud J.M., and Bodmeier R. Calculation of the dimensions of drug-polymer devices based on diffusion parameters. J. Pharm. Sci. 87 7 (1998) 827-832
18. Liao Y.C., and Lee D.J. Slow release from a coated sphere with slight deformations of coating film and drug matrix. J. Pharm. Sci. 86 1 (1997) 92-100
19. Nevsten P., Borgquist P., Axelsson A., and Wallenberg L.R. XEDS-mapping for explaining release patterns from single-pellets. Int. J. Pharm. 290 (2005) 109-120
20. Mulder M. Basic Principle of Membrane Technology (1991), Kluwer Academic Publishers ed, Netherlands
21. Bird R.B., Stewart W.E., and Lightfoot E.N. Transport Phenomena. 2nd ed., (2002), John Wiley & Sons, New York
22. Timoshenko S., and Woinowsky-Krieger S. Theory of Plates and Shells (1959), McGraw-Hill
23. Process Systems Enterprise Ltd, gPROMS advanced user guide, Release 2.0-14 ed, Process Systems Enterprise Ltd, Bridge Studios, 107a Hammersmith Bridge Road, London W6 9DA, United Kingdom,2001.
24. Hjärtstam J., and Hjertberg T. Swelling of pellets coated with a composite film containing ethyl cellulose and hydroxypropyl methylcellulose. Int. J. Pharm. 161 1 (1998) 23-28