Update on cardiovascular implantable electronic device infections and their management: A scientific statement from the american heart association

Circulation

Volumn 121, Issue 3, 2010, Pages 458-477

  Baddour, Larry M ^a   Epstein, Andrew E ^a   Erickson, Christopher C ^a   Knight, Bradley P ^a   Levison, Matthew E ^a   Lockhart, Peter B ^a   Masoudi, Frederick A ^a   Okum, Eric J ^a   Wilson, Walter R ^a   Beerman, Lee B ^a   Bolger, Ann F ^a   Estes, N A Mark ^a   Gewitz, Michael ^a   Newburger, Jane W ^a   Schron, Eleanor B ^a   Taubert, Kathryn A ^a  

^a NONE

Author keywords

AHA Scientific Statements; Device, cardiovascular; Endocarditis; Implantable cardioverter defibrillator; Implantable electronic device; Infection; Pacemaker

Indexed keywords

ANTIINFECTIVE AGENT;

ALGORITHM; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; BIOFILM; CASE MANAGEMENT; COST OF ILLNESS; DEFIBRILLATION; DEFIBRILLATOR; DEVICE INFECTION; DEVICE REMOVAL; DISEASE CLASSIFICATION; HEART ARRHYTHMIA; HOST RESISTANCE; HUMAN; INFECTION PREVENTION; INFECTION RISK; MEDICAL ETHICS; MEDICAL SOCIETY; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; UNITED STATES;

AMERICAN HEART ASSOCIATION; CARDIOLOGY; DEFIBRILLATORS, IMPLANTABLE; ENDOCARDITIS; HUMANS; PACEMAKER, ARTIFICIAL; PROSTHESIS-RELATED INFECTIONS; UNITED STATES;

EID: 76649138577     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.192665     Document Type: Article

References (117)

