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Volumn 50, Issue 2, 2010, Pages 101-108

Pain in multiple sclerosis: Prevalence, mechanisms, types and treatment;El dolor en la esclerosis múltiple: Prevalencia, mecanismos, tipos y tratamiento

Author keywords

Cannabinoids; Headache; L'hermitte's sign; Multiple sclerosis; Optic neuritis; Pain; Trigeminal neuralgia

Indexed keywords

ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BACLOFEN; BOTULINUM TOXIN A; CANNABIDIOL; DRONABINOL; OPIATE; TRIPTAN DERIVATIVE;

EID: 76749087611     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.5002.2008613     Document Type: Review
Times cited : (30)

References (62)
  • 1
    • 38849085875 scopus 로고    scopus 로고
    • The accuracy of prevalence rates of multiple sclerosis: A critical review
    • Poser CM, Brinar VV. The accuracy of prevalence rates of multiple sclerosis: a critical review. Neuroepidemiology 2007; 29: 150-5.
    • (2007) Neuroepidemiology , vol.29 , pp. 150-155
    • Poser, C.M.1    Brinar, V.V.2
  • 2
    • 15244350642 scopus 로고    scopus 로고
    • Sensory function and quality of life in patients with multiple sclerosis and pain
    • Svendsen KB, Jensen TS, Hansen HJ, Bach FW. Sensory function and quality of life in patients with multiple sclerosis and pain. Pain 2005; 114: 473-81.
    • (2005) Pain , vol.114 , pp. 473-481
    • Svendsen, K.B.1    Jensen, T.S.2    Hansen, H.J.3    Bach, F.W.4
  • 4
    • 0029592178 scopus 로고
    • Acute and chronic pain syndromes in multiple sclerosis: A 5-year follow-up study
    • Stenager E, Knudsen L, Jensen K. Acute and chronic pain syndromes in multiple sclerosis: a 5-year follow-up study. Ital J Neurol Sci 1995; 16: 629-32.
    • (1995) Ital J Neurol Sci , vol.16 , pp. 629-632
    • Stenager, E.1    Knudsen, L.2    Jensen, K.3
  • 5
    • 0028183208 scopus 로고
    • Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients
    • Archibald CJ, McGrath PJ, Ritvo PG, Fisk JD, Bhan V, Maxner CE, et al. Pain prevalence, severity and impact in a clinic sample of multiple sclerosis patients. Pain 1994; 58: 89-93.
    • (1994) Pain , vol.58 , pp. 89-93
    • Archibald, C.J.1    McGrath, P.J.2    Ritvo, P.G.3    Fisk, J.D.4    Bhan, V.5    Maxner, C.E.6
  • 6
    • 20144381538 scopus 로고    scopus 로고
    • Severity of chronic pain and its relationship to quality of life in multiple sclerosis
    • Kalia LV, O'Connor PW. Severity of chronic pain and its relationship to quality of life in multiple sclerosis. Mult Scler 2005; 11: 322-7.
    • (2005) Mult Scler , vol.11 , pp. 322-327
    • Kalia, L.V.1    O'Connor, P.W.2
  • 7
    • 0025908749 scopus 로고
    • Acute and chronic pain syndromes in multiple sclerosis
    • Stenager E, Knudsen L, Jensen K. Acute and chronic pain syndromes in multiple sclerosis. Acta Neurol Scand 1991; 84: 197-200.
    • (1991) Acta Neurol Scand , vol.84 , pp. 197-200
    • Stenager, E.1    Knudsen, L.2    Jensen, K.3
  • 9
    • 33845641001 scopus 로고    scopus 로고
    • Persistent pain and uncomfortable sensations in persons with multiple sclerosis
    • Hadjimichael O, Kerns RD, Rizzo MA, Cutter G, Vollmer T. Persistent pain and uncomfortable sensations in persons with multiple sclerosis. Pain 2007; 127: 35-41.
    • (2007) Pain , vol.127 , pp. 35-41
    • Hadjimichael, O.1    Kerns, R.D.2    Rizzo, M.A.3    Cutter, G.4    Vollmer, T.5
  • 11
    • 33845657843 scopus 로고    scopus 로고
    • Psychosocial factors associated with pain intensity, pain-related interference, and psychological functioning in persons with multiple sclerosis and pain
    • Osborne TL, Jensen MP, Ehde DM, Hanley MA, Kraft G. Psychosocial factors associated with pain intensity, pain-related interference, and psychological functioning in persons with multiple sclerosis and pain. Pain 2007; 127: 52-62.
