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Volumn 45, Issue 2, 2010, Pages 379-384

Novel mechanism of rapamycin in GVHD: Increase in interstitial regulatory T cells

Author keywords

Graft versushost disease; Rapamycin; Regulatory T cells

Indexed keywords

RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

EID: 76749087402     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2009.140     Document Type: Article
Times cited : (13)

References (29)
  • 1
    • 0032102935 scopus 로고    scopus 로고
    • Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines
    • Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Vallera DA. Rapamycin Inhibits the Generation of Graft-Versus-Host Disease- and Graft-Versus-Leukemia- Causing T Cells by Interfering with the Production of Th1 or Th1 Cytotoxic Cytokines. J Immunol 1998; 160: 5355-5365.
    • (1998) J Immunol , vol.160 , pp. 5355-5365
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Vallera, D.A.4
  • 2
    • 24944570255 scopus 로고    scopus 로고
    • Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graftversus- Host disease
    • Couriel DR, Saliba R, Escalon MP, Hsu Y, Ghosh S, Ippoliti C et al. Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graftversus- host disease. Br J Haematol 2005; 130: 409-417.
    • (2005) Br J Haematol , vol.130 , pp. 409-417
    • Couriel, D.R.1    Saliba, R.2    Escalon, M.P.3    Hsu, Y.4    Ghosh, S.5    Ippoliti, C.6
  • 3
    • 4644262759 scopus 로고    scopus 로고
    • Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation
    • Antin JH, Cutler C. Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation. Bone Marrow Transplantation 2004; 34: 471-476.
    • (2004) Bone Marrow Transplantation , vol.34 , pp. 471-476
    • Antin, J.H.1    Cutler, C.2
  • 4
    • 0034571546 scopus 로고    scopus 로고
    • Graft-versus-host disease prevention by rapamycin: Cellular mechanisms
    • Chen BJ, Morris R, Chao NJ. Graft-Versus-Host Disease Prevention by Rapamycin: Cellular Mechanisms. Biol Blood Marrow Transplant 2000; 6: 529-536.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 529-536
    • Chen, B.J.1    Morris, R.2    Chao, N.J.3
  • 6
    • 0041941520 scopus 로고    scopus 로고
    • Sirolimus, tacrolimus, and low-Dose methotrexate for graftversus- Host disease prophylaxis in mismatched related donor or unrelated donor transplantation
    • Antin JH, Kim HT, Cutler C, Ho VT, Lee SJ, Miklos DB et al. Sirolimus, tacrolimus, and low-dose methotrexate for graftversus- host disease prophylaxis in mismatched related donor or unrelated donor transplantation. Blood 2003; 102: 1601-1605.
    • (2003) Blood , vol.102 , pp. 1601-1605
    • Antin, J.H.1    Kim, H.T.2    Cutler, C.3    Ho, V.T.4    Lee, S.J.5    Miklos, D.B.6
  • 7
    • 33947578933 scopus 로고    scopus 로고
    • Extended follow-Up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation
    • Cutler C, Li S, Ho VT, Koreth J, Alyea E, Soiffer RJ et al. Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation. Blood 2007; 109: 3108-3114.
    • (2007) Blood , vol.109 , pp. 3108-3114
    • Cutler, C.1    Li, S.2    Ho, V.T.3    Koreth, J.4    Alyea, E.5    Soiffer, R.J.6
  • 8
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells
    • Valmori D, Tosello V, Souleimanian NE, Godefroy E, Scotto L, Wang Y et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells. J Immunol 2006; 177: 944-949.
    • (2006) J Immunol , vol.177 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3    Godefroy, E.4    Scotto, L.5    Wang, Y.6
  • 9
    • 0033104824 scopus 로고    scopus 로고
    • Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
    • Powell JD, Lerner CG, Schwartz RH. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J Immunol 1999; 162: 2775-2784.
    • (1999) J Immunol , vol.162 , pp. 2775-2784
    • Powell, J.D.1    Lerner, C.G.2    Schwartz, R.H.3
  • 10
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-Specific foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178: 7018-7031.
    • (2007) J Immunol , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 11
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo M-G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005; 105: 4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.-G.3
  • 12
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of Both Healthy Subjects and Type 1 Diabetic Patients
    • Battaglia M, Stabilini A, Migliavacca B, Horejs-Hoeck J, Kaupper T, Roncarolo M-G. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of Both Healthy Subjects and Type 1 Diabetic Patients. J Immunol 2006; 177: 8338-8347.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3    Horejs-Hoeck, J.4    Kaupper, T.5    Roncarolo, M.-G.6
  • 13
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    • Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008; 111: 453-462.
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3    Kambham, N.4    Beilhack, A.5    Loh, J.6
  • 14
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
    • Strauss L, Whiteside TL, Knights A, Bergmann C, Knuth A, Zippelius A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J Immunol 2007; 178: 320-329.
    • (2007) J Immunol , vol.178 , pp. 320-329
    • Strauss, L.1    Whiteside, T.L.2    Knights, A.3    Bergmann, C.4    Knuth, A.5    Zippelius, A.6
  • 15
    • 14944346738 scopus 로고    scopus 로고
    • Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
    • Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 2005; 105: 2220-2226.
    • (2005) Blood , vol.105 , pp. 2220-2226
