Degradation of paclitaxel and related compounds in aqueous solutions III: Degradation under acidic pH conditions and overall kinetics

Journal of Pharmaceutical Sciences

Volumn 99, Issue 3, 2010, Pages 1288-1298

  Tian, Jiaher ^a,b   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b FOREST RESEARCH INSTITUTE   (United States)

Author keywords

10 Deacetylbaccatin III; Acid catalysis; Baccatin III; Degradation; Hydrolysis; Oxetane ring cleavage; Paclitaxel; pH; Stability

Indexed keywords

10 DEACETYLBACCATIN; BACCATIN III; ESTER DERIVATIVE; HYDROXYL GROUP; OXETANE DERIVATIVE; PACLITAXEL; PROTON; TERPENOID; UNCLASSIFIED DRUG;

ACIDITY; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; DRUG DEGRADATION; DRUG STABILITY; EPIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; ULTRAVIOLET RADIATION;

EID: 76649144468     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21910     Document Type: Article

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