    • (2007) Pain , vol.127 , pp. 52-62
    • Osborne, T.L.1    Jensen, M.P.2    Ehde, D.M.3    Hanley, M.A.4    Kraft, G.5
  • 12
    • 0036017497 scopus 로고    scopus 로고
    • Pain in multiple sclerosis: A biopsychosocial perspective
    • Kerns RD, Kassirer M, Otis J. Pain in multiple sclerosis: a biopsychosocial perspective. J Rehabil Res Dev 2002; 39: 225-32.
    • (2002) J Rehabil Res Dev , vol.39 , pp. 225-232
    • Kerns, R.D.1    Kassirer, M.2    Otis, J.3
  • 13
    • 44849144424 scopus 로고    scopus 로고
    • Pain associated with multiple sclerosis: Systematic review and proposed classification
    • O'Connor AB, Schwid SR, Herrmann DN, Markman JD, Dworkin RH. Pain associated with multiple sclerosis: systematic review and proposed classification. Pain 2008; 137: 96-111.
    • (2008) Pain , vol.137 , pp. 96-111
    • O'Connor, A.B.1    Schwid, S.R.2    Herrmann, D.N.3    Markman, J.D.4    Dworkin, R.H.5
  • 14
    • 40549117895 scopus 로고    scopus 로고
    • Current management of pain associated with multiple sclerosis
    • Pöllmann W, Feneberg W. Current management of pain associated with multiple sclerosis. CNS Drugs 2008; 22: 291-324.
    • (2008) CNS Drugs , vol.22 , pp. 291-324
    • Pöllmann, W.1    Feneberg, W.2
  • 16
    • 24044506007 scopus 로고    scopus 로고
    • Central pain in multiple sclerosis -prevalence and clinical characteristics
    • Osterberg A, Boivie J, Thuomas KA. Central pain in multiple sclerosis -prevalence and clinical characteristics. Eur J Pain 2005; 9: 531-42.
    • (2005) Eur J Pain , vol.9 , pp. 531-542
    • Osterberg, A.1    Boivie, J.2    Thuomas, K.A.3
  • 18
    • 42249103225 scopus 로고    scopus 로고
    • Prevalence of complex regional pain syndrome in a cohort of multiple sclerosis patients
    • Schwartzman RJ, Gurusinghe C, Gracely E. Prevalence of complex regional pain syndrome in a cohort of multiple sclerosis patients. Pain Physician 2008; 11: 133-6.
    • (2008) Pain Physician , vol.11 , pp. 133-136
    • Schwartzman, R.J.1    Gurusinghe, C.2    Gracely, E.3
  • 19
    • 0029087706 scopus 로고
    • Trigeminal neuralgia in multiple sclerosis
    • Hooge JP, Redekop WK. Trigeminal neuralgia in multiple sclerosis. Neurology 1995; 45: 1294-6.
    • (1995) Neurology , vol.45 , pp. 1294-1296
    • Hooge, J.P.1    Redekop, W.K.2
  • 20
    • 22144478637 scopus 로고    scopus 로고
    • Reappraisal of Lhermitte's sign in multiple sclerosis
    • Al-Araji AH, Oger J. Reappraisal of Lhermitte's sign in multiple sclerosis. Mult Scler 2005; 11: 398-402.
    • (2005) Mult Scler , vol.11 , pp. 398-402
    • Al-Araji, A.H.1    Oger, J.2
  • 21
    • 0020070296 scopus 로고
    • Lhermitte's sign in multiple sclerosis: A clinical survey and review of the literature
    • Kanchandani R, Howe JG. Lhermitte's sign in multiple sclerosis: a clinical survey and review of the literature. J Neurol Neurosurg Psychiatry 1982; 45: 308-12.
    • (1982) J Neurol Neurosurg Psychiatry , vol.45 , pp. 308-312
    • Kanchandani, R.1    Howe, J.G.2
  • 22
    • 0025773861 scopus 로고
    • The origin of pain in optic neuritis. Determinants of pain in 101 eyes with optic neuritis
    • Lepore FE. The origin of pain in optic neuritis. Determinants of pain in 101 eyes with optic neuritis. Arch Neurol 1991; 48: 748-9.