    • Ermann, J.1    Hoffmann, P.2    Edinger, M.3    Dutt, S.4    Blankenberg, F.G.5    Higgins, J.P.6
  • 16
    • 27644497249 scopus 로고    scopus 로고
    • Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    • Wysocki CA, Jiang Q, Panoskaltsis-Mortari A, Taylor PA, McKinnon KP, Su L et al. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood 2005; 107: 3300-3307.
    • (2005) Blood , vol.107 , pp. 3300-3307
    • Wysocki, C.A.1    Jiang, Q.2    Panoskaltsis-Mortari, A.3    Taylor, P.A.4    McKinnon, K.P.5    Su, L.6
  • 17
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation. J Exp Med 2002; 196: 389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 18
    • 32644448124 scopus 로고    scopus 로고
    • Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD
    • Rieger K, Loddenkemper C, Maul J, Fietz T, Wolff D, Terpe H et al. Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 2006; 107: 1717-1723.
    • (2006) Blood , vol.107 , pp. 1717-1723
    • Rieger, K.1    Loddenkemper, C.2    Maul, J.3    Fietz, T.4    Wolff, D.5    Terpe, H.6
  • 19
    • 34248653610 scopus 로고    scopus 로고
    • Role of naturally arising regulatory T cells in hematopoietic cell transplantation
    • Nguyen VH, Zeiser R, Negrin RS. Role of naturally arising regulatory T cells in hematopoietic cell transplantation. Biol Blood Marrow Transplant 2006; 12: 995-1009.
    • (2006) Biol Blood Marrow Transplant , vol.12 , pp. 995-1009
    • Nguyen, V.H.1    Zeiser, R.2    Negrin, R.S.3
  • 20
    • 33750905870 scopus 로고    scopus 로고
    • The initial phase of graft-Versus-Host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation
    • Schneider M, Munder M, Karakhanova S, Ho AD, Goerner M. The initial phase of graft-versus-host disease is associated with a decrease of CD4+CD25+ regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation. Clin Lab Hematol 2006; 28: 382-390.
    • (2006) Clin Lab Hematol , vol.28 , pp. 382-390
    • Schneider, M.1    Munder, M.2    Karakhanova, S.3    Ho, A.D.4    Goerner, M.5
  • 21
    • 34247862322 scopus 로고    scopus 로고
    • Expression of indoleamine 2, 3-Dioxygenase and the recruitment of Foxp3-Expressing regulatory T cells in the development and progression of uterine cervical cancer
    • Nakamura T, Shima T, Saeki A, Hidaka T, Nakashima A, Takikawa O et al. Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer. Cancer Sci 2007; 98: 874-881.
    • (2007) Cancer Sci , vol.98 , pp. 874-881
    • Nakamura, T.1    Shima, T.2    Saeki, A.3    Hidaka, T.4    Nakashima, A.5    Takikawa, O.6
  • 22
    • 33846493766 scopus 로고    scopus 로고
    • Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis
    • Bamias G, Okazawa A, Rivera-Nieves J, Arseneau KO, De La Rue SA, Pizarro TT et al. Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis. J Immunol 2007; 178: 1809-1818.
    • (2007) J Immunol , vol.178 , pp. 1809-1818
    • Bamias, G.1    Okazawa, A.2    Rivera-Nieves, J.3    Arseneau, K.O.4    De La Rue, S.A.5    Pizarro, T.T.6
  • 23
    • 34047130792 scopus 로고    scopus 로고
    • Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivoexpanded CD25-enriched products from healthy donors and patients with multiple sclerosis
    • Keever-Taylor CA, Browning M, Johnson B, Truitt R, Bredeson C, Behn B et al. Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivoexpanded CD25-enriched products from healthy donors and patients with multiple sclerosis. Cytotherapy 2007; 9: 144-157.
    • (2007) Cytotherapy , vol.9 , pp. 144-157
    • Keever-Taylor, C.A.1    Browning, M.2    Johnson, B.3    Truitt, R.4    Bredeson, C.5    Behn, B.6
  • 24
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • Zeiser R, Nguyen VH, Beilhack A, Buess M, Schulz S, Baker J et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3    Buess, M.4    Schulz, S.5    Baker, J.6
  • 25
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-Induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • Hackstein H, Taner T, Zahorchak AF, Morelli AE, Logar AJ, Gessner A et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003; 101: 4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3    Morelli, A.E.4    Logar, A.J.5    Gessner, A.6
  • 26
    • 0036682957 scopus 로고    scopus 로고
    • Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
    • Hackstein H, Taner T, Logar AJ, Thomson AW. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002; 100: 1084-1087.
    • (2002) Blood , vol.100 , pp. 1084-1087
    • Hackstein, H.1    Taner, T.2    Logar, A.J.3    Thomson, A.W.4
  • 27
    • 0037441902 scopus 로고    scopus 로고
    • Rapamycin specifically interferes withGMCSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    • Woltman AM, van der Kooij SW, Coffer PJ, Offringa R, Daha MR, van Kooten C. Rapamycin specifically interferes withGMCSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 2003; 101
    • (2003) Blood , vol.101 , pp. 1439-1445
    • Woltman, A.M.1    Van Der Kooij, S.W.2    Coffer, P.J.3    Offringa, R.4    Daha, M.R.5    An Kooten, C.6
  • 28
    • 33947203388 scopus 로고    scopus 로고
    • Vivo dynamics of regulatory T-Cell trafficking and survival predict effective strategies to control graft-Versus-Host disease following allogeneic transplantation
    • Nguyen VH, Zeiser R, daSilva DL, Chang DS, Beilhack A, Contag CH et al. In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 2007; 109: 2649-2656.
    • (2007) Blood , vol.109 , pp. 2649-2656
    • Nguyen, V.H.1    Zeiser, R.2    Dasilva, D.L.3    Chang, D.S.4    Beilhack, A.5    Contag, C.H.6
  • 29


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.