1. Baddour LM, Bettmann MA, Bolger AF, Epstein AE, Ferrieri P, Gerber MA, Gewitz MH, Jacobs AK, Levison ME, Newburger JW, Pallasch TJ, Wilson WR, Baltimore RS, Falace DA, Shulman ST, Tani LY, Taubert KA. Nonvalvular cardiovascular device-related infections. Circulation. 2003;108:2015-2031.
2. Hayes DL, Furman S. Cardiac pacing: how it started, where we are, where we are going. Pacing Clin Electrophysiol. 2004;27:693-704. (Pubitemid 38648470)
3. Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA III, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Buller CE, Creager MA, Ettinger SM, Faxon DP, Halperin JL, Hiratzka LF, Hunt SA, Krumholz HM, Kushner FG, Lytle BW, Nishimura RA, Ornato JP, Page RL, Riegel B, Tarkington LG, Yancy CW; American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/ AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices); American Association for Thoracic Surgery; Society of Thoracic Surgeons. ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons [published correction appears in Circulation. 2009;120:e34-e35]. Circulation. 2008;117:e350-e408.
4. Zhan C, Baine WB, Sedrakyan A, Steiner C. Cardiac device implantation in the United States from 1997 through 2004: a population-based analysis. J Gen Intern Med. 2007;23(suppl 1):13-19.
5. Uslan DZ, Tleyjeh IM, Baddour LM, Friedman PA, Jenkins SM, St Sauver JL, Hayes DL. Temporal trends in permanent pacemaker implantation: a population-based study. Am Heart J. 2008;155:896-903.
6. Lin G, Meverden RA, Hodge DO, Uslan DZ, Hayes DL, Brady PA. Age and gender trends in implantable cardioverter defibrillator utilization: a population based study. J Interv Card Electrophysiol. 2008;22:65-70.
7. Mond HG, Irwin M, Morillo C, Ector H. The world survey of cardiac pacing and cardioverter defibrillators: calendar year 2001. Pacing Clin Electrophysiol. 2004;27:955-964.
8. Voigt A, Shalaby A, Saba S. Rising rates of cardiac rhythm management device infections in the United States: 1996 through 2003. J Am Coll Cardiol. 2006;48:590-591.
9. Schwartz IS, Pervez N. Bacterial endocarditis associated with a permanent transvenous cardiac pacemaker. JAMA. 1971;218:736-737.
10. Corman LC, Levison ME. Sustained bacteremia and transvenous cardiac pacemakers. JAMA. 1975;233:264-266.
11. Conklin EF, Giannelli S Jr, Nealon TF Jr. Four hundred consecutive patients with permanent transvenous pacemakers. J Thorac Cardiovasc Surg. 1975;69:1-7.
12. Bluhm G. Pacemaker infections: a clinical study with special reference to prophylactic use of some isoxazolyl penicillins. Acta Med Scand Suppl. 1985;699:1-62.
13. Arber N, Pras E, Copperman Y, Schapiro JM, Meiner V, Lossos IS, Militianu A, Hassin D, Pras E, Shai A, Moshkowitz M, Sidi Y. Pacemaker endocarditis: report of 44 cases and review of the literature. Medicine (Baltimore). 1994;73:299-305.
14. Mirowski M, Reid PR, Mower MM, Watkins L, Gott VL, Schauble JF, Langer A, Heilman MS, Kolenik SA, Fischell RE, Weisfeldt ML. Termination of malignant ventricular arrhythmias with an implanted automatic defibrillator in human beings. N Engl J Med. 1980;303: 322-324.
15. Mela T, McGovern BA, Garan H, Vlahakes GJ, Torchiana DF, Ruskin J, Galvin JM. Long-term infection rates associated with pectoral versus abdominal approach to cardioverter-defibrillator implants. Am J Cardiol. 2001;88:750-753.
16. Cabell CH, Heidenreich PA, Chu VH, Moore CM, Stryjewski ME, Corey GR, Fowler VG Jr. Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999. Am Heart J. 2004;147: 582-586.
17. Uslan DZ, Sohail MR, St Sauver JL, Friedman PA, Hayes DL, Stoner SM, Wilson WR, Steckelberg JM, Baddour LM. Permanent pacemaker and implantable cardioverter-defibrillator infection: a population-based study. Arch Intern Med. 2007;167:669-675.
18. Bloom H, Heeke B, Leon A, Mera F, Delurgio D, Beshai J, Langberg J. Renal insufficiency and the risk of infection from pacemaker or defi-brillator surgery. Pacing Clin Electrophysiol. 2006;29:142-145.