    • (1991) Arch Neurol , vol.48 , pp. 748-749
    • Lepore, F.E.1
  • 23
    • 0042029406 scopus 로고    scopus 로고
    • Optic neuritis: Correlation of pain and magnetic resonance imaging
    • Fazzone HE, Lefton DR, Kupersmith MJ. Optic neuritis: correlation of pain and magnetic resonance imaging. Ophthalmology 2003; 110: 1646-9.
    • (2003) Ophthalmology , vol.110 , pp. 1646-1649
    • Fazzone, H.E.1    Lefton, D.R.2    Kupersmith, M.J.3
  • 24
    • 43149101314 scopus 로고    scopus 로고
    • Paroxysmal dystonia and pathological laughter as a first manifestation of multiple sclerosis
    • Aguirregomozcorta M, Ramió-Torrentà L, Gich J, Quiles A, Genís D. Paroxysmal dystonia and pathological laughter as a first manifestation of multiple sclerosis. Mult Scler 2008; 14: 262-5.
    • (2008) Mult Scler , vol.14 , pp. 262-265
    • Aguirregomozcorta, M.1    Ramió-Torrentà, L.2    Gich, J.3    Quiles, A.4    Genís, D.5
  • 25
    • 10344226168 scopus 로고    scopus 로고
    • A multimodal approach to managing the symptoms of multiple sclerosis
    • Crayton H, Heyman RA, Rossman HS. A multimodal approach to managing the symptoms of multiple sclerosis. Neurology 2004; 63: 12-8.
    • (2004) Neurology , vol.63 , pp. 12-18
    • Crayton, H.1    Heyman, R.A.2    Rossman, H.S.3
  • 26
  • 27
    • 0016784056 scopus 로고
    • Paroxysmal attacks in multiple sclerosis
    • Osterman PO, Westerberg CE. Paroxysmal attacks in multiple sclerosis. Brain 1975; 98: 189-202.
    • (1975) Brain , vol.98 , pp. 189-202
    • Osterman, P.O.1    Westerberg, C.E.2
  • 28
    • 0035956554 scopus 로고    scopus 로고
    • Paroxysmal dystonia (tonic spasm) in multiple sclerosis
    • Waubant E, Alizé P, Tourbah A, Agid Y. Paroxysmal dystonia (tonic spasm) in multiple sclerosis. Neurology 2001; 57: 2320-1.
    • (2001) Neurology , vol.57 , pp. 2320-2321
    • Waubant, E.1    Alizé, P.2    Tourbah, A.3    Agid, Y.4
  • 29
    • 4644322817 scopus 로고    scopus 로고
    • The prevalence of pain in multiple sclerosis: A multicenter cross-sectional study
    • Solaro C, Brichetto G, Amato MP, Cocco E, Colombo B, D'Aleo G, et al. The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study. Neurology 2004; 63: 919-21.
    • (2004) Neurology , vol.63 , pp. 919-921
    • Solaro, C.1    Brichetto, G.2    Amato, M.P.3    Cocco, E.4    Colombo, B.5    D'Aleo, G.6
  • 30
    • 33750334522 scopus 로고    scopus 로고
    • Efficacy of transcutaneous electrical nerve stimulation (TENS) for chronic low-back pain in a multiple sclerosis population: A randomized, placebo-controlled clinical trial
    • Warke K, Al-Smadi J, Baxter D, Walsh DM, Lowe-Strong AS. Efficacy of transcutaneous electrical nerve stimulation (TENS) for chronic low-back pain in a multiple sclerosis population: a randomized, placebo-controlled clinical trial. Clin J Pain 2006; 22: 812-9.
    • (2006) Clin J Pain , vol.22 , pp. 812-819
    • Warke, K.1    Al-Smadi, J.2    Baxter, D.3    Walsh, D.M.4    Lowe-Strong, A.S.5
  • 32
    • 0024511170 scopus 로고
    • Vascular headache: A presenting symptom of multiple sclerosis
    • Freedman MS, Gray TA. Vascular headache: a presenting symptom of multiple sclerosis. Can J Neurol Sci 1989; 16: 63-6.
    • (1989) Can J Neurol Sci , vol.16 , pp. 63-66
    • Freedman, M.S.1    Gray, T.A.2
  • 33
    • 0028446515 scopus 로고
    • The co-occurrence of multiple sclerosis and migraine headache: The serotoninergic link
    • Sandyk R, Awerbuch GI. The co-occurrence of multiple sclerosis and migraine headache: the serotoninergic link. Int J Neurosci 1994; 76: 249-57.
