Putative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 2, 2010, Pages 650-658

  Hong, Mei ^a   Li, Shanshan ^a   Zhou, Fanfan ^a   Thomas, Paul E ^a   You, Guofeng ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; LEUCINE; ORGANIC ANION TRANSPORTER 1; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN COS7; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; LLC-PK1 CELLS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; ORGANIC ANION TRANSPORT PROTEIN 1; SWINE; TRANSFECTION;

EID: 76749095845     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.160515     Document Type: Article

References (31)

1. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, and Iwata S (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610-615.
2. Anzai N, Kanai Y, and Endou H (2006) Organic anion transporter family: current knowledge. J Pharmacol Sci 100:411-426.
3. Bahn A, Ebbinghaus C, Ebbinghaus D, Ponimaskin EG, Fuzesï L, Burckhardt G, and Hagos Y (2004) Expression studies and functional characterization of renal human organic anion transporter 1 isoforms. Drug Metab Dispos 32:424-430.
4. Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, and Burckhardt G (2008) Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 283:16332-16341.
5. Bauman PA and Blakely RD (2002) Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. Arch Biochem Biophys 404:80-91.
6. Bello V, Goding JW, Greengrass V, Sali A, Dubljevic V, Lenoir C, Trugnan G, and Maurice M (2001) Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis. Mol Biol Cell 12:3004-3015.
7. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, and Endou H (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275:4507-4512.
8. Eckhardt ER, Cai L, Shetty S, Zhao Z, Szanto A, Webb NR, and Van der Westhuyzen DR (2006) High density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif. J Biol Chem 281:4348-4353.
9. El-Sheikh AA, Masereeuw R, and Russel FG (2008) Mechanisms of renal anionic drug transport. Eur J Pharmacol 585:245-255.
10. Hong M, Zhou F, and You G (2004) Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J Biol Chem 279:31478-31482.
11. Huang Y, Lemieux MJ, Song J, Auer M, and Wang DN (2003) Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301:616-620.
12. Jensen TJ, Loo MA, Pind S, Williams DB, Goldberg AL, and Riordan JR (1995) Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83:129-135.
13. Kopito RR (1997) ER quality control: the cytoplasmic connection. Cell 88:427-430.
14. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
15. Peña-Münzenmayer G, Catalán M, Cornejo I, Figueroa CD, Melvin JE, Niemeyer MI, Cid LP, and Sepúlveda FV (2005) Basolateral localization of native CIC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif. J Cell Sci 118:4243-4252.
16. Perry JL, Dembla-Rajpal N, Hall LA, and Pritchard JB (2006) A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem 281:38071- 38079.
17. Popp C, Gorboulev V, Müller TD, Gorbunov D, Shatskaya N, and Koepsell H (2005) Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol Pharmacol 67:1600-1611.
18. Schnabolk GW, Youngblood GL, and Sweet DH (2006) Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol 291:F314-F321.
19. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, and Endou H (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182.
20. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
21. Sepp-Lorenzino L, Ma Z, Lebwohl DE, Vinitsky A, and Rosen N (1995) Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases. J Biol Chem 270:16580-16587.
22. Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, and Kanai Y (2007) Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 45:1046-1055.
23. Srimaroeng C, Perry JL, and Pritchard JB (2008) Physiology, structure, and regulation of the cloned organic anion transporters. Xenobiotica 38:889-935.
24. Sweet DH, Wolff NA, and Pritchard JB (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095.
25. Tanaka K, Xu W, Zhou F, and You G (2004) Role of glycosylation in the organic anion transporter OAT1. J Biol Chem 279:14961-14966.
26. Ward CL, Omura S, and Kopito RR (1995) Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83:121-127.
27. Yokoyama H, Anzai N, Ljubojevic M, Ohtsu N, Sakata T, Miyazaki H, Nonoguchi H, Islam R, Onozato M, Tojo A, et al. (2008) Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct. Cell Physiol Biochem 21:269-278.
28. You G (2004) The role of organic ion transporters in drug disposition: an update. Curr Drug Metab 5:55-62.
29. Youngblood GL and Sweet DH (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 287:F236-F244.
30. Zhang X, Shirahatti NV, Mahadevan D, and Wright SH (2005) A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2). J Biol Chem 280:34813-34822.
31. Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, and You G (2005) The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol Pharmacol 67:868-876.