19. Lekkerkerker JC, van Nieuwkoop C, Trines SA, van der Bom JG, Bernards A, van de Velde ET, Bootsma M, Zeppenfeld K, Jukema JW, Borleffs JW, Schalij MJ, van Erven L. Risk factors and time delay associated with cardiac device infections: Leiden Device Registry. Heart. 2009;95:715-720.
20. Sohail MR, Uslan DZ, Khan AH, Friedman PA, Hayes DL, Wilson WR, Steckelberg JM, Stoner SM, Baddour LM. Risk factor analysis of permanent pacemaker infection. Clin Infect Dis. 2007;45:166-173.
21. Klug D, Balde M, Pavin D, Hidden-Lucet F, Clementy J, Sadoul N, Rey JL, Lande G, Lazarus A, Victor J, Barnay C, Grandbastien B, Kacet S; PEOPLE Study Group. Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study. Circulation. 2007;116:1349-1355.
22. Da Costa A, Kirkorian G, Cucherat M, Delahaye F, Chevalier P, Cerisier A, Isaaz K, Touboul P. Antibiotic prophylaxis for permanent pacemaker implantation: a meta-analysis. Circulation. 1998;97:1796-1801.
23. Trappe HJ, Pfitzner P, Klein H, Wenzlaff P. Infections after cardioverter-defibrillator implantation: observations in 335 patients over 10 years. Br Heart J. 1995;73:20-24.
24. Lai KK, Fontecchio SA. Infections associated with implantable cardio-verter defibrillators placed transvenously and via thoracotomies: epidemiology, infection control, and management. Clin Infect Dis. 1998;27: 265-269.
25. Al-Khatib SM, Lucas FL, Jollis JG, Malenka DJ, Wennberg DE. The relation between patients' outcomes and the volume of cardioverter-defibrillator implantation procedures performed by physicians treating Medicare beneficiaries [published correction appears in J Am Coll Cardiol. 2005;46:1964]. J Am Coll Cardiol. 2005;46:1536-1540.
26. Chamis AL, Peterson GE, Cabell CH, Corey GR, Sorrentino RA, Greenfield RA, Ryan T, Reller LB, Fowler VG Jr. Staphylococcus aureus bacteremia in patients with permanent pacemakers or implantable cardioverter-defibrillators. Circulation. 2001;104: 1029-1033.
27. Uslan DZ, Sohail MR, Friedman PA, Hayes DL, Wilson WR, Steck-elberg JM, Baddour LM. Frequency of permanent pacemaker or implantable cardioverter- defibrillator infection in patients with gram-negative bacteremia. Clin Infect Dis. 2006;43:731-736.
28. Johansen JB, Nielsen JC, Arnsbo P, Moller M, Pedersen AK, Mortensen PT. Higher incidence of pacemaker infection after replacement than after first implantation: experiences from 36,076 consecutive patients. Heart Rhythm. 2006;3(suppl 1):S102-S103.
29. Gould PA, Krahn AD; Canadian Heart Rhythm Society Working Group on Device Advisories. Complications associated with implantable cardioverter- defibrillator replacement in response to device advisories. JAMA. 2006;295:1907-1911.
30. Kapa S, Hyberger L, Rea RF, Hayes DL. Complication risk with pulse generator change: implications when reacting to a device advisory or recall. Pacing Clin Electrophysiol. 2007;30:730-733.
31. Darouiche R. Treatment of infections associated with surgical implants. N Engl J Med. 2004;350:1422-1429. (Pubitemid 38419996)
32. Chu VH, Crosslin DR, Friedman JY, Reed SD, Cabell CH, Griffiths RI, Masselink LE, Kaye KS, Corey GR, Reller LB, Stryjewski ME, Schulman KA, Fowler VG Jr. Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes. Am J Med. 2005; 118:1416.e19-1416.e24.
33. Camus C, Leport C, Raffi F, Michelet C, Cartier F, Vilde JL. Sustained bacteremia in patients with a permanent endocardial pacemaker: assessment of wire removal. Clin Infect Dis. 1993;17:46-55.
34. Klug D, Lacroix D, Savoye C, Goullard L, Grandmougin D, Hennequin JL, Kacet S, Lekieffre J. Systemic infection related to endocarditis on pacemaker leads: clinical presentation and management. Circulation. 1997;95:2098-2107.
35. Da Costa A, Lelièvre H, Kirkorian G, Célard M, Chevalier P, Vandenesch F, Etienne J, Touboul P. Role of the preaxillary flora in pacemaker infections: a prospective study. Circulation. 1998;97: 1791-1795.
36. Fu EY, Shepard RK. Permanent pacemaker infections. Card Electrophysiol Rev. 1999;3:39-41.
37. Chua JD, Wilkoff BL, Lee I, Juratli N, Longworth DL, Gordon SM. Diagnosis and management of infections involving implantable electro-physiologic cardiac devices. Ann Intern Med. 2000;133:604-608.