    • (1994) Int J Neurosci , vol.76 , pp. 249-257
    • Sandyk, R.1    Awerbuch, G.I.2
  • 34
    • 20444416296 scopus 로고    scopus 로고
    • The association of brainstem lesions with migraine-like headache: An imaging study of multiple sclerosis
    • Gee JR, Chang J, Dublin AB, Vijayan N. The association of brainstem lesions with migraine-like headache: an imaging study of multiple sclerosis. Headache 2005; 45: 670-7.
    • (2005) Headache , vol.45 , pp. 670-677
    • Gee, J.R.1    Chang, J.2    Dublin, A.B.3    Vijayan, N.4
  • 35
    • 0024991881 scopus 로고
    • Headaches and multiple sclerosis: A clinical study and review of the literature
    • Rolak LA, Brown S. Headaches and multiple sclerosis: a clinical study and review of the literature. J Neurol 1990; 237: 300-2.
    • (1990) J Neurol , vol.237 , pp. 300-302
    • Rolak, L.A.1    Brown, S.2
  • 36
    • 0032708140 scopus 로고    scopus 로고
    • Cluster headache-like pain in multiple sclerosis
    • Leandri M, Cruccu G, Gottlieb A. Cluster headache-like pain in multiple sclerosis. Cephalalgia 1999; 19: 732-4.
    • (1999) Cephalalgia , vol.19 , pp. 732-734
    • Leandri, M.1    Cruccu, G.2    Gottlieb, A.3
  • 37
    • 0037183484 scopus 로고    scopus 로고
    • Interferon beta but not glatiramer acetate therapy aggravates headaches in MS
    • Pöllmann W, Erasmus LP, Feneberg W, Then-Bergh F, Straube A. Interferon beta but not glatiramer acetate therapy aggravates headaches in MS. Neurology 2002; 59: 636-9.
    • (2002) Neurology , vol.59 , pp. 636-639
    • Pöllmann, W.1    Erasmus, L.P.2    Feneberg, W.3    Then-Bergh, F.4    Straube, A.5
  • 38
    • 0035954344 scopus 로고    scopus 로고
    • Acquired channelopathies in nerve injury and MS
    • Waxman SG. Acquired channelopathies in nerve injury and MS. Neurology 2001; 56: 1621-7.
    • (2001) Neurology , vol.56 , pp. 1621-1627
    • Waxman, S.G.1
  • 39
    • 33745107825 scopus 로고    scopus 로고
    • The immune system: A new look at pain
    • Zhang J, Huang Y. The immune system: a new look at pain. Chin Med J 2006; 119: 930-8.
    • (2006) Chin Med J , vol.119 , pp. 930-938
    • Zhang, J.1    Huang, Y.2
  • 40
    • 0027250195 scopus 로고
    • Anatomic-radiologic basis of Lhermitte's sign in multiple sclerosis
    • Gutrecht JA, Zamani AA, Salgado ED. Anatomic-radiologic basis of Lhermitte's sign in multiple sclerosis. Arch Neurol 1993; 50: 849-51.
    • (1993) Arch Neurol , vol.50 , pp. 849-851
    • Gutrecht, J.A.1    Zamani, A.A.2    Salgado, E.D.3
  • 41
    • 3843060543 scopus 로고    scopus 로고
    • Hyperalgesia in an animal model of multiple sclerosis
    • Aicher SA, Silverman MB, Winkler CW, Bebo BF. Hyperalgesia in an animal model of multiple sclerosis. Pain 2004; 110: 560-70.
    • (2004) Pain , vol.110 , pp. 560-570
    • Aicher, S.A.1    Silverman, M.B.2    Winkler, C.W.3    Bebo, B.F.4
  • 42
    • 0033656015 scopus 로고    scopus 로고
    • The pain of being sick: Implications of immune-to-brain communication for understanding pain
    • Watkins LR, Maier SF. The pain of being sick: implications of immune-to-brain communication for understanding pain. Ann Rev Psychol 2000; 51: 29-57.
    • (2000) Ann Rev Psychol , vol.51 , pp. 29-57
    • Watkins, L.R.1    Maier, S.F.2
  • 43
    • 0036845130 scopus 로고    scopus 로고
    • Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial
    • Nuki G, Bresnihan B, Bear MB, McCabe D. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002; 46: 2838-46.
    • (2002) Arthritis Rheum , vol.46 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3    McCabe, D.4
  • 44
    • 33744807730 scopus 로고    scopus 로고
    • Could chronic pain and spread of pain sensation be induced and maintained by glial activation?
