Expression and prognostic value of Id protein family in human breast carcinoma

Oncology Reports

Volumn 23, Issue 2, 2010, Pages 321-328

  Yang, Hai Yan ^a   Liu, Hao Ling ^a   Ke, Jia ^a   Wu, He ^a   Zhu, Hong ^a   Liu, Jia Ren ^b   Liu, Lian Xin ^a   Jiang, Hong Chi ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Breast carcinoma; Id proteins; Immunohistochemistry; Prognosis

Indexed keywords

INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; INHIBITOR OF DIFFERENTIATION 4; INHIBITOR OF DIFFERENTIATION PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEINS; MAMMARY GLANDS, HUMAN; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 76649115349     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000639     Document Type: Article

References (22)

1. Greenlee RT, Murray T, Bolden S and Wingo PA: Cancer statistics. CA Cancer J Clin 50: 7-33, 2000.
2. Perk J, Iavarone A and Benezra R: Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 5: 603-614, 2005.
3. Zebedee Z and Hara E: Id proteins in cell cycle control and cellular senescence. Oncogene 20: 8317-8325, 2001.
4. Wilson JW, Deed RW, Inoue T, Balzi M, Becciolini A, Faraoni P, Potten CS and Norton JD: Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res 61: 8803-8810, 2001.
5. Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ and Hoon DS: Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. Clin Cancer Res 10: 7475-7483, 2004.
6. Schindl M, Oberhuber G, Obermair A, Schoppmann SF, Karner B and Birner P: Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer. Cancer Res 61: 5703-5736, 2001.
7. Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, Marubashi S, Miyamoto A, Umeshita K, Dono K, Nakamori S, Wakasa K, Sakon M and Monden M: Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol 26: 319-327, 2005.
8. Jang TJ, Jung KH and Choi EA: Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer. Int J Cancer 118: 1356-1363, 2006.
9. Chan AS, Tsui WY, Chen X, Chu KM, Chan TL, Chan AS, Li R, So S, Yuen ST and Leung SY: Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. Oncogene 22: 6946-6953, 2003.
10. Tsuchiya T, Okaji Y, Tsuno NH, Sakurai D, Tsuchiya N, Kawai K, Yazawa K, Asakage M, Yamada J, Yoneyama S, Kitayama J, Osada T, Watanabe T, Tokunaga K, Takahashi K and Nagawa H: Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. Cancer Sci 96: 784-790, 2005.
11. Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J and Desprez PY: A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 60: 1332-1340, 2000.
12. Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL and Desprez PY: Role of Id-2 in the maintenance of a differentiated and non-invasive phenotype in breast cancer cells. Cancer Res 63: 7098-7105, 2003.
13. Roldán G, Delgado L and Musé IM: Tumoral expression of BRCA1, estrogen receptor alpha and ID4 protein in patients with sporadic breast cancer. Cancer Biol Ther 5: 505-510, 2006.
14. Umetani N, Mori T and Koyanagi K: Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer. Oncogene 24: 4721-4727, 2005.
15. Fong S, Itahana Y and Sumida T: Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci USA 100: 13543-13548, 2003.
16. Kim HJ, Chung H and Yoo YG: Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha. Mol Cancer Res 5: 321-329, 2007.
17. Maruyama H, Kleeff J and Wildi S: Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am J Pathol 155: 815-822, 1999.
18. Arnold JM, Mok SC and Purdie D: Decreased expression of the Id3 gene at 1p36.1 in ovarian adenocarcinomas. Br J Cancer 84: 352-359, 2001.
19. Lyden D, Young AZ and Zagzag D: Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401: 670-677, 1999.
20. Shan L, Yu M and Qiu C: Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. Am J Pathol 163: 2495-2502, 2003.
21. Welcsh PL, Lee MK and Gonzalez-Hernandez RM: BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci USA 99: 7560-7565, 2002.
22. Beger C, Pierce LN and Kruger M: Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-librarybased inverse genomics approach. Proc Natl Acad Sci USA 98: 130-135, 2001.