38. Sohail MR, Uslan DZ, Khan AH, Friedman PA, Hayes DL, Wilson WR, Steckelberg JM, Stoner S, Baddour LM. Management and outcome of permanent and implantable cardioverter-defibrillator infections. J Am Coll Cardiol. 2007;49:1851-1859.
39. Villamil Cajoto I, Rodríguez Framil M, Van den Eynde Collado A, José Villacián Vicedo M, Canedo Romero C. Permanent transvenous pacemaker infections: an analysis of 59 cases. Eur J Intern Med. 2007; 18:484-488.
40. del Rio A, Anguera I, Miró JM, Mont L, Fowler VG Jr, Azqueta M, Mestres CA; Hospital Clinic Endocarditis Study Group. Surgical treatment of pacemaker and defibrillator lead endocarditis: the impact of electrode lead extraction on outcome. Chest. 2003;124:1451-1459.
41. Kloos WE, Bannermann TL. Update on the clinical significance of coagulase-negative staphylococci. Clin Microbiol Rev. 1994;7:117-140.
42. Cacoub P, Leprince P, Nataf P, Hausfater P, Dorent R, Wechsler B, Bors V, Pavie A, Piette JC, Gandjbakhch I. Pacemaker infective endocarditis. Am J Cardiol. 1998;82:480-484.
43. Chacko ST, Chandy ST, Abraham OC, Swaminathan S, Varghese GM, Priscilla R, Mathai. Pacemaker endocarditis caused by Pseudomonas aeruginosa treated successfully. JAPI. 2003;51:1021-1022.
44. Kouvousis NM, Lazaros GA, Christoforatou EG, Deftereos SG, Milona-Petropoulou DE, Lelekis MG, Zacharoulis AA. Acremonium species pacemaker site infection. Hellenic J Cardiol. 2003;44:83-87.
45. Amin M, Gross J, Andrews C, Furman S. Pacemaker infection with Mycobacterium avium complex. Pacing Clin Electrophysiol. 1991;14: 152-154.
46. Giannella M, Valerio M, Franco J, Marin M, Bouza E, Muñoz P. Pacemaker infection due to Mycobacterium fortuitum: the role of universal 16S rRNA gene PCR and sequencing. Diagn Microbiol Infect Dis. 2007;57:337-339.
47. Kernodle DS, Barg NL, Kaiser AB. Low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphy-lococci and emergence of the organisms during surgical antimicrobial prophylaxis. Antimicrob Agents Chemother. 1988;32:202-208.
48. Archer GL, Climo MW. Antimicrobial susceptibility of coagulase-negative staphylococci. Antimicrob Agents Chemother. 1994;38: 2231-2237.
49. Abraham J, Mansour C, Veledar E, Khan B, Lerakis S. Staphylococcus aureus bacteremia and endocarditis: the Grady Memorial Hospital experience with methicillin-sensitive S aureus and methicillin-resistant S aureus bacteremia. Am Heart J. 2004;147:536-539.
50. Vuong C, Otto M. Staphylococcus epidermidis infections. Microbes Infect. 2002;4:481-489.
51. Darouiche RO. Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;33:1567-1572.
52. Phaller MA, Herwaldt LA. Laboratory, clinical, and epidemiological aspects of coagulase-negative staphylococci. Clin Microbiol Rev. 1988; 1:281-299.
53. Veenstra GJ, Cremers FF, van Dijk H, Fleer A. Ultrastructural organization and regulation of a biomaterial adhesion of Staphylococcus epi-dermidis. J Bacteriol. 1996;178:537-541.
54. Kojima Y, Tojo M, Goldmann DA, Tosteson TD, Pier GB. Antibody to the capsular polysaccharide/adhesin protects rabbits against catheter-related bacteremia due to coagulase-negative staphylococci. J Infect Dis. 1990;162:435-441.
55. Takeda S, Pier GB, Kojima Y, Tojo M, Muller E, Tosteson T, Goldmann DA. Protection against endocarditis due to Staphylococcus epidermidis by immunization with capsular polysaccharide/adhesin. Circulation. 1991;84:2539-2546.
56. Wilkinson BJ. Biology. In: The Staphylococci in Human Disease. Crossley KB, Archer GL, eds. New York, NY: Churchill Livingston; 1997.
57. Francois P, Vaudaux P, Lew PD. Role of plasma and extracellular matrix proteins in the pathophysiology of foreign body infections. Ann Vasc Surg. 1998;12:34-40.
58. Vaudaux P, François P, Proctor RA, McDevitt D, Foster TJ, Albrecht RM, Lew DP, Wabers H, Cooper SL. Use of adhesion-defective mutants of Staphylococcus aureus to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts [published correction appears in Infect Immun. 1995;63:3239]. Infect Immun. 1995;63:585-590.
59. Heilmann C, Schweitzer O, Gerke C, Vanittanakom N, Mack D, Götz F. Molecular basis of intercellular adhesion in the biofilm-forming Staph-ylococcus epidermidis. Mol Microbiol. 1996;20:1083-1091.