    • Hansson E. Could chronic pain and spread of pain sensation be induced and maintained by glial activation? Acta Physiol 2006; 187: 321-7.
    • (2006) Acta Physiol , vol.187 , pp. 321-327
    • Hansson, E.1
  • 45
    • 0034917175 scopus 로고    scopus 로고
    • Trigeminal neuralgia due to multiple sclerosis: Ultrastructural findings in trigeminal rhizotomy specimens
    • Love S, Gradidge T, Coakham HB. Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminal rhizotomy specimens. Neuropathol Appl Neurobiol 2001; 27: 238-44.
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 238-244
    • Love, S.1    Gradidge, T.2    Coakham, H.B.3
  • 46
    • 0036244861 scopus 로고    scopus 로고
    • Disruption of thermal perception in a multiple sclerosis patient with central pain
    • Morin C, Bushnell MC, Luskin MB, Craig AD. Disruption of thermal perception in a multiple sclerosis patient with central pain. Clin J Pain 2002; 18: 191-5.
    • (2002) Clin J Pain , vol.18 , pp. 191-195
    • Morin, C.1    Bushnell, M.C.2    Luskin, M.B.3    Craig, A.D.4
  • 47
    • 0033556582 scopus 로고    scopus 로고
    • Positive symptoms in multiple sclerosis: Their treatment with sodium channel blockers, lidocaine and mexiletine
    • Sakurai M, Kanazawa I. Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine. J Neurol Sci 1999; 162: 162-8.
    • (1999) J Neurol Sci , vol.162 , pp. 162-168
    • Sakurai, M.1    Kanazawa, I.2
  • 48
    • 36049016785 scopus 로고    scopus 로고
    • Nuevos fármacos antiepilépticos y dolor neuropático. De la medicina molecular a la clínica.
    • Bermejo PE, Velasco R. Nuevos fármacos antiepilépticos y dolor neuropático. De la medicina molecular a la clínica. Med Clin (Barc) 2007; 129: 542-50.
    • (2007) Med Clin (Barc) , vol.129 , pp. 542-550
    • Bermejo, P.E.1    Velasco, R.2
  • 49
    • 0002814591 scopus 로고    scopus 로고
    • The treatment of neuropathic pain: Antidepressants and opioids
    • Watson CP. The treatment of neuropathic pain: antidepressants and opioids. Clin J Pain 2000; 16: 49-55.
    • (2000) Clin J Pain , vol.16 , pp. 49-55
    • Watson, C.P.1
  • 50
    • 36849070991 scopus 로고    scopus 로고
    • Oromucosal delta9-tetrahydrocannabinol/ cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, openlabel, 2-year extension trial
    • Rog DJ, Nurmikko TJ, Young CA. Oromucosal delta9-tetrahydrocannabinol/ cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, openlabel, 2-year extension trial. Clin Ther 2007; 29: 2068-79.
    • (2007) Clin Ther , vol.29 , pp. 2068-2079
    • Rog, D.J.1    Nurmikko, T.J.2    Young, C.A.3
  • 51
    • 35649019250 scopus 로고    scopus 로고
    • Cannabinoid control of neuroinflammation related to multiple sclerosis
    • Baker D, Jackson SJ, Pryce G. Cannabinoid control of neuroinflammation related to multiple sclerosis. Br J Pharmacol 2007; 152: 649-54.
    • (2007) Br J Pharmacol , vol.152 , pp. 649-654
    • Baker, D.1    Jackson, S.J.2    Pryce, G.3
  • 52
    • 38349156729 scopus 로고    scopus 로고
    • Cannabinoids and multiple sclerosis
    • Pertwee RG. Cannabinoids and multiple sclerosis. Mol Neurobiol 2007; 36: 45-59.
    • (2007) Mol Neurobiol , vol.36 , pp. 45-59
    • Pertwee, R.G.1
  • 53
    • 33750618230 scopus 로고    scopus 로고
    • Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain: A double-blind placebo-controlled cross-over trial
    • Wissel J, Haydn T, Müller J, Brenneis C, Berger T, Poewe W, et al. Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain: a double-blind placebo-controlled cross-over trial. J Neurol 2006; 253: 1337-41.
    • (2006) J Neurol , vol.253 , pp. 1337-1341
    • Wissel, J.1    Haydn, T.2    Müller, J.3    Brenneis, C.4    Berger, T.5    Poewe, W.6
  • 54
    • 61849162748 scopus 로고    scopus 로고
    • Implicación funcional del sistema cannabinoide endógeno en la homeostasis emocional.
