Determination of paclitaxel and its analogues in the needles of Taxus species by using negative pressure cavitation extraction followed by HPLC-MS-MS

Journal of Separation Science

Volumn 32, Issue 22, 2009, Pages 3958-3966

  Li, Shuangming ^a   Fu, Yujie ^a   Zu, Yuangang ^a   Zu, Baishi ^a   Wang, Ying ^a   Efferth, Thomas ^b  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Determination; Negative pressure cavitation (NPC); Paclitaxel; Separation; Taxoids

Indexed keywords

CELLULAR DAMAGE; CONVENTIONAL EXTRACTION; DETERMINATION; EXTRACTION CONDITIONS; EXTRACTION MECHANISMS; EXTRACTION SOLVENTS; EXTRACTION TIME; FACILE METHOD; HERBAL PLANTS; HIGH TEMPERATURE; HPLC-MS-MS; LOW TEMPERATURES; MORPHOLOGICAL CHANGES; NEGATIVE PRESSURES; PACLITAXEL; SEM IMAGE; TAXOIDS; TAXUS CHINENSIS; TAXUS CUSPIDATA; THERMAL DECOMPOSITIONS; VACUUM DEGREE;

CAVITATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; NEEDLES; ORGANIC POLYMERS; PLANTS (BOTANY); PYROLYSIS; SEPARATION; VACUUM;

SOLVENT EXTRACTION;

10 DEACETYL 7 XYLOSYLPACLITAXEL; 10 DEACETYLPACLITAXEL; ALCOHOL; CEPHALOMANNINE; PACLITAXEL; PACLITAXEL DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL STRUCTURE; CONIFER NEEDLE; CONTROLLED STUDY; DECOMPOSITION; DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; ECONOMIC ASPECT; EXTRACTION; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; LIQUID; LOW TEMPERATURE; MASS SPECTROMETRY; MORPHOLOGY; NEGATIVE PRESSURE CAVITATION EXTRACTION; PRESSURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SOLID; TAXUS; TAXUS CHINENSIS; TAXUS CUSPIDATA; TIME; VACUUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICROSCOPY, ELECTRON, SCANNING; PACLITAXEL; PRESSURE; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY; TAXUS;

TAXUS; TAXUS CUSPIDATA; TAXUS WALLICHIANA VAR. CHINENSIS;

EID: 76649109608     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900402     Document Type: Article

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