60. Bayston R, Penny SR. Excessive production of mucoid substance in staphylococcus SIIA: a possible factor in colonisation of Holter shunts. Dev Med Child Neurol Suppl. 1972;27:25-28.
61. Baddour LM, Barker LP, Christensen GS, Parisi JT, Simspon WA. Phenotypic variation of Staphylococcus epidermidis in infection of transvenous endocardial pacemaker electrodes. J Clin Microbiol. 1990; 28:676-679.
62. Seifert H, Wisplinghoff H, Schnabel P, von Eiff C. Small colony variants of Staphylococcus aureus and pacemaker-related infection. Emerg Infect Dis. 2003;9:1316-1318.
63. Seifert H, Oltmanns D, Becker K, Wisplinghoff H, von Eiff C. Staphylococcus lugdunensis pacemaker-related infection. Emerg Infect Dis. 2005;11:1283-1286.
64. Boelens JJ, Dankert J, Murk JL, Weening JJ, van der Poll T, Dingemans KP, Koole L, Laman JD, Zaat SA. Biomaterial-associated persistence of Staphylococcus epidermidis in pericatheter macrophages. J Infect Dis. 2000;181:1337-1349.
65. von Eiff C, Heilmann C, Proctor RA, Woltz C, Peters G, Götz F. A site-directed Staphylococcus aureus hemB mutant is a small colony variant which persists intracellularly. J Bacteriol. 1997;179:4706-4712.
66. Balwit JM, van Langevelde P, Vann JM, Proctor RA. Gentamicin-re-sistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells. J Infect Dis. 1994;170:1033-1037.
67. Fowler VG Jr, Li J, Corey GR, Boley J, Marr KA, Gopal AK, Kong LK, Gottlieb G, Donovan CL, Sexton DJ, Ryan T. Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Cardiol. 1997;30:1072-1078.
68. Lo R, D'Anca M, Cohen T, Kerwin T. Incidence and prognosis of pacemaker lead-associated masses: a study of 1,569 transesophageal echocardiograms. J Invasive Cardiol. 2006;18:599-601.
69. Dy Chua J, Abdul-Karim A, Mawhorter S, Procop GW, Tchou P, Niebauer M, Saliba W, Schweikert R, Wilkoff BL. The role of swab and tissue culture in the diagnosis of implantable cardiac device infection. Pacing Clin Electrophysiol. 2005;28:1276-1281.
70. Love CJ, Wilkoff BL, Byrd CL, Belott PH, Brinker JA, Fearnot NE, Friedman RA, Furman S, Goode LB, Hayes DL, Kawanishi DT, Par-sonnet V, Reiser C, Van Zandt HJ. Recommendations for extraction of chronically implanted transvenous pacing and defibrillator leads: indications, facilities, training. Pacing Clin Electrophysiol. 2000;23: 544-551.
71. Gaynor SL, Zierer A, Lawton JS, Gleva MJ, Damiano RJ, Moon MR. Laser assistance for extraction of chronically implanted endocardial leads: infectious versus noninfectious indications. Pacing Clin Electrophysiol. 2006;29:1352-1358.
72. Field ME, Jones SO, Epstein LM. How to select patients for lead extraction. Heart Rhythm. 2007;4:978-985.
73. Jones SO IV, Eckart RE, Albert CM, Epstein LM. Large, single-center, single-operator experience with transvenous lead extraction: outcomes and changing indications. Heart Rhythm. 2008;5:520-525.
74. Smith MC, Love CJ. Extraction of transvenous pacing and ICD leads. Pacing Clin Electrophysiol. 2008;31:736-752.
75. Uslan DZ, Dowsley TF, Sohail MR, Hayes DL, Friedman PA, Wilson WR, Steckelberg JM, Baddour LM. Cardiovascular implantable electronic device infection in patients with Staphylcoccus aureus bacteremia. Pacing Clin Electrophysiol. September 30, 2009. doi: 10.1111/j.1540-8159.2009.02565.x. Accessed October 21, 2009.
76. Sopeña B, Crespo M, Beiras X, del Campo EG, Rivera A, Gimena B, Maure B, Martínez-Vásquez C. Individualized management of bacteraemia in patients with a permanent endocardial pacemaker. Clin Microbiol Infect. Published online before print May 16, 2009. doi: 10.1111/j.1469-0691. 2009.02787.x. Available at: http://www3. interscience.wiley.com/journal/ 122387704/abstract?CRETRY= 1& SRETRY = 0. Accessed October 21, 2009.
77. Braun MU, Rauwolf T, Bock M, Kappert U, Boscheri A, Schnabel A, Strasser RH. Percutaneous lead implantation connected to an external device in stimulation-dependent patients with systemic infection: a prospective and controlled study. Pacing Clin Electrophysiol. 2006;29: 875-879.