    • Marco EM, Viveros M. Implicación funcional del sistema cannabinoide endógeno en la homeostasis emocional. Rev Neurol 2009; 48: 20-6.
    • (2009) Rev Neurol , vol.48 , pp. 20-26
    • Marco, E.M.1    Viveros, M.2
  • 55
    • 34247472645 scopus 로고    scopus 로고
    • Nuevos fármacos antiepilépticos en la profilaxis de la migraña.
    • Bermejo PE, Velasco R. Nuevos fármacos antiepilépticos en la profilaxis de la migraña. Med Clin (Barc) 2007; 128: 379-82.
    • (2007) Med Clin (Barc) , vol.128 , pp. 379-382
    • Bermejo, P.E.1    Velasco, R.2
  • 56
    • 69349096054 scopus 로고    scopus 로고
    • Papel de los neuromoduladores en el tratamiento preventivo de la migraña.
    • Pascual-Gómez J. Papel de los neuromoduladores en el tratamiento preventivo de la migraña. Rev Neurol 2009; 49: 25-32.
    • (2009) Rev Neurol , vol.49 , pp. 25-32
    • Pascual-Gómez, J.1
  • 57
    • 20844460450 scopus 로고    scopus 로고
    • Operative findings and outcomes of microvascular decompression for trigeminal neuralgia in 35 patients affected by multiple sclerosis
    • Broggi G, Ferroli P, Franzini A, Nazzi V, Farina L, La Mantia L, et al. Operative findings and outcomes of microvascular decompression for trigeminal neuralgia in 35 patients affected by multiple sclerosis. Neurosurgery 2004; 55: 830-8.
    • (2004) Neurosurgery , vol.55 , pp. 830-838
    • Broggi, G.1    Ferroli, P.2    Franzini, A.3    Nazzi, V.4    Farina, L.5    La Mantia, L.6
  • 58
    • 5444227104 scopus 로고    scopus 로고
    • What drives quality of life in multiple sclerosis?
    • Hemmett L, Holmes J, Barnes M, Russell N. What drives quality of life in multiple sclerosis? QJM 2004; 97: 671-6.
    • (2004) QJM , vol.97 , pp. 671-676
    • Hemmett, L.1    Holmes, J.2    Barnes, M.3    Russell, N.4
  • 59
    • 0034067174 scopus 로고    scopus 로고
    • Botulinum toxin (Dysport) treatment of hip adductor spasticity in multiple sclerosis: A prospective, randomised, double blind, placebo controlled, dose ranging study
    • Hyman N, Barnes M, Bhakta B, Cozens A, Bakheit M, Kreczy-Kleedorfer B, et al. Botulinum toxin (Dysport) treatment of hip adductor spasticity in multiple sclerosis: a prospective, randomised, double blind, placebo controlled, dose ranging study. J Neurol Neurosurg Psychiatry 2000; 68: 707-12.
    • (2000) J Neurol Neurosurg Psychiatry , vol.68 , pp. 707-712
    • Hyman, N.1    Barnes, M.2    Bhakta, B.3    Cozens, A.4    Bakheit, M.5    Kreczy-Kleedorfer, B.6
  • 61
    • 0028808063 scopus 로고
    • Clonidine in the treatment of spasticity in patients with multiple sclerosis
    • Khan OA, Olek MJ. Clonidine in the treatment of spasticity in patients with multiple sclerosis. J Neurol 1995; 242: 712-3.
    • (1995) J Neurol , vol.242 , pp. 712-713
    • Khan, O.A.1    Olek, M.J.2
  • 62
    • 20844448221 scopus 로고    scopus 로고
    • Overview of spasticity management in multiple sclerosis. Evidence-based management strategies for spasticity treatment in multiple sclerosis
    • Haselkorn JK, Balsdon-Richer C, Fry-Welch D, Herndon RM, Johnson B, Little JW, et al. Overview of spasticity management in multiple sclerosis. Evidence-based management strategies for spasticity treatment in multiple sclerosis. J Spinal Cord Med 2005; 28: 167-99.
    • (2005) J Spinal Cord Med , vol.28 , pp. 167-199
    • Haselkorn, J.K.1    Balsdon-Richer, C.2    Fry-Welch, D.3    Herndon, R.M.4    Johnson, B.5    Little, J.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.