PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: Prognostic significance

Oncology Reports

Volumn 23, Issue 2, 2010, Pages 537-544

  Escudero Esparza, Astrid ^a   Martin, Tracey A ^a   Douglas Jones, Anthony ^a   Mansel, Robert E ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Breast cancer; Immunohistochemistry; Neuropilin 1 receptor; Placenta growth factor; Prognosis; Real time quantitative polymerase chain reaction; Vascular endothelial growth factor

Indexed keywords

ESTROGEN RECEPTOR; NEUROPILIN; PLACENTAL GROWTH FACTOR; PLACENTAL GROWTH FACTOR 1; PLACENTAL GROWTH FACTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

BREAST NEOPLASMS; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAMMARY GLANDS, HUMAN; NEUROPILINS; PREGNANCY PROTEINS; PROGNOSIS; PROTEIN ISOFORMS; RECEPTORS, ESTROGEN; SURVIVAL ANALYSIS;

EID: 76649126441     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000667     Document Type: Article

References (19)

1. Zetter BR: Angiogenesis and tumor metastasis. Annu Rev Med 49: 407-424, 1998.
2. Wirzenius M, Tammela T, Uutela M, et al: Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med 204: 1431-1440, 2007.
3. Marcellini M, De Luca N, Riccioni T, et al: Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor. Am J Pathol 169: 643-654, 2006.
4. Yang W, Ahn H, Hinrichs M, Torry RJ and Torry DS: Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells. J Reprod Immunol 60: 53-60, 2003.
5. Roy H, Bhardwaj S and Yla-Herttuala S: Biology of vascular endothelial growth factors. FEBS Lett 580: 2879-2887, 2006.
6. Sawano A, Takahashi T, Yamaguchi S, Aonuma M and Shibuya M: Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth Differ 7: 213-221, 1996.
7. Migdal M, Huppertz B, Tessler S, et al: Neuropilin-1 is a placenta growth factor-2 receptor. J Biol Chem 273: 22272-22278, 1998.
8. Zhang L, Chen J, Ke Y, Mansel RE and Jiang WG: Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance. World J Surg Oncol 3: 68, 2005.
9. Taylor AP and Goldenberg DM: Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts. Mol Cancer Ther 6: 524-531, 2007.
10. Staton CA, Kumar I, Reed MW and Brown NJ: Neuropilins in physiological and pathological angiogenesis. J Pathol 212: 237-248, 2007.
11. Parr C, Watkins G, Boulton M, Cai J and Jiang WG: Placenta growth factor is over-expressed and has prognostic value in human breast cancer. Eur J Cancer 41: 2819-2827, 2005.
12. Jiang WG, Douglas-Jones A and Mansel RE: Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes. Int J Cancer 106: 752-757, 2003.
13. Jiang WG, Watkins G, Douglas-Jones A, Mokbel K, Mansel RE and Fodstad O: Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status. Int J Cancer 117: 730-737, 2005.
14. Martin TA, Parr C, Davies G, et al: Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis 24: 1317-1323, 2003.
15. Martin TA, Watkins G, Mansel RE and Jiang WG: Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer. Eur J Cancer 40: 2717-2725, 2004.
16. Parr C, Gan CH, Watkins G and Jiang WG: Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients. Angiogenesis 9: 73-81, 2006.
17. Suen D and Chow LW: Prognostic contribution of the HER-2 oncogene overexpression to the Nottingham Prognostic Index in breast cancer. Biomed Pharmacother 60: 293-297, 2006.
18. Ghosh S, Sullivan CA, Zerkowski MP, et al: High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer. Hum Pathol 39: 1835-1843, 2008.
19. Barr MP, Byrne AM, Duffy AM, et al: A peptide corresponding to the neuropilin-1-binding site on VEGF(165) induces apoptosis of neuropilin-1-expressing breast tumour cells. Br J Cancer 92: 328-333, 2005.