78. Mansour KA, Kauten JR, Hatcher CR Jr. Management of the infected pacemaker: explantation, sterilization, and reimplantation. Ann Thorac Surg. 1985;40:617-619.
79. Nandyala R, Parsonnet V. One stage side-to-side replacement of infected pulse generators and leads. Pacing Clin Electrophysiol. 2006; 29:393-396.
80. Panja M, Sarkar CN, Kumar S, Kar AK, Mitra S, Sinha DP, Chatterjee A, Roy S, Sarkar NC, Majumder B. Reuse of pacemaker. Indian Heart J. 1996;48:677-680.
81. Baddour LM; Infectious Diseases Society of America's Emerging Infections Network. Long-term suppressive antimicrobial therapy for intravascular device-related infections. Am J Med Sci. 2001;322: 209-212.
82. Kay GN, Brinker JA, Kawanishi DT, Love CJ, Lloyd MA, Reeves RC, Pioger G, Fee J, Overland MK, Ensign LG, Grunkemeier GL. Risks of spontaneous injury and extraction of an active fixation pacemaker lead: report of the Accufix Multicenter Clinical Study and Worldwide Registry. Circulation. 1999;100:2344-2352.
83. Bracke F, Meijer A, Van Gelder B. Extraction of pacemaker and implantable cardioverter defibrillator leads: patient and lead characteristics in relation to the requirement of extraction tools. Pacing Clin Electrophysiol. 2002;23:1037-1040.
84. O'Nunain S, Perez I, Roelke M, Osswald S, McGovern BA, Brooks DR, Torchiana DF, Vlahakes GJ, Ruskin J, Garan H. The treatment of patients with infected cardioverter-defibrillator systems. J Thorac Car-diovasc Surg. 1997;113:121-129.
85. Molina JE. Undertreatment and overtreatment of patients with infected antiarrhythmic implantable devices. Ann Thorac Surg. 1997;63: 504-509.
86. Rundstrom H, Kennergren C, Andersson R, Alestig K, Hogevik H. Pacemaker endocarditis during 18 years in Goteborg. Scand J Infect Dis. 2004;36:674-679.
87. Sohail MR, Uslan DZ, Khan AH, Friedman PA, Hayes DL, Wilson WR, Steckelberg JM, Jenkins SM, Baddour LM. Infective endocarditis complicating permanent pacemaker and implantable cardioverter-defibrillator infection. Mayo Clin Proceed. 2008;83:46-53.
88. Baman TS, Gupta SK, Valle JA, Yamada E. Risk factors for mortality in patients with cardiac device-related infection. Circ Arrhythm Elec-trophysiol. 2009;2:129-134.
89. de Oliveira JC, Martinelli M, D'Orio Nishioka SA, Varejão T, Uipe D, Andrade Pedrosa AA, Costa R, Danik SB. Efficacy of antibiotic prophylaxis before the implantation of pacemakers and cardioverter-defibrillators: results of a large, prospective, randomized, double-blinded, placebo-controlled trial. Circ Arrhythm Electrophysiol. 2009; 2:29-34.
90. Cohen MI, Bush DM, Gaynor JW, Vetter VL, Tanel RE, Rhodes LA. Pediatric pacemaker infections: twenty years of experience. J Thorac Cardiovasc Surg. 2002;124:821-827.
91. Robinson M, Healey JS, Eikelboom J, Schulman S, Morillo CA, Nair GM, Baranchuk A, Ribas S, Evans G, Connolly SJ, Turpie AG. Postoperative low-molecular-weight heparin bridging is associated with an increase in wound hematoma following surgery for pacemakers and implantable defibrillators. Pacing Clin Electrophysiol. 2009;32: 378-382.
92. Deuling JH, Smit MD, Maass AH, Van den Heuvel AF, Nieuwland W, Zijlstra F, Van Gelder IC. The value and limitations of a wound inspection clinic after cardiac device implantation. Eur J Cardiovasc Nurs. 2009;8:288-292.
93. Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with toothbrushing and dental extraction. Circulation. 2008;117:3118-3125.
94. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, Bolger A, Cabell CH, Takahashi M, Baltimore RS, Newburger JW, Strom BL, Tani LY, Gerber M, Bonow RO, Pallasch T, Shulman ST, Rowley AH, Burns JC, Ferrieri P, Gardner T, Goff D, Durack DT. Prevention of infective endocarditis: guideline from the American Heart Association: a guideline from the American Heart Association's Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council of Clinical Cardiology, Council on Cardiovascular Surgery, and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group [published correction appears in Circulation. 2007;116: e376-e377]. Circulation. 2007;116:1736-1754.
95. Tong DC, Rothwell BR. Antibiotic prophylaxis in dentistry: a review and practice recommendations. J Am Dent Assoc. 2000;131:366-374.
96. Pallasch TJ. Antibiotic prophylaxis. Endod Topics. 2003;4:46-59.
97. Lockhart PB, Brennan MT, Fox PC, Norton HJ, Jernigan DB, Strausbaugh LJ. Decision-making on the use of antimicrobial prophylaxis for dental procedures: a survey of infectious disease consultants and review. Clin Infect Dis. 2002;34:1621-1626.
98. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43: 5721-5732.
99. Lockhart PB, Loven B, Brennan MT, Fox PC. The evidence base for the efficacy of antibiotic prophylaxis in dental practice. J Am Dent Assoc. 2007;138:458-474.
100. Bahrani-Mougeot FK, Paster BJ, Coleman S, Ashar J, Barbuto S, Lockhart PB. Diverse and novel oral bacterial species in blood following dental procedures. J Clin Microbiol. 2008;46:2129-2132.
101. Rosen MR, Brink PR, Cohen IS, Danilo P Jr, Robinson RB, Rosen AB, Szabolcs MJ. Regenerative therapies in electrophysiology and pacing. J Interv Card Electrophysiol. 2008;22:87-98.
102. Gepstein L. Experimental molecular and stem cell therapies in cardiac electrophysiology. Ann NY Acad Sci. 2008;1123:224-231.
103. Kizana E. Therapeutic prospects of cardiac gene transfer. Heart Lung Circ. 2007;16:180-184.
104. Rissanen TT, Ylä-Herttuala S. Current status of cardiovascular gene therapy. Mol Ther. 2007;15:1233-1247.
105. Klug K, Vaksman G, Jarwé M, Wallet F, Francart C, Kacet S, Rey C. Pacemaker lead infection in young patients. Pacing Clin Electrophysiol. 2003;26:1489-1493.
106. Kammeraad JAE, Rosenthal E, Bostock J, Rogers J, Sreeram N. Endocardial pacemaker implantation in infants weighing 10 kilograms. Pacing Clin Electrophysiol. 2004;27:1466-1474
107. Costa R, Filho MM, Tamaki WT, Crevelari ES, Nishioka SD, Moreira LF, Oliveira SA. Transfemoral pediatric permanent pacing: long-term results. Pacing Clin Electrophysiol. 2003;26(part II):487-491.
108. Lau YR, Gillette PC, Buckles DS, Zeigler VL. Actuarial survival of transvenous pacing leads in a pediatric population. Pacing Clin Electrophysiol. 1993;16(part I):1363-1367.
109. Walsh CA, McAlister HF, Andrews CA, Steeg CN, Eisenberg R, Furman S. Pacemaker implantation in children: a 21-year experience. Pacing Clin Electrophysiol. 1988;11(part II):1940-1944.
110. Till JA, Jones S, Rowland E, Shinebourne EA, Ward DE. Endocardial pacing in infants and children 15 kg or less in weight: medium-term follow-up. Pacing Clin Electrophysiol. 1990;13(part 1):1385-1392.
111. Noiseux N, Khairy P, Fournier A, Vobecky SJ. Thirty years of experience with epicardial pacing in children. Cardiol Young. 2004;14: 512-519.
112. Dodge-Khatami A, Kadner A, Dave H, Rahn M, Prêtre R, Bauersfeld U. Left heart atrial and ventricular epicardial pacing through a left lateral thoracotomy in children: a safe approach with excellent functional and cosmetic results. Eur J Cardiothorac Surg. 2005;28:541-545.
113. Villain E, Martelli H, Bonnet D, Iserin L, Butera G, Kachaner J. Characteristics and results of epicardial pacing in neonates and infants. Pacing Clin Electrophysiol. 2000;23:2052-2056.
114. Silvetti MS, Drago F, Grutter G, DeSantis A, DiCiommo V, Ravà L. Twenty years of paediatric cardiac pacing: 515 pacemakers and 480 leads implanted in 292 patients. Europace. 2006;8:530-536.
115. Silka MJ, Kron J, Dunnigan A, Dick M II. Sudden cardiac death and the use of implantable cardioverter-defibrillators in pediatric patients: the Pediatric Electrophysiology Society. Circulation. 1993; 87:800-807.
116. Berul CI, Van Hare GF, Kertesz NJ, Dubin AM, Cecchin F, Collins KK, Cannon BC, Alexander ME, Triedman JK, Walsh EP, Friedman RA. Results of a multicenter retrospective implantable cardioverter-defibrillator registry of pediatric and congenital heart disease patients. J Am Coll Cardiol. 2008;51:1685-1691.
117. Link MS, Hill SL, Cliff DL, Swygman CA, Foote CB, Homoud MK, Wang PJ, Estes NAM III, Berul CI. Comparison of frequency of complications of implantable cardioverter-defibrillators in children versus adults. Am J Cardiol. 1999;83:263-266.